| 1 | Sat 14 Aug 2021 | 104-0 v FC AugsburgFC Augsburg 0-4 1899 Hoffenheim | German Bundesliga |
| 2 | Sun 22 Aug 2021 | 102-2 v 1. FC Union Berlin1899 Hoffenheim 2-2 1. FC Union Berlin | German Bundesliga |
| 3 | Fri 27 Aug 2021 | 102-3 v Borussia DortmundBorussia Dortmund 3-2 1899 Hoffenheim | German Bundesliga |
| 4 | Sat 11 Sep 2021 | 100-2 v Mainz 051899 Hoffenheim 0-2 Mainz 05 | German Bundesliga |
| 5 | Sat 2 Oct 2021 | 101-3 v VfB StuttgartVfB Stuttgart 3-1 1899 Hoffenheim | German Bundesliga |
| 6 | Sat 9 Oct 2021 | 102-3 v ScotlandScotland 3-2 Israel | World Cup Qualification (Europe) |
| 7 | Tue 12 Oct 2021 | 102-1 v MoldovaIsrael 2-1 Moldova | World Cup Qualification (Europe) |
| 8 | Sat 6 Nov 2021 | 100-2 v VfL BochumVfL Bochum 2-0 1899 Hoffenheim | German Bundesliga |
| 9 | Fri 12 Nov 2021 | 102-4 v AustriaAustria 4-2 Israel | World Cup Qualification (Europe) |
| 10 | Mon 15 Nov 2021 | 10 3-2 v Faroe IslandsIsrael 3-2 Faroe Islands | World Cup Qualification (Europe) |
| 11 | Sat 20 Nov 2021 | 102-0 v RB Leipzig1899 Hoffenheim 2-0 RB Leipzig | German Bundesliga |
| 12 | Sat 27 Nov 2021 | 106-3 v Greuther FürthGreuther Fürth 3-6 1899 Hoffenheim | German Bundesliga |
| 13 | Sat 4 Dec 2021 | 103-2 v Eintracht Frankfurt1899 Hoffenheim 3-2 Eintracht Frankfurt | German Bundesliga |
| 14 | Sat 11 Dec 2021 | 102-1 v SC FreiburgSC Freiburg 1-2 1899 Hoffenheim | German Bundesliga |
| 15 | Wed 15 Dec 2021 | 10 2-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-2 1899 Hoffenheim | German Bundesliga |
| 16 | Sat 18 Dec 2021 | 101-1 v Borussia Mönchengladbach1899 Hoffenheim 1-1 Borussia Mönchengladbach | German Bundesliga |
| 17 | Sat 8 Jan 2022 | 103-1 v FC Augsburg1899 Hoffenheim 3-1 FC Augsburg | German Bundesliga |
| 18 | Sat 15 Jan 2022 | 10 1-2 v 1. FC Union Berlin1. FC Union Berlin 2-1 1899 Hoffenheim | German Bundesliga |
| 19 | Sat 22 Jan 2022 | 10 2-3 v Borussia Dortmund1899 Hoffenheim 2-3 Borussia Dortmund | German Bundesliga |
| 20 | Sat 5 Feb 2022 | 100-2 v Mainz 05Mainz 05 2-0 1899 Hoffenheim | German Bundesliga |
| 21 | Sun 13 Feb 2022 | 102-0 v Arminia Bielefeld1899 Hoffenheim 2-0 Arminia Bielefeld | German Bundesliga |
| 22 | Sat 19 Feb 2022 | 102-1 v VfL WolfsburgVfL Wolfsburg 1-2 1899 Hoffenheim | German Bundesliga |
| 23 | Fri 25 Feb 2022 | 102-1 v VfB Stuttgart1899 Hoffenheim 2-1 VfB Stuttgart | German Bundesliga |
| 24 | Sun 6 Mar 2022 | 10 1-0 v 1. FC Köln1. FC Köln 0-1 1899 Hoffenheim | German Bundesliga |
| 25 | Sat 12 Mar 2022 | 101-1 v Bayern Munich1899 Hoffenheim 1-1 Bayern Munich | German Bundesliga |
| 26 | Sat 19 Mar 2022 | 100-3 v Hertha BerlinHertha Berlin 3-0 1899 Hoffenheim | German Bundesliga |
| 27 | Sun 10 Apr 2022 | 100-3 v RB LeipzigRB Leipzig 3-0 1899 Hoffenheim | German Bundesliga |
| 28 | Sun 17 Apr 2022 | 100-0 v Greuther Fürth1899 Hoffenheim 0-0 Greuther Fürth | German Bundesliga |
| 29 | Sat 23 Apr 2022 | 102-2 v Eintracht FrankfurtEintracht Frankfurt 2-2 1899 Hoffenheim | German Bundesliga |
| 30 | Sat 30 Apr 2022 | 103-4 v SC Freiburg1899 Hoffenheim 3-4 SC Freiburg | German Bundesliga |
| 31 | Sat 7 May 2022 | 10 2-4 v Bayer 04 Leverkusen1899 Hoffenheim 2-4 Bayer 04 Leverkusen | German Bundesliga |
| 32 | Thu 2 Jun 2022 | 102-2 v IcelandIsrael 2-2 Iceland | UEFA Nations League League B Group 2 |
| 33 | Fri 10 Jun 2022 | 102-1 v AlbaniaAlbania 1-2 Israel | UEFA Nations League League B Group 2 |
| 34 | Mon 13 Jun 2022 | 102-2 v IcelandIceland 2-2 Israel | UEFA Nations League League B Group 2 |
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