| 1 | Sat 14 Aug 2021 | 254-0 v FC AugsburgFC Augsburg 0-4 1899 Hoffenheim | German Bundesliga |
| 2 | Sun 22 Aug 2021 | 252-2 v 1. FC Union Berlin1899 Hoffenheim 2-2 1. FC Union Berlin | German Bundesliga |
| 3 | Fri 27 Aug 2021 | 252-3 v Borussia DortmundBorussia Dortmund 3-2 1899 Hoffenheim | German Bundesliga |
| 4 | Sat 25 Sep 2021 | 253-1 v VfL Wolfsburg1899 Hoffenheim 3-1 VfL Wolfsburg | German Bundesliga |
| 5 | Sat 2 Oct 2021 | 251-3 v VfB StuttgartVfB Stuttgart 3-1 1899 Hoffenheim | German Bundesliga |
| 6 | Fri 15 Oct 2021 | 255-0 v 1. FC Köln1899 Hoffenheim 5-0 1. FC Köln | German Bundesliga |
| 7 | Sat 23 Oct 2021 | 250-4 v Bayern MunichBayern Munich 4-0 1899 Hoffenheim | German Bundesliga |
| 8 | Fri 29 Oct 2021 | 25 2-0 v Hertha Berlin1899 Hoffenheim 2-0 Hertha Berlin | German Bundesliga |
| 9 | Sat 6 Nov 2021 | 250-2 v VfL BochumVfL Bochum 2-0 1899 Hoffenheim | German Bundesliga |
| 10 | Sat 20 Nov 2021 | 252-0 v RB Leipzig1899 Hoffenheim 2-0 RB Leipzig | German Bundesliga |
| 11 | Sat 27 Nov 2021 | 256-3 v Greuther FürthGreuther Fürth 3-6 1899 Hoffenheim | German Bundesliga |
| 12 | Sat 4 Dec 2021 | 253-2 v Eintracht Frankfurt1899 Hoffenheim 3-2 Eintracht Frankfurt | German Bundesliga |
| 13 | Sat 11 Dec 2021 | 25 2-1 v SC FreiburgSC Freiburg 1-2 1899 Hoffenheim | German Bundesliga |
| 14 | Wed 15 Dec 2021 | 252-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-2 1899 Hoffenheim | German Bundesliga |
| 15 | Sat 18 Dec 2021 | 251-1 v Borussia Mönchengladbach1899 Hoffenheim 1-1 Borussia Mönchengladbach | German Bundesliga |
| 16 | Sat 8 Jan 2022 | 253-1 v FC Augsburg1899 Hoffenheim 3-1 FC Augsburg | German Bundesliga |
| 17 | Sat 15 Jan 2022 | 25 1-2 v 1. FC Union Berlin1. FC Union Berlin 2-1 1899 Hoffenheim | German Bundesliga |
| 18 | Sat 19 Feb 2022 | 252-1 v VfL WolfsburgVfL Wolfsburg 1-2 1899 Hoffenheim | German Bundesliga |
| 19 | Sun 6 Mar 2022 | 251-0 v 1. FC Köln1. FC Köln 0-1 1899 Hoffenheim | German Bundesliga |
| 20 | Sat 12 Mar 2022 | 251-1 v Bayern Munich1899 Hoffenheim 1-1 Bayern Munich | German Bundesliga |
| 21 | Sat 19 Mar 2022 | 25 0-3 v Hertha BerlinHertha Berlin 3-0 1899 Hoffenheim | German Bundesliga |
| 22 | Sat 2 Apr 2022 | 25 1-2 v VfL Bochum1899 Hoffenheim 1-2 VfL Bochum | German Bundesliga |
| 23 | Sun 17 Apr 2022 | 250-0 v Greuther Fürth1899 Hoffenheim 0-0 Greuther Fürth | German Bundesliga |
| 24 | Sat 23 Apr 2022 | 252-2 v Eintracht FrankfurtEintracht Frankfurt 2-2 1899 Hoffenheim | German Bundesliga |
| 25 | Sat 30 Apr 2022 | 253-4 v SC Freiburg1899 Hoffenheim 3-4 SC Freiburg | German Bundesliga |
| 26 | Sat 14 May 2022 | 251-5 v Borussia MönchengladbachBorussia Mönchengladbach 5-1 1899 Hoffenheim | German Bundesliga |
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