| 1 | Sat 21 Aug 2021 | 41-2 v VfL WolfsburgHertha Berlin 1-2 VfL Wolfsburg | German Bundesliga |
| 2 | Sat 28 Aug 2021 | 40-5 v Bayern MunichBayern Munich 5-0 Hertha Berlin | German Bundesliga |
| 3 | Wed 8 Sep 2021 | 41-0 v BelarusBelarus 0-1 Belgium | World Cup Qualification (Europe) |
| 4 | Sun 12 Sep 2021 | 43-1 v VfL BochumVfL Bochum 1-3 Hertha Berlin | German Bundesliga |
| 5 | Fri 17 Sep 2021 | 42-1 v Greuther FürthHertha Berlin 2-1 Greuther Fürth | German Bundesliga |
| 6 | Sat 2 Oct 2021 | 41-2 v SC FreiburgHertha Berlin 1-2 SC Freiburg | German Bundesliga |
| 7 | Sat 16 Oct 2021 | 42-1 v Eintracht FrankfurtEintracht Frankfurt 1-2 Hertha Berlin | German Bundesliga |
| 8 | Sat 23 Oct 2021 | 41-0 v Borussia MönchengladbachHertha Berlin 1-0 Borussia Mönchengladbach | German Bundesliga |
| 9 | Fri 29 Oct 2021 | 4 0-2 v 1899 Hoffenheim1899 Hoffenheim 2-0 Hertha Berlin | German Bundesliga |
| 10 | Tue 16 Nov 2021 | 41-1 v WalesWales 1-1 Belgium | World Cup Qualification (Europe) |
| 11 | Sun 5 Dec 2021 | 42-2 v VfB StuttgartVfB Stuttgart 2-2 Hertha Berlin | German Bundesliga |
| 12 | Sat 11 Dec 2021 | 42-0 v Arminia BielefeldHertha Berlin 2-0 Arminia Bielefeld | German Bundesliga |
| 13 | Tue 14 Dec 2021 | 40-4 v Mainz 05Mainz 05 4-0 Hertha Berlin | German Bundesliga |
| 14 | Sat 15 Jan 2022 | 40-0 v VfL WolfsburgVfL Wolfsburg 0-0 Hertha Berlin | German Bundesliga |
| 15 | Sun 23 Jan 2022 | 41-4 v Bayern MunichHertha Berlin 1-4 Bayern Munich | German Bundesliga |
| 16 | Sat 26 Feb 2022 | 40-3 v SC FreiburgSC Freiburg 3-0 Hertha Berlin | German Bundesliga |
| 17 | Sat 5 Mar 2022 | 41-4 v Eintracht FrankfurtHertha Berlin 1-4 Eintracht Frankfurt | German Bundesliga |
| 18 | Sat 19 Mar 2022 | 43-0 v 1899 HoffenheimHertha Berlin 3-0 1899 Hoffenheim | German Bundesliga |
| 19 | Sat 2 Apr 2022 | 41-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-1 Hertha Berlin | German Bundesliga |
| 20 | Sat 9 Apr 2022 | 41-4 v 1. FC Union BerlinHertha Berlin 1-4 1. FC Union Berlin | German Bundesliga |
| 21 | Sat 16 Apr 2022 | 4 1-0 v FC AugsburgFC Augsburg 0-1 Hertha Berlin | German Bundesliga |
| 22 | Sun 24 Apr 2022 | 42-0 v VfB StuttgartHertha Berlin 2-0 VfB Stuttgart | German Bundesliga |
| 23 | Sat 30 Apr 2022 | 41-1 v Arminia BielefeldArminia Bielefeld 1-1 Hertha Berlin | German Bundesliga |
| 24 | Sat 7 May 2022 | 41-2 v Mainz 05Hertha Berlin 1-2 Mainz 05 | German Bundesliga |
| 25 | Sat 14 May 2022 | 41-2 v Borussia DortmundBorussia Dortmund 2-1 Hertha Berlin | German Bundesliga |
| 26 | Fri 3 Jun 2022 | 41-4 v NetherlandsBelgium 1-4 Netherlands | UEFA Nations League League A Group 4 |
| 27 | Sat 11 Jun 2022 | 41-1 v WalesWales 1-1 Belgium | UEFA Nations League League A Group 4 |
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