| 1 | Sat 6 Nov 2021 | 51-2 v RB LeipzigRB Leipzig 2-1 Borussia Dortmund | German Bundesliga |
| 2 | Wed 24 Nov 2021 | 5 1-3 v Sporting LisbonSporting Lisbon 3-1 Borussia Dortmund | UEFA Champions League Group C |
| 3 | Sat 27 Nov 2021 | 53-1 v VfL WolfsburgVfL Wolfsburg 1-3 Borussia Dortmund | German Bundesliga |
| 4 | Tue 7 Dec 2021 | 55-0 v BeşiktaşBorussia Dortmund 5-0 Beşiktaş | UEFA Champions League Group C |
| 5 | Sat 11 Dec 2021 | 5 1-1 v VfL BochumVfL Bochum 1-1 Borussia Dortmund | German Bundesliga |
| 6 | Wed 15 Dec 2021 | 53-0 v Greuther FürthBorussia Dortmund 3-0 Greuther Fürth | German Bundesliga |
| 7 | Sat 18 Dec 2021 | 52-3 v Hertha BerlinHertha Berlin 3-2 Borussia Dortmund | German Bundesliga |
| 8 | Sat 22 Jan 2022 | 53-2 v 1899 Hoffenheim1899 Hoffenheim 2-3 Borussia Dortmund | German Bundesliga |
| 9 | Sun 6 Feb 2022 | 52-5 v Bayer 04 LeverkusenBorussia Dortmund 2-5 Bayer 04 Leverkusen | German Bundesliga |
| 10 | Sun 13 Feb 2022 | 53-0 v 1. FC Union Berlin1. FC Union Berlin 0-3 Borussia Dortmund | German Bundesliga |
| 11 | Thu 17 Feb 2022 | 5 2-4 v RangersBorussia Dortmund 2-4 Rangers | UEFA Europa League Round of 32 |
| 12 | Sun 20 Feb 2022 | 5 6-0 v Borussia MönchengladbachBorussia Dortmund 6-0 Borussia Mönchengladbach | German Bundesliga |
| 13 | Fri 8 Apr 2022 | 52-0 v VfB StuttgartVfB Stuttgart 0-2 Borussia Dortmund | German Bundesliga |
| 14 | Sat 16 Apr 2022 | 56-1 v VfL WolfsburgBorussia Dortmund 6-1 VfL Wolfsburg | German Bundesliga |
| 15 | Sat 23 Apr 2022 | 51-3 v Bayern MunichBayern Munich 3-1 Borussia Dortmund | German Bundesliga |
| 16 | Sat 30 Apr 2022 | 53-4 v VfL BochumBorussia Dortmund 3-4 VfL Bochum | German Bundesliga |
| 17 | Sat 7 May 2022 | 53-1 v Greuther FürthGreuther Fürth 1-3 Borussia Dortmund | German Bundesliga |
| 18 | Sat 14 May 2022 | 52-1 v Hertha BerlinBorussia Dortmund 2-1 Hertha Berlin | German Bundesliga |
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