| 1 | Sat 31 Jul 2021 | 22-1 v CSKA MoscowCSKA Moscow 1-2 Lokomotiv Moscow | Russian Premier League |
| 2 | Fri 6 Aug 2021 | 21-1 v UfaUfa 1-1 Lokomotiv Moscow | Russian Premier League |
| 3 | Sun 15 Aug 2021 | 21-1 v Zenit St PetersburgLokomotiv Moscow 1-1 Zenit St Petersburg | Russian Premier League |
| 4 | Fri 27 Aug 2021 | 21-1 v Dinamo MoscowDinamo Moscow 1-1 Lokomotiv Moscow | Russian Premier League |
| 5 | Sat 11 Sep 2021 | 2 2-0 v Krylia SovetovLokomotiv Moscow 2-0 Krylia Sovetov | Russian Premier League |
| 6 | Thu 30 Sep 2021 | 20-2 v LazioLazio 2-0 Lokomotiv Moscow | UEFA Europa League Group E |
| 7 | Sun 3 Oct 2021 | 21-2 v RostovLokomotiv Moscow 1-2 Rostov | Russian Premier League |
| 8 | Sat 16 Oct 2021 | 22-2 v Rubin KazanRubin Kazan 2-2 Lokomotiv Moscow | Russian Premier League |
| 9 | Thu 21 Oct 2021 | 20-1 v GalatasarayLokomotiv Moscow 0-1 Galatasaray | UEFA Europa League Group E |
| 10 | Sat 30 Oct 2021 | 22-1 v Nizhny NovgorodNizhny Novgorod 1-2 Lokomotiv Moscow | Russian Premier League |
| 11 | Thu 4 Nov 2021 | 2 1-1 v GalatasarayGalatasaray 1-1 Lokomotiv Moscow | UEFA Europa League Group E |
| 12 | Sun 7 Nov 2021 | 2 1-1 v Spartak MoscowSpartak Moscow 1-1 Lokomotiv Moscow | Russian Premier League |
| 13 | Sun 6 Mar 2022 | 23-2 v KhimkiLokomotiv Moscow 3-2 Khimki | Russian Premier League |
| 14 | Sat 12 Mar 2022 | 21-2 v CSKA MoscowLokomotiv Moscow 1-2 CSKA Moscow | Russian Premier League |
| 15 | Sat 19 Mar 2022 | 23-2 v Akhmat GroznyAkhmat Grozny 2-3 Lokomotiv Moscow | Russian Premier League |
| 16 | Sat 2 Apr 2022 | 21-0 v Spartak MoscowLokomotiv Moscow 1-0 Spartak Moscow | Russian Premier League |
| 17 | Sun 10 Apr 2022 | 2 1-4 v RostovRostov 4-1 Lokomotiv Moscow | Russian Premier League |
| 18 | Sun 17 Apr 2022 | 22-2 v SochiSochi 2-2 Lokomotiv Moscow | Russian Premier League |
| 19 | Sat 23 Apr 2022 | 2 2-1 v Nizhny NovgorodLokomotiv Moscow 2-1 Nizhny Novgorod | Russian Premier League |
| 20 | Wed 4 May 2022 | 20-1 v FK KrasnodarFK Krasnodar 1-0 Lokomotiv Moscow | Russian Premier League |
| 21 | Sun 8 May 2022 | 21-0 v Rubin KazanLokomotiv Moscow 1-0 Rubin Kazan | Russian Premier League |
| 22 | Sat 14 May 2022 | 2 3-3 v Dinamo MoscowLokomotiv Moscow 3-3 Dinamo Moscow | Russian Premier League |
| 23 | Sat 21 May 2022 | 21-0 v Krylia SovetovKrylia Sovetov 0-1 Lokomotiv Moscow | Russian Premier League |
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