| 1 | Sat 5 Feb 2022 | 33 0-2 v Fortuna SittardFortuna Sittard 2-0 sc Heerenveen | Dutch Eredivisie |
| 2 | Sun 13 Feb 2022 | 33 0-1 v NEC Nijmegensc Heerenveen 0-1 NEC Nijmegen | Dutch Eredivisie |
| 3 | Sun 20 Feb 2022 | 331-3 v PSV EindhovenPSV Eindhoven 3-1 sc Heerenveen | Dutch Eredivisie |
| 4 | Sun 27 Feb 2022 | 331-2 v FC Utrechtsc Heerenveen 1-2 FC Utrecht | Dutch Eredivisie |
| 5 | Sat 5 Mar 2022 | 330-0 v Willem IIWillem II 0-0 sc Heerenveen | Dutch Eredivisie |
| 6 | Sat 12 Mar 2022 | 33 0-0 v RKC WaalwijkRKC Waalwijk 0-0 sc Heerenveen | Dutch Eredivisie |
| 7 | Fri 18 Mar 2022 | 332-0 v Heracles Almelosc Heerenveen 2-0 Heracles Almelo | Dutch Eredivisie |
| 8 | Sun 3 Apr 2022 | 331-1 v Sparta RotterdamSparta Rotterdam 1-1 sc Heerenveen | Dutch Eredivisie |
| 9 | Sun 10 Apr 2022 | 333-1 v FC Groningensc Heerenveen 3-1 FC Groningen | Dutch Eredivisie |
| 10 | Sat 23 Apr 2022 | 331-2 v AZ AlkmaarAZ Alkmaar 2-1 sc Heerenveen | Dutch Eredivisie |
| 11 | Sun 8 May 2022 | 332-1 v VitesseVitesse 1-2 sc Heerenveen | Dutch Eredivisie |
| 12 | Wed 11 May 2022 | 330-5 v AjaxAjax 5-0 sc Heerenveen | Dutch Eredivisie |
| 13 | Sun 15 May 2022 | 333-1 v Go Ahead Eaglessc Heerenveen 3-1 Go Ahead Eagles | Dutch Eredivisie |
| 14 | Thu 19 May 2022 | 33 3-2 v AZ Alkmaarsc Heerenveen 3-2 AZ Alkmaar | Dutch Eredivisie Play-off |
| 15 | Sun 22 May 2022 | 330-2 v AZ AlkmaarAZ Alkmaar 2-0 sc Heerenveen | Dutch Eredivisie Play-off |
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