| 1 | Fri 13 Aug 2021 | 41-0 v Go Ahead EaglesGo Ahead Eagles 0-1 sc Heerenveen | Dutch Eredivisie |
| 2 | Sat 21 Aug 2021 | 43-2 v RKC Waalwijksc Heerenveen 3-2 RKC Waalwijk | Dutch Eredivisie |
| 3 | Sun 29 Aug 2021 | 41-3 v AZ Alkmaarsc Heerenveen 1-3 AZ Alkmaar | Dutch Eredivisie |
| 4 | Sun 12 Sep 2021 | 41-1 v FC GroningenFC Groningen 1-1 sc Heerenveen | Dutch Eredivisie |
| 5 | Sat 18 Sep 2021 | 41-0 v Fortuna Sittardsc Heerenveen 1-0 Fortuna Sittard | Dutch Eredivisie |
| 6 | Wed 22 Sep 2021 | 41-3 v FeyenoordFeyenoord 3-1 sc Heerenveen | Dutch Eredivisie |
| 7 | Sun 26 Sep 2021 | 42-3 v FC Twentesc Heerenveen 2-3 FC Twente | Dutch Eredivisie |
| 8 | Sat 2 Oct 2021 | 41-0 v PEC ZwollePEC Zwolle 0-1 sc Heerenveen | Dutch Eredivisie |
| 9 | Sat 16 Oct 2021 | 4 0-2 v Ajaxsc Heerenveen 0-2 Ajax | Dutch Eredivisie |
| 10 | Sat 30 Oct 2021 | 41-2 v Vitessesc Heerenveen 1-2 Vitesse | Dutch Eredivisie |
| 11 | Sun 28 Nov 2021 | 41-1 v PSV Eindhovensc Heerenveen 1-1 PSV Eindhoven | Dutch Eredivisie |
| 12 | Sat 4 Dec 2021 | 4 1-0 v Heracles AlmeloHeracles Almelo 0-1 sc Heerenveen | Dutch Eredivisie |
| 13 | Sat 11 Dec 2021 | 40-0 v Sparta Rotterdamsc Heerenveen 0-0 Sparta Rotterdam | Dutch Eredivisie |
| 14 | Wed 22 Dec 2021 | 40-3 v Feyenoordsc Heerenveen 0-3 Feyenoord | Dutch Eredivisie |
| 15 | Sat 15 Jan 2022 | 40-2 v FC TwenteFC Twente 2-0 sc Heerenveen | Dutch Eredivisie |
| 16 | Sat 22 Jan 2022 | 40-1 v PEC Zwollesc Heerenveen 0-1 PEC Zwolle | Dutch Eredivisie |
| 17 | Sun 20 Feb 2022 | 41-3 v PSV EindhovenPSV Eindhoven 3-1 sc Heerenveen | Dutch Eredivisie |
| 18 | Sun 27 Feb 2022 | 41-2 v FC Utrechtsc Heerenveen 1-2 FC Utrecht | Dutch Eredivisie |
| 19 | Sat 5 Mar 2022 | 40-0 v Willem IIWillem II 0-0 sc Heerenveen | Dutch Eredivisie |
| 20 | Sat 12 Mar 2022 | 4 0-0 v RKC WaalwijkRKC Waalwijk 0-0 sc Heerenveen | Dutch Eredivisie |
| 21 | Fri 18 Mar 2022 | 42-0 v Heracles Almelosc Heerenveen 2-0 Heracles Almelo | Dutch Eredivisie |
| 22 | Sun 3 Apr 2022 | 41-1 v Sparta RotterdamSparta Rotterdam 1-1 sc Heerenveen | Dutch Eredivisie |
| 23 | Sun 10 Apr 2022 | 43-1 v FC Groningensc Heerenveen 3-1 FC Groningen | Dutch Eredivisie |
| 24 | Sat 23 Apr 2022 | 41-2 v AZ AlkmaarAZ Alkmaar 2-1 sc Heerenveen | Dutch Eredivisie |
| 25 | Sun 8 May 2022 | 42-1 v VitesseVitesse 1-2 sc Heerenveen | Dutch Eredivisie |
| 26 | Wed 11 May 2022 | 40-5 v AjaxAjax 5-0 sc Heerenveen | Dutch Eredivisie |
| 27 | Sun 15 May 2022 | 43-1 v Go Ahead Eaglessc Heerenveen 3-1 Go Ahead Eagles | Dutch Eredivisie |
| 28 | Thu 19 May 2022 | 43-2 v AZ Alkmaarsc Heerenveen 3-2 AZ Alkmaar | Dutch Eredivisie Play-off |
| 29 | Sun 22 May 2022 | 40-2 v AZ AlkmaarAZ Alkmaar 2-0 sc Heerenveen | Dutch Eredivisie Play-off |
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