| 1 | Sun 1 Aug 2021 | 4 4-2 v RostovRostov 2-4 Zenit St Petersburg | Russian Premier League |
| 2 | Sat 7 Aug 2021 | 43-2 v FK KrasnodarZenit St Petersburg 3-2 FK Krasnodar | Russian Premier League |
| 3 | Sun 15 Aug 2021 | 41-1 v Lokomotiv MoscowLokomotiv Moscow 1-1 Zenit St Petersburg | Russian Premier League |
| 4 | Sat 11 Sep 2021 | 43-1 v Akhmat GroznyZenit St Petersburg 3-1 Akhmat Grozny | Russian Premier League |
| 5 | Tue 14 Sep 2021 | 40-1 v ChelseaChelsea 1-0 Zenit St Petersburg | UEFA Champions League Group H |
| 6 | Mon 20 Sep 2021 | 43-1 v Rubin KazanRubin Kazan 1-3 Zenit St Petersburg | Russian Premier League |
| 7 | Sat 25 Sep 2021 | 42-1 v Krylia SovetovZenit St Petersburg 2-1 Krylia Sovetov | Russian Premier League |
| 8 | Wed 29 Sep 2021 | 44-0 v Malmö FFZenit St Petersburg 4-0 Malmö FF | UEFA Champions League Group H |
| 9 | Sun 3 Oct 2021 | 41-2 v SochiZenit St Petersburg 1-2 Sochi | Russian Premier League |
| 10 | Sat 16 Oct 2021 | 41-2 v Arsenal TulaArsenal Tula 2-1 Zenit St Petersburg | Russian Premier League |
| 11 | Wed 20 Oct 2021 | 40-1 v JuventusZenit St Petersburg 0-1 Juventus | UEFA Champions League Group H |
| 12 | Sun 24 Oct 2021 | 47-1 v Spartak MoscowZenit St Petersburg 7-1 Spartak Moscow | Russian Premier League |
| 13 | Tue 2 Nov 2021 | 42-4 v JuventusJuventus 4-2 Zenit St Petersburg | UEFA Champions League Group H |
| 14 | Sun 7 Nov 2021 | 40-0 v UralUral 0-0 Zenit St Petersburg | Russian Premier League |
| 15 | Fri 19 Nov 2021 | 45-1 v Nizhny NovgorodZenit St Petersburg 5-1 Nizhny Novgorod | Russian Premier League |
| 16 | Tue 23 Nov 2021 | 41-1 v Malmö FFMalmö FF 1-1 Zenit St Petersburg | UEFA Champions League Group H |
| 17 | Sun 28 Nov 2021 | 42-0 v CSKA MoscowCSKA Moscow 0-2 Zenit St Petersburg | Russian Premier League |
| 18 | Wed 8 Dec 2021 | 43-3 v ChelseaZenit St Petersburg 3-3 Chelsea | UEFA Champions League Group H |
| 19 | Sun 12 Dec 2021 | 41-1 v Dinamo MoscowDinamo Moscow 1-1 Zenit St Petersburg | Russian Premier League |
| 20 | Thu 17 Feb 2022 | 42-3 v Real BetisZenit St Petersburg 2-3 Real Betis | UEFA Europa League Round of 32 |
| 21 | Thu 24 Feb 2022 | 4 0-0 v Real BetisReal Betis 0-0 Zenit St Petersburg | UEFA Europa League Round of 32 |
| 22 | Mon 28 Feb 2022 | 43-2 v Rubin KazanZenit St Petersburg 3-2 Rubin Kazan | Russian Premier League |
| 23 | Mon 7 Mar 2022 | 42-0 v UfaZenit St Petersburg 2-0 Ufa | Russian Premier League |
| 24 | Sun 13 Mar 2022 | 41-1 v Krylia SovetovKrylia Sovetov 1-1 Zenit St Petersburg | Russian Premier League |
| 25 | Sat 19 Mar 2022 | 43-0 v Arsenal TulaZenit St Petersburg 3-0 Arsenal Tula | Russian Premier League |
| 26 | Sun 3 Apr 2022 | 40-0 v SochiSochi 0-0 Zenit St Petersburg | Russian Premier League |
| 27 | Sat 9 Apr 2022 | 42-0 v Akhmat GroznyAkhmat Grozny 0-2 Zenit St Petersburg | Russian Premier League |
| 28 | Sat 16 Apr 2022 | 4 3-1 v UralZenit St Petersburg 3-1 Ural | Russian Premier League |
| 29 | Mon 25 Apr 2022 | 43-1 v FK KrasnodarFK Krasnodar 1-3 Zenit St Petersburg | Russian Premier League |
| 30 | Sat 30 Apr 2022 | 43-1 v Lokomotiv MoscowZenit St Petersburg 3-1 Lokomotiv Moscow | Russian Premier League |
| 31 | Sat 7 May 2022 | 41-0 v KhimkiZenit St Petersburg 1-0 Khimki | Russian Premier League |
| 32 | Sun 15 May 2022 | 41-1 v Spartak MoscowSpartak Moscow 1-1 Zenit St Petersburg | Russian Premier League |
| 33 | Sat 21 May 2022 | 40-1 v Nizhny NovgorodNizhny Novgorod 1-0 Zenit St Petersburg | Russian Premier League |
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