| 1 | Sat 11 Sep 2021 | 41-0 v FC UtrechtFC Twente 1-0 FC Utrecht | Dutch Eredivisie |
| 2 | Sun 26 Sep 2021 | 43-2 v sc Heerenveensc Heerenveen 2-3 FC Twente | Dutch Eredivisie |
| 3 | Sun 17 Oct 2021 | 41-1 v Willem IIFC Twente 1-1 Willem II | Dutch Eredivisie |
| 4 | Sun 24 Oct 2021 | 41-2 v NEC NijmegenFC Twente 1-2 NEC Nijmegen | Dutch Eredivisie |
| 5 | Sat 30 Oct 2021 | 42-5 v PSV EindhovenPSV Eindhoven 5-2 FC Twente | Dutch Eredivisie |
| 6 | Fri 5 Nov 2021 | 41-0 v Heracles AlmeloFC Twente 1-0 Heracles Almelo | Dutch Eredivisie |
| 7 | Sat 20 Nov 2021 | 41-0 v Sparta RotterdamSparta Rotterdam 0-1 FC Twente | Dutch Eredivisie |
| 8 | Sun 28 Nov 2021 | 40-0 v FeyenoordFC Twente 0-0 Feyenoord | Dutch Eredivisie |
| 9 | Sat 18 Dec 2021 | 43-1 v PEC ZwollePEC Zwolle 1-3 FC Twente | Dutch Eredivisie |
| 10 | Wed 22 Dec 2021 | 41-1 v FC UtrechtFC Utrecht 1-1 FC Twente | Dutch Eredivisie |
| 11 | Sat 15 Jan 2022 | 42-0 v sc HeerenveenFC Twente 2-0 sc Heerenveen | Dutch Eredivisie |
| 12 | Sun 20 Feb 2022 | 4 2-2 v Go Ahead EaglesFC Twente 2-2 Go Ahead Eagles | Dutch Eredivisie |
| 13 | Fri 25 Feb 2022 | 42-1 v RKC WaalwijkRKC Waalwijk 1-2 FC Twente | Dutch Eredivisie |
| 14 | Sun 13 Mar 2022 | 41-0 v AZ AlkmaarAZ Alkmaar 0-1 FC Twente | Dutch Eredivisie |
| 15 | Sat 19 Mar 2022 | 41-0 v PEC ZwolleFC Twente 1-0 PEC Zwolle | Dutch Eredivisie |
| 16 | Sat 2 Apr 2022 | 43-3 v PSV EindhovenFC Twente 3-3 PSV Eindhoven | Dutch Eredivisie |
| 17 | Sat 9 Apr 2022 | 42-0 v NEC NijmegenNEC Nijmegen 0-2 FC Twente | Dutch Eredivisie |
| 18 | Fri 22 Apr 2022 | 42-0 v Sparta RotterdamFC Twente 2-0 Sparta Rotterdam | Dutch Eredivisie |
| 19 | Sat 30 Apr 2022 | 4 1-1 v Heracles AlmeloHeracles Almelo 1-1 FC Twente | Dutch Eredivisie |
| 20 | Sat 7 May 2022 | 41-2 v Fortuna SittardFC Twente 1-2 Fortuna Sittard | Dutch Eredivisie |
| 21 | Wed 11 May 2022 | 43-0 v FC GroningenFC Twente 3-0 FC Groningen | Dutch Eredivisie |
| 22 | Sun 15 May 2022 | 4 2-1 v FeyenoordFeyenoord 1-2 FC Twente | Dutch Eredivisie |
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