| 1 | Sat 14 Aug 2021 | 10-1 v VfL WolfsburgVfL Wolfsburg 1-0 VfL Bochum | German Bundesliga |
| 2 | Sat 21 Aug 2021 | 1 2-0 v Mainz 05VfL Bochum 2-0 Mainz 05 | German Bundesliga |
| 3 | Sat 28 Aug 2021 | 11-2 v 1. FC Köln1. FC Köln 2-1 VfL Bochum | German Bundesliga |
| 4 | Sun 12 Sep 2021 | 11-3 v Hertha BerlinVfL Bochum 1-3 Hertha Berlin | German Bundesliga |
| 5 | Sat 18 Sep 2021 | 10-7 v Bayern MunichBayern Munich 7-0 VfL Bochum | German Bundesliga |
| 6 | Sun 26 Sep 2021 | 10-0 v VfB StuttgartVfL Bochum 0-0 VfB Stuttgart | German Bundesliga |
| 7 | Sat 2 Oct 2021 | 10-3 v RB LeipzigRB Leipzig 3-0 VfL Bochum | German Bundesliga |
| 8 | Sat 16 Oct 2021 | 1 1-0 v Greuther FürthGreuther Fürth 0-1 VfL Bochum | German Bundesliga |
| 9 | Sun 24 Oct 2021 | 12-0 v Eintracht FrankfurtVfL Bochum 2-0 Eintracht Frankfurt | German Bundesliga |
| 10 | Sun 31 Oct 2021 | 11-2 v Borussia MönchengladbachBorussia Mönchengladbach 2-1 VfL Bochum | German Bundesliga |
| 11 | Sat 6 Nov 2021 | 12-0 v 1899 HoffenheimVfL Bochum 2-0 1899 Hoffenheim | German Bundesliga |
| 12 | Sat 20 Nov 2021 | 10-1 v Bayer 04 LeverkusenBayer 04 Leverkusen 1-0 VfL Bochum | German Bundesliga |
| 13 | Sat 27 Nov 2021 | 12-1 v SC FreiburgVfL Bochum 2-1 SC Freiburg | German Bundesliga |
| 14 | Sat 11 Dec 2021 | 11-1 v Borussia DortmundVfL Bochum 1-1 Borussia Dortmund | German Bundesliga |
| 15 | Tue 14 Dec 2021 | 10-2 v Arminia BielefeldArminia Bielefeld 2-0 VfL Bochum | German Bundesliga |
| 16 | Sat 18 Dec 2021 | 10-1 v 1. FC Union BerlinVfL Bochum 0-1 1. FC Union Berlin | German Bundesliga |
| 17 | Sun 9 Jan 2022 | 11-0 v VfL WolfsburgVfL Bochum 1-0 VfL Wolfsburg | German Bundesliga |
| 18 | Sat 15 Jan 2022 | 10-1 v Mainz 05Mainz 05 1-0 VfL Bochum | German Bundesliga |
| 19 | Sat 22 Jan 2022 | 12-2 v 1. FC KölnVfL Bochum 2-2 1. FC Köln | German Bundesliga |
| 20 | Fri 4 Feb 2022 | 11-1 v Hertha BerlinHertha Berlin 1-1 VfL Bochum | German Bundesliga |
| 21 | Sat 19 Feb 2022 | 11-1 v VfB StuttgartVfB Stuttgart 1-1 VfL Bochum | German Bundesliga |
| 22 | Sun 27 Feb 2022 | 10-1 v RB LeipzigVfL Bochum 0-1 RB Leipzig | German Bundesliga |
| 23 | Sat 5 Mar 2022 | 12-1 v Greuther FürthVfL Bochum 2-1 Greuther Fürth | German Bundesliga |
| 24 | Sun 13 Mar 2022 | 11-2 v Eintracht FrankfurtEintracht Frankfurt 2-1 VfL Bochum | German Bundesliga |
| 25 | Fri 18 Mar 2022 | 10-2 v Borussia MönchengladbachVfL Bochum 0-2 Borussia Mönchengladbach | German Bundesliga |
| 26 | Sat 2 Apr 2022 | 12-1 v 1899 Hoffenheim1899 Hoffenheim 1-2 VfL Bochum | German Bundesliga |
| 27 | Sun 10 Apr 2022 | 10-0 v Bayer 04 LeverkusenVfL Bochum 0-0 Bayer 04 Leverkusen | German Bundesliga |
| 28 | Sat 16 Apr 2022 | 10-3 v SC FreiburgSC Freiburg 3-0 VfL Bochum | German Bundesliga |
| 29 | Sun 24 Apr 2022 | 10-2 v FC AugsburgVfL Bochum 0-2 FC Augsburg | German Bundesliga |
| 30 | Sat 30 Apr 2022 | 14-3 v Borussia DortmundBorussia Dortmund 3-4 VfL Bochum | German Bundesliga |
| 31 | Fri 6 May 2022 | 12-1 v Arminia BielefeldVfL Bochum 2-1 Arminia Bielefeld | German Bundesliga |
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