| 1 | Sat 28 Aug 2021 | 224-1 v FC AugsburgFC Augsburg 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 2 | Thu 16 Sep 2021 | 222-1 v Ferencvárosi TCBayer 04 Leverkusen 2-1 Ferencvárosi TC | UEFA Europa League Group G |
| 3 | Sun 3 Oct 2021 | 224-0 v Arminia BielefeldArminia Bielefeld 0-4 Bayer 04 Leverkusen | German Bundesliga |
| 4 | Sat 30 Oct 2021 | 220-2 v VfL WolfsburgBayer 04 Leverkusen 0-2 VfL Wolfsburg | German Bundesliga |
| 5 | Thu 4 Nov 2021 | 224-0 v Real BetisBayer 04 Leverkusen 4-0 Real Betis | UEFA Europa League Group G |
| 6 | Sun 7 Nov 2021 | 221-1 v Hertha BerlinHertha Berlin 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 7 | Sat 20 Nov 2021 | 221-0 v VfL BochumBayer 04 Leverkusen 1-0 VfL Bochum | German Bundesliga |
| 8 | Thu 25 Nov 2021 | 223-2 v CelticBayer 04 Leverkusen 3-2 Celtic | UEFA Europa League Group G |
| 9 | Thu 9 Dec 2021 | 220-1 v Ferencvárosi TCFerencvárosi TC 1-0 Bayer 04 Leverkusen | UEFA Europa League Group G |
| 10 | Sun 19 Dec 2021 | 221-2 v SC FreiburgSC Freiburg 2-1 Bayer 04 Leverkusen | German Bundesliga |
| 11 | Sun 20 Mar 2022 | 222-0 v VfL WolfsburgVfL Wolfsburg 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 12 | Sun 10 Apr 2022 | 220-0 v VfL BochumVfL Bochum 0-0 Bayer 04 Leverkusen | German Bundesliga |
| 13 | Sat 23 Apr 2022 | 224-1 v Greuther FürthGreuther Fürth 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 14 | Mon 2 May 2022 | 222-0 v Eintracht FrankfurtBayer 04 Leverkusen 2-0 Eintracht Frankfurt | German Bundesliga |
| 15 | Sat 7 May 2022 | 224-2 v 1899 Hoffenheim1899 Hoffenheim 2-4 Bayer 04 Leverkusen | German Bundesliga |
| 16 | Sat 14 May 2022 | 222-1 v SC FreiburgBayer 04 Leverkusen 2-1 SC Freiburg | German Bundesliga |
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