| 1 | Sat 14 Aug 2021 | 31-2 v Fortuna SittardFortuna Sittard 2-1 FC Twente | Dutch Eredivisie |
| 2 | Sun 22 Aug 2021 | 31-1 v AjaxFC Twente 1-1 Ajax | Dutch Eredivisie |
| 3 | Sat 11 Sep 2021 | 31-0 v FC UtrechtFC Twente 1-0 FC Utrecht | Dutch Eredivisie |
| 4 | Sun 19 Sep 2021 | 34-1 v VitesseVitesse 1-4 FC Twente | Dutch Eredivisie |
| 5 | Thu 23 Sep 2021 | 3 3-1 v AZ AlkmaarFC Twente 3-1 AZ Alkmaar | Dutch Eredivisie |
| 6 | Sun 26 Sep 2021 | 33-2 v sc Heerenveensc Heerenveen 2-3 FC Twente | Dutch Eredivisie |
| 7 | Fri 1 Oct 2021 | 31-1 v FC GroningenFC Groningen 1-1 FC Twente | Dutch Eredivisie |
| 8 | Sun 17 Oct 2021 | 31-1 v Willem IIFC Twente 1-1 Willem II | Dutch Eredivisie |
| 9 | Sun 24 Oct 2021 | 3 1-2 v NEC NijmegenFC Twente 1-2 NEC Nijmegen | Dutch Eredivisie |
| 10 | Sat 30 Oct 2021 | 32-5 v PSV EindhovenPSV Eindhoven 5-2 FC Twente | Dutch Eredivisie |
| 11 | Fri 5 Nov 2021 | 31-0 v Heracles AlmeloFC Twente 1-0 Heracles Almelo | Dutch Eredivisie |
| 12 | Sat 20 Nov 2021 | 31-0 v Sparta RotterdamSparta Rotterdam 0-1 FC Twente | Dutch Eredivisie |
| 13 | Sun 28 Nov 2021 | 30-0 v FeyenoordFC Twente 0-0 Feyenoord | Dutch Eredivisie |
| 14 | Sun 5 Dec 2021 | 32-1 v Go Ahead EaglesGo Ahead Eagles 1-2 FC Twente | Dutch Eredivisie |
| 15 | Sun 12 Dec 2021 | 32-1 v RKC WaalwijkFC Twente 2-1 RKC Waalwijk | Dutch Eredivisie |
| 16 | Sat 18 Dec 2021 | 33-1 v PEC ZwollePEC Zwolle 1-3 FC Twente | Dutch Eredivisie |
| 17 | Wed 22 Dec 2021 | 31-1 v FC UtrechtFC Utrecht 1-1 FC Twente | Dutch Eredivisie |
| 18 | Sat 15 Jan 2022 | 32-0 v sc HeerenveenFC Twente 2-0 sc Heerenveen | Dutch Eredivisie |
| 19 | Sat 22 Jan 2022 | 31-0 v Willem IIWillem II 0-1 FC Twente | Dutch Eredivisie |
| 20 | Sat 5 Feb 2022 | 33-0 v VitesseFC Twente 3-0 Vitesse | Dutch Eredivisie |
| 21 | Sun 13 Feb 2022 | 30-5 v AjaxAjax 5-0 FC Twente | Dutch Eredivisie |
| 22 | Sun 20 Feb 2022 | 32-2 v Go Ahead EaglesFC Twente 2-2 Go Ahead Eagles | Dutch Eredivisie |
| 23 | Fri 25 Feb 2022 | 32-1 v RKC WaalwijkRKC Waalwijk 1-2 FC Twente | Dutch Eredivisie |
| 24 | Sun 13 Mar 2022 | 3 1-0 v AZ AlkmaarAZ Alkmaar 0-1 FC Twente | Dutch Eredivisie |
| 25 | Sat 19 Mar 2022 | 31-0 v PEC ZwolleFC Twente 1-0 PEC Zwolle | Dutch Eredivisie |
| 26 | Sat 2 Apr 2022 | 33-3 v PSV EindhovenFC Twente 3-3 PSV Eindhoven | Dutch Eredivisie |
| 27 | Sat 9 Apr 2022 | 32-0 v NEC NijmegenNEC Nijmegen 0-2 FC Twente | Dutch Eredivisie |
| 28 | Fri 22 Apr 2022 | 32-0 v Sparta RotterdamFC Twente 2-0 Sparta Rotterdam | Dutch Eredivisie |
| 29 | Sat 30 Apr 2022 | 31-1 v Heracles AlmeloHeracles Almelo 1-1 FC Twente | Dutch Eredivisie |
| 30 | Sat 7 May 2022 | 3 1-2 v Fortuna SittardFC Twente 1-2 Fortuna Sittard | Dutch Eredivisie |
| 31 | Wed 11 May 2022 | 33-0 v FC GroningenFC Twente 3-0 FC Groningen | Dutch Eredivisie |
| 32 | Sun 15 May 2022 | 32-1 v FeyenoordFeyenoord 1-2 FC Twente | Dutch Eredivisie |
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