| 1 | Sun 15 Aug 2021 | 11-0 v PEC ZwollePEC Zwolle 0-1 Vitesse | Dutch Eredivisie |
| 2 | Sun 22 Aug 2021 | 10-3 v Willem IIVitesse 0-3 Willem II | Dutch Eredivisie |
| 3 | Thu 26 Aug 2021 | 1 2-1 v RSC AnderlechtVitesse 2-1 RSC Anderlecht | UEFA Europa Conference League |
| 4 | Sun 29 Aug 2021 | 10-5 v AjaxAjax 5-0 Vitesse | Dutch Eredivisie |
| 5 | Sun 12 Sep 2021 | 12-1 v RKC WaalwijkRKC Waalwijk 1-2 Vitesse | Dutch Eredivisie |
| 6 | Thu 16 Sep 2021 | 12-0 v Mura Murska SobotaMura Murska Sobota 0-2 Vitesse | UEFA Europa Conference League |
| 7 | Sun 19 Sep 2021 | 1 1-4 v FC TwenteVitesse 1-4 FC Twente | Dutch Eredivisie |
| 8 | Wed 22 Sep 2021 | 11-0 v FC GroningenFC Groningen 0-1 Vitesse | Dutch Eredivisie |
| 9 | Sat 25 Sep 2021 | 11-1 v Fortuna SittardVitesse 1-1 Fortuna Sittard | Dutch Eredivisie |
| 10 | Thu 30 Sep 2021 | 11-2 v RennesVitesse 1-2 Rennes | UEFA Europa Conference League |
| 11 | Sun 3 Oct 2021 | 12-1 v FeyenoordVitesse 2-1 Feyenoord | Dutch Eredivisie |
| 12 | Sun 17 Oct 2021 | 11-0 v NEC NijmegenNEC Nijmegen 0-1 Vitesse | Dutch Eredivisie |
| 13 | Thu 21 Oct 2021 | 11-0 v Tottenham HotspurVitesse 1-0 Tottenham Hotspur | UEFA Europa Conference League |
| 14 | Sun 24 Oct 2021 | 11-2 v Go Ahead EaglesVitesse 1-2 Go Ahead Eagles | Dutch Eredivisie |
| 15 | Sat 30 Oct 2021 | 12-1 v sc Heerenveensc Heerenveen 1-2 Vitesse | Dutch Eredivisie |
| 16 | Thu 4 Nov 2021 | 1 2-3 v Tottenham HotspurTottenham Hotspur 3-2 Vitesse | UEFA Europa Conference League |
| 17 | Sun 7 Nov 2021 | 12-1 v FC UtrechtVitesse 2-1 FC Utrecht | Dutch Eredivisie |
| 18 | Sat 20 Nov 2021 | 10-2 v PSV EindhovenPSV Eindhoven 2-0 Vitesse | Dutch Eredivisie |
| 19 | Sun 28 Nov 2021 | 10-0 v AZ AlkmaarVitesse 0-0 AZ Alkmaar | Dutch Eredivisie |
| 20 | Sun 13 Mar 2022 | 10-0 v Heracles AlmeloHeracles Almelo 0-0 Vitesse | Dutch Eredivisie |
| 21 | Sun 24 Apr 2022 | 10-1 v Willem IIWillem II 1-0 Vitesse | Dutch Eredivisie |
| 22 | Sun 1 May 2022 | 12-1 v Go Ahead EaglesGo Ahead Eagles 1-2 Vitesse | Dutch Eredivisie |
| 23 | Sun 8 May 2022 | 11-2 v sc HeerenveenVitesse 1-2 sc Heerenveen | Dutch Eredivisie |
| 24 | Wed 11 May 2022 | 12-1 v Fortuna SittardFortuna Sittard 1-2 Vitesse | Dutch Eredivisie |
| 25 | Sun 15 May 2022 | 12-2 v AjaxVitesse 2-2 Ajax | Dutch Eredivisie |
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