| 1 | Sat 14 Aug 2021 | 14-0 v FC AugsburgFC Augsburg 0-4 1899 Hoffenheim | German Bundesliga |
| 2 | Sun 22 Aug 2021 | 12-2 v 1. FC Union Berlin1899 Hoffenheim 2-2 1. FC Union Berlin | German Bundesliga |
| 3 | Fri 27 Aug 2021 | 12-3 v Borussia DortmundBorussia Dortmund 3-2 1899 Hoffenheim | German Bundesliga |
| 4 | Sat 11 Sep 2021 | 10-2 v Mainz 051899 Hoffenheim 0-2 Mainz 05 | German Bundesliga |
| 5 | Sat 18 Sep 2021 | 10-0 v Arminia BielefeldArminia Bielefeld 0-0 1899 Hoffenheim | German Bundesliga |
| 6 | Sat 25 Sep 2021 | 13-1 v VfL Wolfsburg1899 Hoffenheim 3-1 VfL Wolfsburg | German Bundesliga |
| 7 | Sat 2 Oct 2021 | 11-3 v VfB StuttgartVfB Stuttgart 3-1 1899 Hoffenheim | German Bundesliga |
| 8 | Fri 15 Oct 2021 | 15-0 v 1. FC Köln1899 Hoffenheim 5-0 1. FC Köln | German Bundesliga |
| 9 | Sat 23 Oct 2021 | 10-4 v Bayern MunichBayern Munich 4-0 1899 Hoffenheim | German Bundesliga |
| 10 | Fri 29 Oct 2021 | 12-0 v Hertha Berlin1899 Hoffenheim 2-0 Hertha Berlin | German Bundesliga |
| 11 | Sat 6 Nov 2021 | 10-2 v VfL BochumVfL Bochum 2-0 1899 Hoffenheim | German Bundesliga |
| 12 | Sat 20 Nov 2021 | 12-0 v RB Leipzig1899 Hoffenheim 2-0 RB Leipzig | German Bundesliga |
| 13 | Sat 4 Dec 2021 | 13-2 v Eintracht Frankfurt1899 Hoffenheim 3-2 Eintracht Frankfurt | German Bundesliga |
| 14 | Sat 11 Dec 2021 | 12-1 v SC FreiburgSC Freiburg 1-2 1899 Hoffenheim | German Bundesliga |
| 15 | Wed 15 Dec 2021 | 12-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-2 1899 Hoffenheim | German Bundesliga |
| 16 | Sat 18 Dec 2021 | 11-1 v Borussia Mönchengladbach1899 Hoffenheim 1-1 Borussia Mönchengladbach | German Bundesliga |
| 17 | Sat 8 Jan 2022 | 13-1 v FC Augsburg1899 Hoffenheim 3-1 FC Augsburg | German Bundesliga |
| 18 | Sat 15 Jan 2022 | 11-2 v 1. FC Union Berlin1. FC Union Berlin 2-1 1899 Hoffenheim | German Bundesliga |
| 19 | Sat 22 Jan 2022 | 12-3 v Borussia Dortmund1899 Hoffenheim 2-3 Borussia Dortmund | German Bundesliga |
| 20 | Sat 5 Feb 2022 | 10-2 v Mainz 05Mainz 05 2-0 1899 Hoffenheim | German Bundesliga |
| 21 | Sun 13 Feb 2022 | 12-0 v Arminia Bielefeld1899 Hoffenheim 2-0 Arminia Bielefeld | German Bundesliga |
| 22 | Sat 19 Feb 2022 | 12-1 v VfL WolfsburgVfL Wolfsburg 1-2 1899 Hoffenheim | German Bundesliga |
| 23 | Fri 25 Feb 2022 | 12-1 v VfB Stuttgart1899 Hoffenheim 2-1 VfB Stuttgart | German Bundesliga |
| 24 | Sun 6 Mar 2022 | 1 1-0 v 1. FC Köln1. FC Köln 0-1 1899 Hoffenheim | German Bundesliga |
| 25 | Sat 12 Mar 2022 | 11-1 v Bayern Munich1899 Hoffenheim 1-1 Bayern Munich | German Bundesliga |
| 26 | Sat 19 Mar 2022 | 10-3 v Hertha BerlinHertha Berlin 3-0 1899 Hoffenheim | German Bundesliga |
| 27 | Sat 2 Apr 2022 | 11-2 v VfL Bochum1899 Hoffenheim 1-2 VfL Bochum | German Bundesliga |
| 28 | Sun 10 Apr 2022 | 10-3 v RB LeipzigRB Leipzig 3-0 1899 Hoffenheim | German Bundesliga |
| 29 | Sun 17 Apr 2022 | 10-0 v Greuther Fürth1899 Hoffenheim 0-0 Greuther Fürth | German Bundesliga |
| 30 | Sat 23 Apr 2022 | 12-2 v Eintracht FrankfurtEintracht Frankfurt 2-2 1899 Hoffenheim | German Bundesliga |
| 31 | Sat 30 Apr 2022 | 13-4 v SC Freiburg1899 Hoffenheim 3-4 SC Freiburg | German Bundesliga |
| 32 | Sat 7 May 2022 | 12-4 v Bayer 04 Leverkusen1899 Hoffenheim 2-4 Bayer 04 Leverkusen | German Bundesliga |
| 33 | Sat 14 May 2022 | 11-5 v Borussia MönchengladbachBorussia Mönchengladbach 5-1 1899 Hoffenheim | German Bundesliga |
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