| 1 | Fri 13 Aug 2021 | 50-1 v sc HeerenveenGo Ahead Eagles 0-1 sc Heerenveen | Dutch Eredivisie |
| 2 | Sun 22 Aug 2021 | 5 0-2 v FeyenoordFeyenoord 2-0 Go Ahead Eagles | Dutch Eredivisie |
| 3 | Sat 28 Aug 2021 | 52-0 v Sparta RotterdamGo Ahead Eagles 2-0 Sparta Rotterdam | Dutch Eredivisie |
| 4 | Sun 19 Sep 2021 | 5 1-0 v PEC ZwolleGo Ahead Eagles 1-0 PEC Zwolle | Dutch Eredivisie |
| 5 | Wed 22 Sep 2021 | 51-2 v PSV EindhovenGo Ahead Eagles 1-2 PSV Eindhoven | Dutch Eredivisie |
| 6 | Sun 26 Sep 2021 | 50-5 v AZ AlkmaarAZ Alkmaar 5-0 Go Ahead Eagles | Dutch Eredivisie |
| 7 | Sat 2 Oct 2021 | 51-1 v RKC WaalwijkRKC Waalwijk 1-1 Go Ahead Eagles | Dutch Eredivisie |
| 8 | Sat 16 Oct 2021 | 54-2 v Heracles AlmeloGo Ahead Eagles 4-2 Heracles Almelo | Dutch Eredivisie |
| 9 | Sun 24 Oct 2021 | 52-1 v VitesseVitesse 1-2 Go Ahead Eagles | Dutch Eredivisie |
| 10 | Sun 31 Oct 2021 | 54-3 v Fortuna SittardGo Ahead Eagles 4-3 Fortuna Sittard | Dutch Eredivisie |
| 11 | Sun 7 Nov 2021 | 50-0 v AjaxAjax 0-0 Go Ahead Eagles | Dutch Eredivisie |
| 12 | Sat 11 Dec 2021 | 50-0 v FC UtrechtFC Utrecht 0-0 Go Ahead Eagles | Dutch Eredivisie |
| 13 | Sun 19 Dec 2021 | 50-2 v NEC NijmegenGo Ahead Eagles 0-2 NEC Nijmegen | Dutch Eredivisie |
| 14 | Thu 23 Dec 2021 | 50-2 v PSV EindhovenPSV Eindhoven 2-0 Go Ahead Eagles | Dutch Eredivisie |
| 15 | Sat 15 Jan 2022 | 5 0-2 v RKC WaalwijkGo Ahead Eagles 0-2 RKC Waalwijk | Dutch Eredivisie |
| 16 | Sun 23 Jan 2022 | 51-1 v Heracles AlmeloHeracles Almelo 1-1 Go Ahead Eagles | Dutch Eredivisie |
| 17 | Sun 6 Feb 2022 | 5 1-2 v FC GroningenFC Groningen 2-1 Go Ahead Eagles | Dutch Eredivisie |
| 18 | Sun 13 Feb 2022 | 51-4 v AZ AlkmaarGo Ahead Eagles 1-4 AZ Alkmaar | Dutch Eredivisie |
| 19 | Sun 20 Feb 2022 | 5 2-2 v FC TwenteFC Twente 2-2 Go Ahead Eagles | Dutch Eredivisie |
| 20 | Sat 5 Mar 2022 | 51-1 v FC UtrechtGo Ahead Eagles 1-1 FC Utrecht | Dutch Eredivisie |
| 21 | Sat 12 Mar 2022 | 50-1 v Sparta RotterdamSparta Rotterdam 1-0 Go Ahead Eagles | Dutch Eredivisie |
| 22 | Sun 3 Apr 2022 | 51-0 v PEC ZwollePEC Zwolle 0-1 Go Ahead Eagles | Dutch Eredivisie |
| 23 | Fri 8 Apr 2022 | 54-0 v Willem IIGo Ahead Eagles 4-0 Willem II | Dutch Eredivisie |
| 24 | Sun 24 Apr 2022 | 50-1 v Fortuna SittardFortuna Sittard 1-0 Go Ahead Eagles | Dutch Eredivisie |
| 25 | Sun 1 May 2022 | 51-2 v VitesseGo Ahead Eagles 1-2 Vitesse | Dutch Eredivisie |
| 26 | Sun 8 May 2022 | 50-1 v NEC NijmegenNEC Nijmegen 1-0 Go Ahead Eagles | Dutch Eredivisie |
| 27 | Wed 11 May 2022 | 50-1 v FeyenoordGo Ahead Eagles 0-1 Feyenoord | Dutch Eredivisie |
| 28 | Sun 15 May 2022 | 51-3 v sc Heerenveensc Heerenveen 3-1 Go Ahead Eagles | Dutch Eredivisie |
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