| 1 | Sat 14 Aug 2021 | 41-5 v VfB StuttgartVfB Stuttgart 5-1 Greuther Fürth | German Bundesliga |
| 2 | Sat 21 Aug 2021 | 4 1-1 v Arminia BielefeldGreuther Fürth 1-1 Arminia Bielefeld | German Bundesliga |
| 3 | Sat 28 Aug 2021 | 40-3 v Mainz 05Mainz 05 3-0 Greuther Fürth | German Bundesliga |
| 4 | Sat 11 Sep 2021 | 40-2 v VfL WolfsburgGreuther Fürth 0-2 VfL Wolfsburg | German Bundesliga |
| 5 | Fri 17 Sep 2021 | 41-2 v Hertha BerlinHertha Berlin 2-1 Greuther Fürth | German Bundesliga |
| 6 | Fri 24 Sep 2021 | 41-3 v Bayern MunichGreuther Fürth 1-3 Bayern Munich | German Bundesliga |
| 7 | Fri 1 Oct 2021 | 41-3 v 1. FC Köln1. FC Köln 3-1 Greuther Fürth | German Bundesliga |
| 8 | Sat 23 Oct 2021 | 41-4 v RB LeipzigRB Leipzig 4-1 Greuther Fürth | German Bundesliga |
| 9 | Sat 20 Nov 2021 | 40-4 v Borussia MönchengladbachBorussia Mönchengladbach 4-0 Greuther Fürth | German Bundesliga |
| 10 | Sat 27 Nov 2021 | 43-6 v 1899 HoffenheimGreuther Fürth 3-6 1899 Hoffenheim | German Bundesliga |
| 11 | Sat 4 Dec 2021 | 41-7 v Bayer 04 LeverkusenBayer 04 Leverkusen 7-1 Greuther Fürth | German Bundesliga |
| 12 | Sun 12 Dec 2021 | 4 1-0 v 1. FC Union BerlinGreuther Fürth 1-0 1. FC Union Berlin | German Bundesliga |
| 13 | Wed 15 Dec 2021 | 4 0-3 v Borussia DortmundBorussia Dortmund 3-0 Greuther Fürth | German Bundesliga |
| 14 | Sat 18 Dec 2021 | 40-0 v FC AugsburgGreuther Fürth 0-0 FC Augsburg | German Bundesliga |
| 15 | Sat 8 Jan 2022 | 40-0 v VfB StuttgartGreuther Fürth 0-0 VfB Stuttgart | German Bundesliga |
| 16 | Sun 16 Jan 2022 | 42-2 v Arminia BielefeldArminia Bielefeld 2-2 Greuther Fürth | German Bundesliga |
| 17 | Sat 22 Jan 2022 | 42-1 v Mainz 05Greuther Fürth 2-1 Mainz 05 | German Bundesliga |
| 18 | Sat 12 Feb 2022 | 42-1 v Hertha BerlinGreuther Fürth 2-1 Hertha Berlin | German Bundesliga |
| 19 | Sun 20 Feb 2022 | 4 1-4 v Bayern MunichBayern Munich 4-1 Greuther Fürth | German Bundesliga |
| 20 | Sun 13 Mar 2022 | 41-6 v RB LeipzigGreuther Fürth 1-6 RB Leipzig | German Bundesliga |
| 21 | Sat 19 Mar 2022 | 40-0 v SC FreiburgGreuther Fürth 0-0 SC Freiburg | German Bundesliga |
| 22 | Sat 2 Apr 2022 | 40-0 v Eintracht FrankfurtEintracht Frankfurt 0-0 Greuther Fürth | German Bundesliga |
| 23 | Sat 9 Apr 2022 | 40-2 v Borussia MönchengladbachGreuther Fürth 0-2 Borussia Mönchengladbach | German Bundesliga |
| 24 | Sun 17 Apr 2022 | 4 0-0 v 1899 Hoffenheim1899 Hoffenheim 0-0 Greuther Fürth | German Bundesliga |
| 25 | Fri 29 Apr 2022 | 41-1 v 1. FC Union Berlin1. FC Union Berlin 1-1 Greuther Fürth | German Bundesliga |
| 26 | Sat 7 May 2022 | 41-3 v Borussia DortmundGreuther Fürth 1-3 Borussia Dortmund | German Bundesliga |
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