| 1 | Sat 11 Sep 2021 | 344-3 v Bayer 04 LeverkusenBayer 04 Leverkusen 3-4 Borussia Dortmund | German Bundesliga |
| 2 | Wed 15 Sep 2021 | 342-1 v BeşiktaşBeşiktaş 1-2 Borussia Dortmund | UEFA Champions League Group C |
| 3 | Sun 19 Sep 2021 | 344-2 v 1. FC Union BerlinBorussia Dortmund 4-2 1. FC Union Berlin | German Bundesliga |
| 4 | Sat 25 Sep 2021 | 34 0-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-0 Borussia Dortmund | German Bundesliga |
| 5 | Sat 2 Oct 2021 | 342-1 v FC AugsburgBorussia Dortmund 2-1 FC Augsburg | German Bundesliga |
| 6 | Sat 16 Oct 2021 | 343-1 v Mainz 05Borussia Dortmund 3-1 Mainz 05 | German Bundesliga |
| 7 | Tue 19 Oct 2021 | 340-4 v AjaxAjax 4-0 Borussia Dortmund | UEFA Champions League Group C |
| 8 | Sat 23 Oct 2021 | 343-1 v Arminia BielefeldArminia Bielefeld 1-3 Borussia Dortmund | German Bundesliga |
| 9 | Sat 30 Oct 2021 | 342-0 v 1. FC KölnBorussia Dortmund 2-0 1. FC Köln | German Bundesliga |
| 10 | Wed 3 Nov 2021 | 341-3 v AjaxBorussia Dortmund 1-3 Ajax | UEFA Champions League Group C |
| 11 | Sat 6 Nov 2021 | 341-2 v RB LeipzigRB Leipzig 2-1 Borussia Dortmund | German Bundesliga |
| 12 | Wed 24 Nov 2021 | 341-3 v Sporting LisbonSporting Lisbon 3-1 Borussia Dortmund | UEFA Champions League Group C |
| 13 | Tue 7 Dec 2021 | 345-0 v BeşiktaşBorussia Dortmund 5-0 Beşiktaş | UEFA Champions League Group C |
| 14 | Sat 18 Dec 2021 | 34 2-3 v Hertha BerlinHertha Berlin 3-2 Borussia Dortmund | German Bundesliga |
| 15 | Sat 22 Jan 2022 | 343-2 v 1899 Hoffenheim1899 Hoffenheim 2-3 Borussia Dortmund | German Bundesliga |
| 16 | Sun 20 Feb 2022 | 346-0 v Borussia MönchengladbachBorussia Dortmund 6-0 Borussia Mönchengladbach | German Bundesliga |
| 17 | Sun 27 Feb 2022 | 341-1 v FC AugsburgFC Augsburg 1-1 Borussia Dortmund | German Bundesliga |
| 18 | Sun 13 Mar 2022 | 341-0 v Arminia BielefeldBorussia Dortmund 1-0 Arminia Bielefeld | German Bundesliga |
| 19 | Wed 16 Mar 2022 | 34 1-0 v Mainz 05Mainz 05 0-1 Borussia Dortmund | German Bundesliga |
| 20 | Sun 20 Mar 2022 | 341-1 v 1. FC Köln1. FC Köln 1-1 Borussia Dortmund | German Bundesliga |
| 21 | Tue 29 Mar 2022 | 6 2-1 v BulgariaCroatia 2-1 Bulgaria | International Friendly |
| 22 | Sat 16 Apr 2022 | 346-1 v VfL WolfsburgBorussia Dortmund 6-1 VfL Wolfsburg | German Bundesliga |
| 23 | Sat 14 May 2022 | 342-1 v Hertha BerlinBorussia Dortmund 2-1 Hertha Berlin | German Bundesliga |
| 24 | Fri 3 Jun 2022 | 60-3 v AustriaCroatia 0-3 Austria | UEFA Nations League League A Group 1 |
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