| 1 | Sat 11 Sep 2021 | 30-2 v Mainz 051899 Hoffenheim 0-2 Mainz 05 | German Bundesliga |
| 2 | Sat 18 Sep 2021 | 30-0 v Arminia BielefeldArminia Bielefeld 0-0 1899 Hoffenheim | German Bundesliga |
| 3 | Sat 25 Sep 2021 | 3 3-1 v VfL Wolfsburg1899 Hoffenheim 3-1 VfL Wolfsburg | German Bundesliga |
| 4 | Sat 2 Oct 2021 | 31-3 v VfB StuttgartVfB Stuttgart 3-1 1899 Hoffenheim | German Bundesliga |
| 5 | Fri 15 Oct 2021 | 3 5-0 v 1. FC Köln1899 Hoffenheim 5-0 1. FC Köln | German Bundesliga |
| 6 | Sat 11 Dec 2021 | 32-1 v SC FreiburgSC Freiburg 1-2 1899 Hoffenheim | German Bundesliga |
| 7 | Wed 15 Dec 2021 | 32-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-2 1899 Hoffenheim | German Bundesliga |
| 8 | Sat 18 Dec 2021 | 3 1-1 v Borussia Mönchengladbach1899 Hoffenheim 1-1 Borussia Mönchengladbach | German Bundesliga |
| 9 | Sat 8 Jan 2022 | 33-1 v FC Augsburg1899 Hoffenheim 3-1 FC Augsburg | German Bundesliga |
| 10 | Sun 13 Feb 2022 | 32-0 v Arminia Bielefeld1899 Hoffenheim 2-0 Arminia Bielefeld | German Bundesliga |
| 11 | Sat 19 Feb 2022 | 32-1 v VfL WolfsburgVfL Wolfsburg 1-2 1899 Hoffenheim | German Bundesliga |
| 12 | Fri 25 Feb 2022 | 32-1 v VfB Stuttgart1899 Hoffenheim 2-1 VfB Stuttgart | German Bundesliga |
| 13 | Sun 6 Mar 2022 | 31-0 v 1. FC Köln1. FC Köln 0-1 1899 Hoffenheim | German Bundesliga |
| 14 | Sat 12 Mar 2022 | 31-1 v Bayern Munich1899 Hoffenheim 1-1 Bayern Munich | German Bundesliga |
| 15 | Sat 2 Apr 2022 | 31-2 v VfL Bochum1899 Hoffenheim 1-2 VfL Bochum | German Bundesliga |
| 16 | Sun 10 Apr 2022 | 3 0-3 v RB LeipzigRB Leipzig 3-0 1899 Hoffenheim | German Bundesliga |
| 17 | Sun 17 Apr 2022 | 3 0-0 v Greuther Fürth1899 Hoffenheim 0-0 Greuther Fürth | German Bundesliga |
| 18 | Sat 30 Apr 2022 | 33-4 v SC Freiburg1899 Hoffenheim 3-4 SC Freiburg | German Bundesliga |
| 19 | Sat 7 May 2022 | 32-4 v Bayer 04 Leverkusen1899 Hoffenheim 2-4 Bayer 04 Leverkusen | German Bundesliga |
Football Web Pages