| 1 | Thu 19 Aug 2021 | 33 0-1 v Paços de FerreiraPaços de Ferreira 1-0 Tottenham Hotspur | UEFA Europa Conference League |
| 2 | Thu 26 Aug 2021 | 333-0 v Paços de FerreiraTottenham Hotspur 3-0 Paços de Ferreira | UEFA Europa Conference League |
| 3 | Wed 1 Sep 2021 | 40-0 v FinlandFinland 0-0 Wales | International Friendly |
| 4 | Wed 8 Sep 2021 | 40-0 v EstoniaWales 0-0 Estonia | World Cup Qualification (Europe) |
| 5 | Sat 11 Sep 2021 | 330-3 v Crystal PalaceCrystal Palace 3-0 Tottenham Hotspur | Premier League |
| 6 | Thu 16 Sep 2021 | 332-2 v RennesRennes 2-2 Tottenham Hotspur | UEFA Europa Conference League |
| 7 | Wed 22 Sep 2021 | 332-2 v Wolverhampton WanderersWolverhampton Wanderers 2-2 Tottenham Hotspur | Carabao Cup Third Round |
| 8 | Thu 21 Oct 2021 | 330-1 v VitesseVitesse 1-0 Tottenham Hotspur | UEFA Europa Conference League |
| 9 | Wed 27 Oct 2021 | 331-0 v BurnleyBurnley 0-1 Tottenham Hotspur | Carabao Cup Round of 16 |
| 10 | Sat 30 Oct 2021 | 33 0-3 v Manchester UnitedTottenham Hotspur 0-3 Manchester United | Premier League |
| 11 | Thu 4 Nov 2021 | 333-2 v VitesseTottenham Hotspur 3-2 Vitesse | UEFA Europa Conference League |
| 12 | Sun 7 Nov 2021 | 330-0 v EvertonEverton 0-0 Tottenham Hotspur | Premier League |
| 13 | Sat 13 Nov 2021 | 45-1 v BelarusWales 5-1 Belarus | World Cup Qualification (Europe) |
| 14 | Tue 16 Nov 2021 | 41-1 v BelgiumWales 1-1 Belgium | World Cup Qualification (Europe) |
| 15 | Sun 21 Nov 2021 | 332-1 v Leeds UnitedTottenham Hotspur 2-1 Leeds United | Premier League |
| 16 | Thu 25 Nov 2021 | 331-2 v Mura Murska SobotaMura Murska Sobota 2-1 Tottenham Hotspur | UEFA Europa Conference League |
| 17 | Thu 2 Dec 2021 | 332-0 v BrentfordTottenham Hotspur 2-0 Brentford | Premier League |
| 18 | Sun 5 Dec 2021 | 333-0 v Norwich CityTottenham Hotspur 3-0 Norwich City | Premier League |
| 19 | Sun 19 Dec 2021 | 33 2-2 v LiverpoolTottenham Hotspur 2-2 Liverpool | Premier League |
| 20 | Wed 22 Dec 2021 | 332-1 v West Ham UnitedTottenham Hotspur 2-1 West Ham United | Carabao Cup Quarter Final |
| 21 | Tue 28 Dec 2021 | 331-1 v SouthamptonSouthampton 1-1 Tottenham Hotspur | Premier League |
| 22 | Sat 1 Jan 2022 | 331-0 v WatfordWatford 0-1 Tottenham Hotspur | Premier League |
| 23 | Wed 5 Jan 2022 | 330-2 v ChelseaChelsea 2-0 Tottenham Hotspur | Carabao Cup Semi Final |
| 24 | Sun 9 Jan 2022 | 333-1 v MorecambeTottenham Hotspur 3-1 Morecambe | Emirates FA Cup Third Round |
| 25 | Wed 12 Jan 2022 | 330-1 v ChelseaTottenham Hotspur 0-1 Chelsea | Carabao Cup Semi Final |
| 26 | Wed 19 Jan 2022 | 333-2 v Leicester CityLeicester City 2-3 Tottenham Hotspur | Premier League |
