| 1 | Sun 15 Aug 2021 | 51-3 v 1. FC Köln1. FC Köln 3-1 Hertha Berlin | German Bundesliga |
| 2 | Sat 21 Aug 2021 | 51-2 v VfL WolfsburgHertha Berlin 1-2 VfL Wolfsburg | German Bundesliga |
| 3 | Sat 28 Aug 2021 | 50-5 v Bayern MunichBayern Munich 5-0 Hertha Berlin | German Bundesliga |
| 4 | Sun 12 Sep 2021 | 53-1 v VfL BochumVfL Bochum 1-3 Hertha Berlin | German Bundesliga |
| 5 | Fri 17 Sep 2021 | 52-1 v Greuther FürthHertha Berlin 2-1 Greuther Fürth | German Bundesliga |
| 6 | Sat 25 Sep 2021 | 5 0-6 v RB LeipzigRB Leipzig 6-0 Hertha Berlin | German Bundesliga |
| 7 | Sat 2 Oct 2021 | 51-2 v SC FreiburgHertha Berlin 1-2 SC Freiburg | German Bundesliga |
| 8 | Sat 16 Oct 2021 | 52-1 v Eintracht FrankfurtEintracht Frankfurt 1-2 Hertha Berlin | German Bundesliga |
| 9 | Fri 29 Oct 2021 | 50-2 v 1899 Hoffenheim1899 Hoffenheim 2-0 Hertha Berlin | German Bundesliga |
| 10 | Sun 7 Nov 2021 | 51-1 v Bayer 04 LeverkusenHertha Berlin 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 11 | Sat 20 Nov 2021 | 50-2 v 1. FC Union Berlin1. FC Union Berlin 2-0 Hertha Berlin | German Bundesliga |
| 12 | Sat 27 Nov 2021 | 51-1 v FC AugsburgHertha Berlin 1-1 FC Augsburg | German Bundesliga |
| 13 | Sun 5 Dec 2021 | 52-2 v VfB StuttgartVfB Stuttgart 2-2 Hertha Berlin | German Bundesliga |
| 14 | Sat 11 Dec 2021 | 52-0 v Arminia BielefeldHertha Berlin 2-0 Arminia Bielefeld | German Bundesliga |
| 15 | Tue 14 Dec 2021 | 5 0-4 v Mainz 05Mainz 05 4-0 Hertha Berlin | German Bundesliga |
| 16 | Sat 18 Dec 2021 | 53-2 v Borussia DortmundHertha Berlin 3-2 Borussia Dortmund | German Bundesliga |
| 17 | Sun 9 Jan 2022 | 51-3 v 1. FC KölnHertha Berlin 1-3 1. FC Köln | German Bundesliga |
| 18 | Sat 15 Jan 2022 | 50-0 v VfL WolfsburgVfL Wolfsburg 0-0 Hertha Berlin | German Bundesliga |
| 19 | Fri 4 Feb 2022 | 51-1 v VfL BochumHertha Berlin 1-1 VfL Bochum | German Bundesliga |
| 20 | Sat 12 Feb 2022 | 5 1-2 v Greuther FürthGreuther Fürth 2-1 Hertha Berlin | German Bundesliga |
| 21 | Sat 12 Mar 2022 | 50-2 v Borussia MönchengladbachBorussia Mönchengladbach 2-0 Hertha Berlin | German Bundesliga |
| 22 | Sat 19 Mar 2022 | 53-0 v 1899 HoffenheimHertha Berlin 3-0 1899 Hoffenheim | German Bundesliga |
| 23 | Sat 2 Apr 2022 | 51-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-1 Hertha Berlin | German Bundesliga |
| 24 | Sat 16 Apr 2022 | 51-0 v FC AugsburgFC Augsburg 0-1 Hertha Berlin | German Bundesliga |
| 25 | Sun 24 Apr 2022 | 52-0 v VfB StuttgartHertha Berlin 2-0 VfB Stuttgart | German Bundesliga |
| 26 | Sat 30 Apr 2022 | 51-1 v Arminia BielefeldArminia Bielefeld 1-1 Hertha Berlin | German Bundesliga |
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