| 1 | Sat 7 Aug 2021 | 30-2 v Rotherham UnitedRotherham United 2-0 Plymouth Argyle | Sky Bet League One |
| 2 | Sat 14 Aug 2021 | 31-0 v GillinghamPlymouth Argyle 1-0 Gillingham | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 31-1 v Cambridge UnitedPlymouth Argyle 1-1 Cambridge United | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 33-0 v Shrewsbury TownShrewsbury Town 0-3 Plymouth Argyle | Sky Bet League One |
| 5 | Tue 24 Aug 2021 | 31-4 v Swansea CitySwansea City 4-1 Plymouth Argyle | Carabao Cup Second Round |
| 6 | Sat 28 Aug 2021 | 31-1 v Fleetwood TownPlymouth Argyle 1-1 Fleetwood Town | Sky Bet League One |
| 7 | Sat 25 Sep 2021 | 32-1 v Doncaster RoversPlymouth Argyle 2-1 Doncaster Rovers | Sky Bet League One |
| 8 | Tue 28 Sep 2021 | 31-1 v Crewe AlexandraPlymouth Argyle 1-1 Crewe Alexandra | Sky Bet League One |
| 9 | Sat 2 Oct 2021 | 32-2 v Lincoln CityLincoln City 2-2 Plymouth Argyle | Sky Bet League One |
| 10 | Sat 9 Oct 2021 | 32-1 v Burton AlbionPlymouth Argyle 2-1 Burton Albion | Sky Bet League One |
| 11 | Tue 12 Oct 2021 | 31-3 v Swindon TownPlymouth Argyle 1-3 Swindon Town | Papa John’s Trophy |
| 12 | Sat 16 Oct 2021 | 33-1 v Oxford UnitedOxford United 1-3 Plymouth Argyle | Sky Bet League One |
| 13 | Sat 30 Oct 2021 | 32-1 v Ipswich TownPlymouth Argyle 2-1 Ipswich Town | Sky Bet League One |
| 14 | Sat 13 Nov 2021 | 34-1 v Accrington StanleyAccrington Stanley 1-4 Plymouth Argyle | Sky Bet League One |
| 15 | Tue 16 Nov 2021 | 33-0 v Sheffield WednesdayPlymouth Argyle 3-0 Sheffield Wednesday | Emirates FA Cup First Round Replay |
| 16 | Sat 20 Nov 2021 | 3 0-2 v Charlton AthleticCharlton Athletic 2-0 Plymouth Argyle | Sky Bet League One |
| 17 | Tue 23 Nov 2021 | 30-3 v Wycombe WanderersPlymouth Argyle 0-3 Wycombe Wanderers | Sky Bet League One |
| 18 | Sat 27 Nov 2021 | 31-2 v Wigan AthleticPlymouth Argyle 1-2 Wigan Athletic | Sky Bet League One |
| 19 | Sun 5 Dec 2021 | 32-1 v RochdaleRochdale 1-2 Plymouth Argyle | Emirates FA Cup Second Round |
| 20 | Wed 8 Dec 2021 | 31-1 v Milton Keynes DonsMilton Keynes Dons 1-1 Plymouth Argyle | Sky Bet League One |
| 21 | Sat 11 Dec 2021 | 31-2 v SunderlandSunderland 2-1 Plymouth Argyle | Sky Bet League One |
| 22 | Sat 18 Dec 2021 | 31-0 v Charlton AthleticPlymouth Argyle 1-0 Charlton Athletic | Sky Bet League One |
| 23 | Sun 26 Dec 2021 | 32-0 v Cheltenham TownCheltenham Town 0-2 Plymouth Argyle | Sky Bet League One |
| 24 | Sat 8 Jan 2022 | 31-0 v Birmingham CityBirmingham City 0-1 Plymouth Argyle | Emirates FA Cup Third Round |
| 25 | Sat 15 Jan 2022 | 32-4 v Sheffield WednesdaySheffield Wednesday 4-2 Plymouth Argyle | Sky Bet League One |
| 26 | Tue 25 Jan 2022 | 33-3 v Fleetwood TownFleetwood Town 3-3 Plymouth Argyle | Sky Bet League One |
| 27 | Sat 29 Jan 2022 | 33-1 v Doncaster RoversDoncaster Rovers 1-3 Plymouth Argyle | Sky Bet League One |
| 28 | Sat 5 Feb 2022 | 31-2 v ChelseaChelsea 2-1 Plymouth Argyle | Emirates FA Cup Fourth Round |
| 29 | Tue 8 Feb 2022 | 34-1 v Crewe AlexandraCrewe Alexandra 1-4 Plymouth Argyle | Sky Bet League One |
| 30 | Sat 12 Feb 2022 | 31-0 v Shrewsbury TownPlymouth Argyle 1-0 Shrewsbury Town | Sky Bet League One |
| 31 | Sat 19 Feb 2022 | 32-0 v GillinghamGillingham 0-2 Plymouth Argyle | Sky Bet League One |
| 32 | Tue 22 Feb 2022 | 30-2 v Cambridge UnitedCambridge United 2-0 Plymouth Argyle | Sky Bet League One |
| 33 | Sat 26 Feb 2022 | 30-1 v Rotherham UnitedPlymouth Argyle 0-1 Rotherham United | Sky Bet League One |
| 34 | Sat 5 Mar 2022 | 32-0 v MorecambePlymouth Argyle 2-0 Morecambe | Sky Bet League One |
| 35 | Tue 8 Mar 2022 | 32-0 v AFC WimbledonPlymouth Argyle 2-0 AFC Wimbledon | Sky Bet League One |
| 36 | Sat 12 Mar 2022 | 31-0 v Bolton WanderersBolton Wanderers 0-1 Plymouth Argyle | Sky Bet League One |
| 37 | Tue 15 Mar 2022 | 31-0 v PortsmouthPlymouth Argyle 1-0 Portsmouth | Sky Bet League One |
| 38 | Sat 19 Mar 2022 | 34-0 v Accrington StanleyPlymouth Argyle 4-0 Accrington Stanley | Sky Bet League One |
| 39 | Tue 22 Mar 2022 | 32-0 v Cheltenham TownPlymouth Argyle 2-0 Cheltenham Town | Sky Bet League One |
| 40 | Sat 26 Mar 2022 | 30-1 v Ipswich TownIpswich Town 1-0 Plymouth Argyle | Sky Bet League One |
| 41 | Sat 2 Apr 2022 | 31-0 v Oxford UnitedPlymouth Argyle 1-0 Oxford United | Sky Bet League One |
| 42 | Sat 9 Apr 2022 | 30-0 v Burton AlbionBurton Albion 0-0 Plymouth Argyle | Sky Bet League One |
| 43 | Fri 15 Apr 2022 | 30-2 v Wycombe WanderersWycombe Wanderers 2-0 Plymouth Argyle | Sky Bet League One |
| 44 | Mon 18 Apr 2022 | 30-0 v SunderlandPlymouth Argyle 0-0 Sunderland | Sky Bet League One |
| 45 | Sat 23 Apr 2022 | 31-1 v Wigan AthleticWigan Athletic 1-1 Plymouth Argyle | Sky Bet League One |
| 46 | Sat 30 Apr 2022 | 30-5 v Milton Keynes DonsPlymouth Argyle 0-5 Milton Keynes Dons | Sky Bet League One |
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