| 1 | Sat 28 Aug 2021 | 201-0 v PEC ZwolleWillem II 1-0 PEC Zwolle | Dutch Eredivisie |
| 2 | Sat 18 Sep 2021 | 202-1 v FC GroningenWillem II 2-1 FC Groningen | Dutch Eredivisie |
| 3 | Tue 21 Sep 2021 | 202-1 v RKC WaalwijkRKC Waalwijk 1-2 Willem II | Dutch Eredivisie |
| 4 | Fri 22 Oct 2021 | 201-1 v Fortuna SittardWillem II 1-1 Fortuna Sittard | Dutch Eredivisie |
| 5 | Sun 31 Oct 2021 | 201-5 v FC UtrechtFC Utrecht 5-1 Willem II | Dutch Eredivisie |
| 6 | Sat 6 Nov 2021 | 200-3 v Sparta RotterdamWillem II 0-3 Sparta Rotterdam | Dutch Eredivisie |
| 7 | Sun 21 Nov 2021 | 201-2 v sc Heerenveensc Heerenveen 2-1 Willem II | Dutch Eredivisie |
| 8 | Sat 27 Nov 2021 | 200-1 v Go Ahead EaglesWillem II 0-1 Go Ahead Eagles | Dutch Eredivisie |
| 9 | Thu 2 Dec 2021 | 200-5 v AjaxAjax 5-0 Willem II | Dutch Eredivisie |
| 10 | Sat 18 Dec 2021 | 201-4 v AZ AlkmaarAZ Alkmaar 4-1 Willem II | Dutch Eredivisie |
| 11 | Wed 22 Dec 2021 | 200-1 v NEC NijmegenWillem II 0-1 NEC Nijmegen | Dutch Eredivisie |
| 12 | Fri 14 Jan 2022 | 200-2 v PEC ZwollePEC Zwolle 2-0 Willem II | Dutch Eredivisie |
| 13 | Sat 22 Jan 2022 | 200-1 v FC TwenteWillem II 0-1 FC Twente | Dutch Eredivisie |
| 14 | Sat 19 Feb 2022 | 200-1 v AjaxWillem II 0-1 Ajax | Dutch Eredivisie |
| 15 | Sat 26 Feb 2022 | 200-1 v FC GroningenFC Groningen 1-0 Willem II | Dutch Eredivisie |
| 16 | Sat 5 Mar 2022 | 200-0 v sc HeerenveenWillem II 0-0 sc Heerenveen | Dutch Eredivisie |
| 17 | Sun 13 Mar 2022 | 200-1 v Fortuna SittardFortuna Sittard 1-0 Willem II | Dutch Eredivisie |
| 18 | Sat 2 Apr 2022 | 200-2 v FeyenoordFeyenoord 2-0 Willem II | Dutch Eredivisie |
| 19 | Fri 8 Apr 2022 | 200-4 v Go Ahead EaglesGo Ahead Eagles 4-0 Willem II | Dutch Eredivisie |
| 20 | Sun 24 Apr 2022 | 201-0 v VitesseWillem II 1-0 Vitesse | Dutch Eredivisie |
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