| 1 | Sun 8 Aug 2021 | 71-1 v LorientSaint Étienne 1-1 Lorient | French Ligue 1 |
| 2 | Wed 22 Sep 2021 | 71-3 v MonacoMonaco 3-1 Saint Étienne | French Ligue 1 |
| 3 | Sat 25 Sep 2021 | 70-3 v NiceSaint Étienne 0-3 Nice | French Ligue 1 |
| 4 | Sun 3 Oct 2021 | 71-1 v LyonSaint Étienne 1-1 Lyon | French Ligue 1 |
| 5 | Sun 17 Oct 2021 | 71-5 v StrasbourgStrasbourg 5-1 Saint Étienne | French Ligue 1 |
| 6 | Fri 22 Oct 2021 | 72-2 v AngersSaint Étienne 2-2 Angers | French Ligue 1 |
| 7 | Sat 30 Oct 2021 | 71-1 v MetzMetz 1-1 Saint Étienne | French Ligue 1 |
| 8 | Sun 28 Nov 2021 | 7 1-3 v Paris St GermainSaint Étienne 1-3 Paris St Germain | French Ligue 1 |
| 9 | Wed 1 Dec 2021 | 70-1 v BrestBrest 1-0 Saint Étienne | French Ligue 1 |
| 10 | Sun 5 Dec 2021 | 70-5 v RennesSaint Étienne 0-5 Rennes | French Ligue 1 |
| 11 | Sat 11 Dec 2021 | 70-2 v ReimsReims 2-0 Saint Étienne | French Ligue 1 |
| 12 | Wed 22 Dec 2021 | 70-1 v NantesSaint Étienne 0-1 Nantes | French Ligue 1 |
| 13 | Sat 15 Jan 2022 | 71-2 v LensSaint Étienne 1-2 Lens | French Ligue 1 |
| 14 | Wed 26 Jan 2022 | 71-0 v AngersAngers 0-1 Saint Étienne | French Ligue 1 |
| 15 | Sat 5 Feb 2022 | 73-1 v MontpellierSaint Étienne 3-1 Montpellier | French Ligue 1 |
| 16 | Sun 13 Feb 2022 | 7 2-1 v ClermontClermont 1-2 Saint Étienne | French Ligue 1 |
| 17 | Sun 20 Feb 2022 | 72-2 v StrasbourgSaint Étienne 2-2 Strasbourg | French Ligue 1 |
| 18 | Sat 26 Feb 2022 | 71-3 v Paris St GermainParis St Germain 3-1 Saint Étienne | French Ligue 1 |
| 19 | Sun 6 Mar 2022 | 71-0 v MetzSaint Étienne 1-0 Metz | French Ligue 1 |
| 20 | Fri 11 Mar 2022 | 70-0 v LilleLille 0-0 Saint Étienne | French Ligue 1 |
| 21 | Fri 18 Mar 2022 | 71-1 v TroyesSaint Étienne 1-1 Troyes | French Ligue 1 |
| 22 | Sun 3 Apr 2022 | 72-4 v MarseilleSaint Étienne 2-4 Marseille | French Ligue 1 |
| 23 | Fri 8 Apr 2022 | 72-6 v LorientLorient 6-2 Saint Étienne | French Ligue 1 |
| 24 | Sat 16 Apr 2022 | 72-1 v BrestSaint Étienne 2-1 Brest | French Ligue 1 |
| 25 | Wed 20 Apr 2022 | 72-2 v BordeauxBordeaux 2-2 Saint Étienne | French Ligue 1 |
| 26 | Sat 23 Apr 2022 | 71-4 v MonacoSaint Étienne 1-4 Monaco | French Ligue 1 |
| 27 | Wed 11 May 2022 | 72-4 v NiceNice 4-2 Saint Étienne | French Ligue 1 |
| 28 | Sat 14 May 2022 | 71-2 v ReimsSaint Étienne 1-2 Reims | French Ligue 1 |
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