| 1 | Sat 14 Aug 2021 | 30-4 v 1899 HoffenheimFC Augsburg 0-4 1899 Hoffenheim | German Bundesliga |
| 2 | Sat 21 Aug 2021 | 30-0 v Eintracht FrankfurtEintracht Frankfurt 0-0 FC Augsburg | German Bundesliga |
| 3 | Sat 28 Aug 2021 | 31-4 v Bayer 04 LeverkusenFC Augsburg 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 4 | Sat 11 Sep 2021 | 30-0 v 1. FC Union Berlin1. FC Union Berlin 0-0 FC Augsburg | German Bundesliga |
| 5 | Sat 18 Sep 2021 | 31-0 v Borussia MönchengladbachFC Augsburg 1-0 Borussia Mönchengladbach | German Bundesliga |
| 6 | Sun 26 Sep 2021 | 30-3 v SC FreiburgSC Freiburg 3-0 FC Augsburg | German Bundesliga |
| 7 | Sat 2 Oct 2021 | 31-2 v Borussia DortmundBorussia Dortmund 2-1 FC Augsburg | German Bundesliga |
| 8 | Sun 17 Oct 2021 | 31-1 v Arminia BielefeldFC Augsburg 1-1 Arminia Bielefeld | German Bundesliga |
| 9 | Fri 22 Oct 2021 | 31-4 v Mainz 05Mainz 05 4-1 FC Augsburg | German Bundesliga |
| 10 | Sun 31 Oct 2021 | 34-1 v VfB StuttgartFC Augsburg 4-1 VfB Stuttgart | German Bundesliga |
| 11 | Sat 6 Nov 2021 | 3 0-1 v VfL WolfsburgVfL Wolfsburg 1-0 FC Augsburg | German Bundesliga |
| 12 | Fri 19 Nov 2021 | 32-1 v Bayern MunichFC Augsburg 2-1 Bayern Munich | German Bundesliga |
| 13 | Sat 27 Nov 2021 | 31-1 v Hertha BerlinHertha Berlin 1-1 FC Augsburg | German Bundesliga |
| 14 | Fri 10 Dec 2021 | 32-0 v 1. FC Köln1. FC Köln 0-2 FC Augsburg | German Bundesliga |
| 15 | Wed 15 Dec 2021 | 31-1 v RB LeipzigFC Augsburg 1-1 RB Leipzig | German Bundesliga |
| 16 | Sat 18 Dec 2021 | 30-0 v Greuther FürthGreuther Fürth 0-0 FC Augsburg | German Bundesliga |
| 17 | Sun 16 Jan 2022 | 31-1 v Eintracht FrankfurtFC Augsburg 1-1 Eintracht Frankfurt | German Bundesliga |
| 18 | Sat 22 Jan 2022 | 3 1-5 v Bayer 04 LeverkusenBayer 04 Leverkusen 5-1 FC Augsburg | German Bundesliga |
| 19 | Sat 5 Feb 2022 | 32-0 v 1. FC Union BerlinFC Augsburg 2-0 1. FC Union Berlin | German Bundesliga |
| 20 | Sat 12 Feb 2022 | 32-3 v Borussia MönchengladbachBorussia Mönchengladbach 3-2 FC Augsburg | German Bundesliga |
| 21 | Sun 27 Feb 2022 | 31-1 v Borussia DortmundFC Augsburg 1-1 Borussia Dortmund | German Bundesliga |
| 22 | Fri 4 Mar 2022 | 3 1-0 v Arminia BielefeldArminia Bielefeld 0-1 FC Augsburg | German Bundesliga |
| 23 | Sat 19 Mar 2022 | 3 2-3 v VfB StuttgartVfB Stuttgart 3-2 FC Augsburg | German Bundesliga |
| 24 | Sun 3 Apr 2022 | 33-0 v VfL WolfsburgFC Augsburg 3-0 VfL Wolfsburg | German Bundesliga |
| 25 | Wed 6 Apr 2022 | 32-1 v Mainz 05FC Augsburg 2-1 Mainz 05 | German Bundesliga |
| 26 | Sat 16 Apr 2022 | 30-1 v Hertha BerlinFC Augsburg 0-1 Hertha Berlin | German Bundesliga |
| 27 | Sun 24 Apr 2022 | 3 2-0 v VfL BochumVfL Bochum 0-2 FC Augsburg | German Bundesliga |
| 28 | Sun 8 May 2022 | 30-4 v RB LeipzigRB Leipzig 4-0 FC Augsburg | German Bundesliga |
| 29 | Sat 14 May 2022 | 32-1 v Greuther FürthFC Augsburg 2-1 Greuther Fürth | German Bundesliga |
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