| 1 | Sun 12 Sep 2021 | 100-0 v NEC NijmegenNEC Nijmegen 0-0 Willem II | Dutch Eredivisie |
| 2 | Sat 18 Sep 2021 | 102-1 v FC GroningenWillem II 2-1 FC Groningen | Dutch Eredivisie |
| 3 | Sat 25 Sep 2021 | 102-1 v PSV EindhovenWillem II 2-1 PSV Eindhoven | Dutch Eredivisie |
| 4 | Sat 2 Oct 2021 | 102-3 v Heracles AlmeloHeracles Almelo 3-2 Willem II | Dutch Eredivisie |
| 5 | Sun 17 Oct 2021 | 101-1 v FC TwenteFC Twente 1-1 Willem II | Dutch Eredivisie |
| 6 | Sun 31 Oct 2021 | 101-5 v FC UtrechtFC Utrecht 5-1 Willem II | Dutch Eredivisie |
| 7 | Sat 6 Nov 2021 | 100-3 v Sparta RotterdamWillem II 0-3 Sparta Rotterdam | Dutch Eredivisie |
| 8 | Sun 21 Nov 2021 | 101-2 v sc Heerenveensc Heerenveen 2-1 Willem II | Dutch Eredivisie |
| 9 | Sat 27 Nov 2021 | 100-1 v Go Ahead EaglesWillem II 0-1 Go Ahead Eagles | Dutch Eredivisie |
| 10 | Wed 22 Dec 2021 | 100-1 v NEC NijmegenWillem II 0-1 NEC Nijmegen | Dutch Eredivisie |
| 11 | Fri 14 Jan 2022 | 100-2 v PEC ZwollePEC Zwolle 2-0 Willem II | Dutch Eredivisie |
| 12 | Sat 22 Jan 2022 | 100-1 v FC TwenteWillem II 0-1 FC Twente | Dutch Eredivisie |
| 13 | Sun 6 Feb 2022 | 103-1 v RKC WaalwijkWillem II 3-1 RKC Waalwijk | Dutch Eredivisie |
| 14 | Sat 19 Feb 2022 | 100-1 v AjaxWillem II 0-1 Ajax | Dutch Eredivisie |
| 15 | Sat 26 Feb 2022 | 100-1 v FC GroningenFC Groningen 1-0 Willem II | Dutch Eredivisie |
| 16 | Fri 8 Apr 2022 | 100-4 v Go Ahead EaglesGo Ahead Eagles 4-0 Willem II | Dutch Eredivisie |
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