| 27 | Sun 23 Jan 2022 | 330-2 v ChelseaChelsea 2-0 Tottenham Hotspur | Premier League |
| 28 | Sat 5 Feb 2022 | 333-1 v Brighton & Hove AlbionTottenham Hotspur 3-1 Brighton & Hove Albion | Emirates FA Cup Fourth Round |
| 29 | Wed 9 Feb 2022 | 332-3 v SouthamptonTottenham Hotspur 2-3 Southampton | Premier League |
| 30 | Sun 13 Feb 2022 | 330-2 v Wolverhampton WanderersTottenham Hotspur 0-2 Wolverhampton Wanderers | Premier League |
| 31 | Sat 19 Feb 2022 | 333-2 v Manchester CityManchester City 2-3 Tottenham Hotspur | Premier League |
| 32 | Wed 23 Feb 2022 | 330-1 v BurnleyBurnley 1-0 Tottenham Hotspur | Premier League |
| 33 | Sat 26 Feb 2022 | 33 4-0 v Leeds UnitedLeeds United 0-4 Tottenham Hotspur | Premier League |
| 34 | Tue 1 Mar 2022 | 330-1 v MiddlesbroughMiddlesbrough 1-0 Tottenham Hotspur | Emirates FA Cup Fifth Round |
| 35 | Mon 7 Mar 2022 | 335-0 v EvertonTottenham Hotspur 5-0 Everton | Premier League |
| 36 | Sat 12 Mar 2022 | 332-3 v Manchester UnitedManchester United 3-2 Tottenham Hotspur | Premier League |
| 37 | Wed 16 Mar 2022 | 332-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-2 Tottenham Hotspur | Premier League |
| 38 | Sun 20 Mar 2022 | 333-1 v West Ham UnitedTottenham Hotspur 3-1 West Ham United | Premier League |
| 39 | Thu 24 Mar 2022 | 42-1 v AustriaWales 2-1 Austria | World Cup Qualification (Europe) |
| 40 | Sun 3 Apr 2022 | 335-1 v Newcastle UnitedTottenham Hotspur 5-1 Newcastle United | Premier League |
| 41 | Sat 9 Apr 2022 | 334-0 v Aston VillaAston Villa 0-4 Tottenham Hotspur | Premier League |
| 42 | Sat 16 Apr 2022 | 330-1 v Brighton & Hove AlbionTottenham Hotspur 0-1 Brighton & Hove Albion | Premier League |
| 43 | Sat 23 Apr 2022 | 330-0 v BrentfordBrentford 0-0 Tottenham Hotspur | Premier League |
| 44 | Sun 1 May 2022 | 33 3-1 v Leicester CityTottenham Hotspur 3-1 Leicester City | Premier League |
| 45 | Sat 7 May 2022 | 33 1-1 v LiverpoolLiverpool 1-1 Tottenham Hotspur | Premier League |
| 46 | Thu 12 May 2022 | 33 3-0 v ArsenalTottenham Hotspur 3-0 Arsenal | Premier League |
| 47 | Sun 15 May 2022 | 331-0 v BurnleyTottenham Hotspur 1-0 Burnley | Premier League |
| 48 | Sun 22 May 2022 | 335-0 v Norwich CityNorwich City 0-5 Tottenham Hotspur | Premier League |
| 49 | Sun 5 Jun 2022 | 41-0 v UkraineWales 1-0 Ukraine | World Cup Qualification (Europe) |
| 50 | Wed 8 Jun 2022 | 41-2 v NetherlandsWales 1-2 Netherlands | UEFA Nations League League A Group 4 |
| 51 | Sat 11 Jun 2022 | 41-1 v BelgiumWales 1-1 Belgium | UEFA Nations League League A Group 4 |
| 52 | Tue 14 Jun 2022 | 42-3 v NetherlandsNetherlands 3-2 Wales | UEFA Nations League League A Group 4 |
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