| 1 | Sun 15 Aug 2021 | 29 3-1 v Hertha Berlin1. FC Köln 3-1 Hertha Berlin | German Bundesliga |
| 2 | Sun 22 Aug 2021 | 292-3 v Bayern MunichBayern Munich 3-2 1. FC Köln | German Bundesliga |
| 3 | Sat 18 Sep 2021 | 291-1 v RB Leipzig1. FC Köln 1-1 RB Leipzig | German Bundesliga |
| 4 | Sat 25 Sep 2021 | 291-1 v Eintracht FrankfurtEintracht Frankfurt 1-1 1. FC Köln | German Bundesliga |
| 5 | Fri 15 Oct 2021 | 290-5 v 1899 Hoffenheim1899 Hoffenheim 5-0 1. FC Köln | German Bundesliga |
| 6 | Sun 24 Oct 2021 | 292-2 v Bayer 04 Leverkusen1. FC Köln 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 7 | Sat 30 Oct 2021 | 290-2 v Borussia DortmundBorussia Dortmund 2-0 1. FC Köln | German Bundesliga |
| 8 | Sun 7 Nov 2021 | 292-2 v 1. FC Union Berlin1. FC Köln 2-2 1. FC Union Berlin | German Bundesliga |
| 9 | Sun 21 Nov 2021 | 291-1 v Mainz 05Mainz 05 1-1 1. FC Köln | German Bundesliga |
| 10 | Sat 27 Nov 2021 | 294-1 v Borussia Mönchengladbach1. FC Köln 4-1 Borussia Mönchengladbach | German Bundesliga |
| 11 | Sat 4 Dec 2021 | 291-1 v Arminia BielefeldArminia Bielefeld 1-1 1. FC Köln | German Bundesliga |
| 12 | Fri 10 Dec 2021 | 290-2 v FC Augsburg1. FC Köln 0-2 FC Augsburg | German Bundesliga |
| 13 | Tue 14 Dec 2021 | 293-2 v VfL WolfsburgVfL Wolfsburg 2-3 1. FC Köln | German Bundesliga |
| 14 | Sun 19 Dec 2021 | 29 1-0 v VfB Stuttgart1. FC Köln 1-0 VfB Stuttgart | German Bundesliga |
| 15 | Sun 9 Jan 2022 | 293-1 v Hertha BerlinHertha Berlin 1-3 1. FC Köln | German Bundesliga |
| 16 | Sat 15 Jan 2022 | 290-4 v Bayern Munich1. FC Köln 0-4 Bayern Munich | German Bundesliga |
| 17 | Sat 22 Jan 2022 | 292-2 v VfL BochumVfL Bochum 2-2 1. FC Köln | German Bundesliga |
| 18 | Sat 5 Feb 2022 | 29 1-0 v SC Freiburg1. FC Köln 1-0 SC Freiburg | German Bundesliga |
| 19 | Fri 11 Feb 2022 | 29 1-3 v RB LeipzigRB Leipzig 3-1 1. FC Köln | German Bundesliga |
| 20 | Sat 19 Feb 2022 | 291-0 v Eintracht Frankfurt1. FC Köln 1-0 Eintracht Frankfurt | German Bundesliga |
| 21 | Sat 26 Feb 2022 | 291-1 v Greuther FürthGreuther Fürth 1-1 1. FC Köln | German Bundesliga |
| 22 | Sun 6 Mar 2022 | 290-1 v 1899 Hoffenheim1. FC Köln 0-1 1899 Hoffenheim | German Bundesliga |
| 23 | Sun 13 Mar 2022 | 291-0 v Bayer 04 LeverkusenBayer 04 Leverkusen 0-1 1. FC Köln | German Bundesliga |
| 24 | Sun 20 Mar 2022 | 291-1 v Borussia Dortmund1. FC Köln 1-1 Borussia Dortmund | German Bundesliga |
| 25 | Fri 1 Apr 2022 | 29 0-1 v 1. FC Union Berlin1. FC Union Berlin 1-0 1. FC Köln | German Bundesliga |
| 26 | Sat 16 Apr 2022 | 293-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-3 1. FC Köln | German Bundesliga |
| 27 | Sat 23 Apr 2022 | 293-1 v Arminia Bielefeld1. FC Köln 3-1 Arminia Bielefeld | German Bundesliga |
| 28 | Sat 30 Apr 2022 | 29 4-1 v FC AugsburgFC Augsburg 1-4 1. FC Köln | German Bundesliga |
| 29 | Sat 7 May 2022 | 290-1 v VfL Wolfsburg1. FC Köln 0-1 VfL Wolfsburg | German Bundesliga |
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