| 1 | Sun 15 Aug 2021 | 40-4 v FeyenoordWillem II 0-4 Feyenoord | Dutch Eredivisie |
| 2 | Sun 22 Aug 2021 | 43-0 v VitesseVitesse 0-3 Willem II | Dutch Eredivisie |
| 3 | Sat 28 Aug 2021 | 41-0 v PEC ZwolleWillem II 1-0 PEC Zwolle | Dutch Eredivisie |
| 4 | Sun 12 Sep 2021 | 4 0-0 v NEC NijmegenNEC Nijmegen 0-0 Willem II | Dutch Eredivisie |
| 5 | Sat 18 Sep 2021 | 42-1 v FC GroningenWillem II 2-1 FC Groningen | Dutch Eredivisie |
| 6 | Tue 21 Sep 2021 | 42-1 v RKC WaalwijkRKC Waalwijk 1-2 Willem II | Dutch Eredivisie |
| 7 | Sat 25 Sep 2021 | 42-1 v PSV EindhovenWillem II 2-1 PSV Eindhoven | Dutch Eredivisie |
| 8 | Sat 2 Oct 2021 | 42-3 v Heracles AlmeloHeracles Almelo 3-2 Willem II | Dutch Eredivisie |
| 9 | Sun 17 Oct 2021 | 41-1 v FC TwenteFC Twente 1-1 Willem II | Dutch Eredivisie |
| 10 | Fri 22 Oct 2021 | 41-1 v Fortuna SittardWillem II 1-1 Fortuna Sittard | Dutch Eredivisie |
| 11 | Sun 31 Oct 2021 | 41-5 v FC UtrechtFC Utrecht 5-1 Willem II | Dutch Eredivisie |
| 12 | Sat 6 Nov 2021 | 40-3 v Sparta RotterdamWillem II 0-3 Sparta Rotterdam | Dutch Eredivisie |
| 13 | Sun 21 Nov 2021 | 41-2 v sc Heerenveensc Heerenveen 2-1 Willem II | Dutch Eredivisie |
| 14 | Sat 27 Nov 2021 | 40-1 v Go Ahead EaglesWillem II 0-1 Go Ahead Eagles | Dutch Eredivisie |
| 15 | Thu 2 Dec 2021 | 40-5 v AjaxAjax 5-0 Willem II | Dutch Eredivisie |
| 16 | Sat 18 Dec 2021 | 41-4 v AZ AlkmaarAZ Alkmaar 4-1 Willem II | Dutch Eredivisie |
| 17 | Wed 22 Dec 2021 | 4 0-1 v NEC NijmegenWillem II 0-1 NEC Nijmegen | Dutch Eredivisie |
| 18 | Sat 22 Jan 2022 | 4 0-1 v FC TwenteWillem II 0-1 FC Twente | Dutch Eredivisie |
| 19 | Sun 6 Feb 2022 | 43-1 v RKC WaalwijkWillem II 3-1 RKC Waalwijk | Dutch Eredivisie |
| 20 | Sat 19 Feb 2022 | 40-1 v AjaxWillem II 0-1 Ajax | Dutch Eredivisie |
| 21 | Sun 1 May 2022 | 42-4 v PSV EindhovenPSV Eindhoven 4-2 Willem II | Dutch Eredivisie |
| 22 | Sun 15 May 2022 | 43-0 v FC UtrechtWillem II 3-0 FC Utrecht | Dutch Eredivisie |
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