| 1 | Sat 14 Aug 2021 | 260-0 v Arminia BielefeldArminia Bielefeld 0-0 SC Freiburg | German Bundesliga |
| 2 | Sat 21 Aug 2021 | 262-1 v Borussia DortmundSC Freiburg 2-1 Borussia Dortmund | German Bundesliga |
| 3 | Sat 28 Aug 2021 | 263-2 v VfB StuttgartVfB Stuttgart 2-3 SC Freiburg | German Bundesliga |
| 4 | Sat 11 Sep 2021 | 261-1 v 1. FC KölnSC Freiburg 1-1 1. FC Köln | German Bundesliga |
| 5 | Sat 18 Sep 2021 | 260-0 v Mainz 05Mainz 05 0-0 SC Freiburg | German Bundesliga |
| 6 | Sun 26 Sep 2021 | 263-0 v FC AugsburgSC Freiburg 3-0 FC Augsburg | German Bundesliga |
| 7 | Sat 2 Oct 2021 | 262-1 v Hertha BerlinHertha Berlin 1-2 SC Freiburg | German Bundesliga |
| 8 | Sat 16 Oct 2021 | 261-1 v RB LeipzigSC Freiburg 1-1 RB Leipzig | German Bundesliga |
| 9 | Sat 23 Oct 2021 | 262-0 v VfL WolfsburgVfL Wolfsburg 0-2 SC Freiburg | German Bundesliga |
| 10 | Sat 30 Oct 2021 | 263-1 v Greuther FürthSC Freiburg 3-1 Greuther Fürth | German Bundesliga |
| 11 | Sat 6 Nov 2021 | 261-2 v Bayern MunichBayern Munich 2-1 SC Freiburg | German Bundesliga |
| 12 | Sun 21 Nov 2021 | 260-2 v Eintracht FrankfurtSC Freiburg 0-2 Eintracht Frankfurt | German Bundesliga |
| 13 | Sat 27 Nov 2021 | 261-2 v VfL BochumVfL Bochum 2-1 SC Freiburg | German Bundesliga |
| 14 | Sun 5 Dec 2021 | 266-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-6 SC Freiburg | German Bundesliga |
| 15 | Sat 11 Dec 2021 | 261-2 v 1899 HoffenheimSC Freiburg 1-2 1899 Hoffenheim | German Bundesliga |
| 16 | Wed 15 Dec 2021 | 260-0 v 1. FC Union Berlin1. FC Union Berlin 0-0 SC Freiburg | German Bundesliga |
| 17 | Sun 19 Dec 2021 | 262-1 v Bayer 04 LeverkusenSC Freiburg 2-1 Bayer 04 Leverkusen | German Bundesliga |
| 18 | Sat 22 Jan 2022 | 262-0 v VfB StuttgartSC Freiburg 2-0 VfB Stuttgart | German Bundesliga |
| 19 | Sat 5 Feb 2022 | 260-1 v 1. FC Köln1. FC Köln 1-0 SC Freiburg | German Bundesliga |
| 20 | Sat 12 Feb 2022 | 261-1 v Mainz 05SC Freiburg 1-1 Mainz 05 | German Bundesliga |
| 21 | Sat 19 Feb 2022 | 262-1 v FC AugsburgFC Augsburg 1-2 SC Freiburg | German Bundesliga |
| 22 | Sat 26 Feb 2022 | 263-0 v Hertha BerlinSC Freiburg 3-0 Hertha Berlin | German Bundesliga |
| 23 | Sat 5 Mar 2022 | 261-1 v RB LeipzigRB Leipzig 1-1 SC Freiburg | German Bundesliga |
| 24 | Sat 12 Mar 2022 | 263-2 v VfL WolfsburgSC Freiburg 3-2 VfL Wolfsburg | German Bundesliga |
| 25 | Sat 19 Mar 2022 | 260-0 v Greuther FürthGreuther Fürth 0-0 SC Freiburg | German Bundesliga |
| 26 | Tue 29 Mar 2022 | 11-1 v GermanyNetherlands 1-1 Germany | International Friendly |
| 27 | Sat 2 Apr 2022 | 261-4 v Bayern MunichSC Freiburg 1-4 Bayern Munich | German Bundesliga |
| 28 | Sun 10 Apr 2022 | 262-1 v Eintracht FrankfurtEintracht Frankfurt 1-2 SC Freiburg | German Bundesliga |
| 29 | Sat 16 Apr 2022 | 263-0 v VfL BochumSC Freiburg 3-0 VfL Bochum | German Bundesliga |
| 30 | Sat 23 Apr 2022 | 263-3 v Borussia MönchengladbachSC Freiburg 3-3 Borussia Mönchengladbach | German Bundesliga |
| 31 | Sat 30 Apr 2022 | 264-3 v 1899 Hoffenheim1899 Hoffenheim 3-4 SC Freiburg | German Bundesliga |
| 32 | Sat 7 May 2022 | 261-4 v 1. FC Union BerlinSC Freiburg 1-4 1. FC Union Berlin | German Bundesliga |
| 33 | Sat 14 May 2022 | 261-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-1 SC Freiburg | German Bundesliga |
| 34 | Wed 8 Jun 2022 | 132-1 v WalesWales 1-2 Netherlands | UEFA Nations League League A Group 4 |
| 35 | Sat 11 Jun 2022 | 132-2 v PolandNetherlands 2-2 Poland | UEFA Nations League League A Group 4 |
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