| 1 | Sun 15 Aug 2021 | 140-4 v FeyenoordWillem II 0-4 Feyenoord | Dutch Eredivisie |
| 2 | Sun 22 Aug 2021 | 14 3-0 v VitesseVitesse 0-3 Willem II | Dutch Eredivisie |
| 3 | Sat 28 Aug 2021 | 141-0 v PEC ZwolleWillem II 1-0 PEC Zwolle | Dutch Eredivisie |
| 4 | Tue 21 Sep 2021 | 142-1 v RKC WaalwijkRKC Waalwijk 1-2 Willem II | Dutch Eredivisie |
| 5 | Thu 2 Dec 2021 | 140-5 v AjaxAjax 5-0 Willem II | Dutch Eredivisie |
| 6 | Sat 18 Dec 2021 | 141-4 v AZ AlkmaarAZ Alkmaar 4-1 Willem II | Dutch Eredivisie |
| 7 | Wed 22 Dec 2021 | 140-1 v NEC NijmegenWillem II 0-1 NEC Nijmegen | Dutch Eredivisie |
| 8 | Fri 14 Jan 2022 | 140-2 v PEC ZwollePEC Zwolle 2-0 Willem II | Dutch Eredivisie |
| 9 | Sat 22 Jan 2022 | 140-1 v FC TwenteWillem II 0-1 FC Twente | Dutch Eredivisie |
| 10 | Sun 6 Feb 2022 | 143-1 v RKC WaalwijkWillem II 3-1 RKC Waalwijk | Dutch Eredivisie |
| 11 | Sun 13 Feb 2022 | 140-1 v Sparta RotterdamSparta Rotterdam 1-0 Willem II | Dutch Eredivisie |
| 12 | Sat 19 Feb 2022 | 140-1 v AjaxWillem II 0-1 Ajax | Dutch Eredivisie |
| 13 | Sat 26 Feb 2022 | 140-1 v FC GroningenFC Groningen 1-0 Willem II | Dutch Eredivisie |
| 14 | Sat 5 Mar 2022 | 140-0 v sc HeerenveenWillem II 0-0 sc Heerenveen | Dutch Eredivisie |
| 15 | Sun 13 Mar 2022 | 140-1 v Fortuna SittardFortuna Sittard 1-0 Willem II | Dutch Eredivisie |
| 16 | Sun 20 Mar 2022 | 142-2 v AZ AlkmaarWillem II 2-2 AZ Alkmaar | Dutch Eredivisie |
| 17 | Sat 2 Apr 2022 | 140-2 v FeyenoordFeyenoord 2-0 Willem II | Dutch Eredivisie |
| 18 | Fri 8 Apr 2022 | 140-4 v Go Ahead EaglesGo Ahead Eagles 4-0 Willem II | Dutch Eredivisie |
| 19 | Sun 24 Apr 2022 | 141-0 v VitesseWillem II 1-0 Vitesse | Dutch Eredivisie |
| 20 | Sun 1 May 2022 | 142-4 v PSV EindhovenPSV Eindhoven 4-2 Willem II | Dutch Eredivisie |
| 21 | Sat 7 May 2022 | 142-0 v Heracles AlmeloWillem II 2-0 Heracles Almelo | Dutch Eredivisie |
| 22 | Sun 15 May 2022 | 143-0 v FC UtrechtWillem II 3-0 FC Utrecht | Dutch Eredivisie |
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