1 | Sat 21 Aug 2021 | 31 0-2 v VfL BochumVfL Bochum 2-0 Mainz 05 | German Bundesliga |
2 | Sat 28 Aug 2021 | 31 3-0 v Greuther FürthMainz 05 3-0 Greuther Fürth | German Bundesliga |
3 | Sat 11 Sep 2021 | 312-0 v 1899 Hoffenheim1899 Hoffenheim 0-2 Mainz 05 | German Bundesliga |
4 | Sat 18 Sep 2021 | 310-0 v SC FreiburgMainz 05 0-0 SC Freiburg | German Bundesliga |
5 | Sat 25 Sep 2021 | 310-1 v Bayer 04 LeverkusenBayer 04 Leverkusen 1-0 Mainz 05 | German Bundesliga |
6 | Sun 3 Oct 2021 | 31 1-2 v 1. FC Union BerlinMainz 05 1-2 1. FC Union Berlin | German Bundesliga |
7 | Fri 22 Oct 2021 | 314-1 v FC AugsburgMainz 05 4-1 FC Augsburg | German Bundesliga |
8 | Sat 30 Oct 2021 | 31 2-1 v Arminia BielefeldArminia Bielefeld 1-2 Mainz 05 | German Bundesliga |
9 | Fri 5 Nov 2021 | 311-1 v Borussia MönchengladbachMainz 05 1-1 Borussia Mönchengladbach | German Bundesliga |
10 | Sun 21 Nov 2021 | 311-1 v 1. FC KölnMainz 05 1-1 1. FC Köln | German Bundesliga |
11 | Sat 5 Feb 2022 | 312-0 v 1899 HoffenheimMainz 05 2-0 1899 Hoffenheim | German Bundesliga |
12 | Sat 12 Feb 2022 | 31 1-1 v SC FreiburgSC Freiburg 1-1 Mainz 05 | German Bundesliga |
13 | Fri 18 Feb 2022 | 313-2 v Bayer 04 LeverkusenMainz 05 3-2 Bayer 04 Leverkusen | German Bundesliga |
14 | Sat 26 Feb 2022 | 31 1-3 v 1. FC Union Berlin1. FC Union Berlin 3-1 Mainz 05 | German Bundesliga |
15 | Sat 19 Mar 2022 | 31 4-0 v Arminia BielefeldMainz 05 4-0 Arminia Bielefeld | German Bundesliga |
16 | Wed 6 Apr 2022 | 311-2 v FC AugsburgFC Augsburg 2-1 Mainz 05 | German Bundesliga |
17 | Sat 9 Apr 2022 | 312-3 v 1. FC Köln1. FC Köln 3-2 Mainz 05 | German Bundesliga |
18 | Sat 16 Apr 2022 | 310-0 v VfB StuttgartMainz 05 0-0 VfB Stuttgart | German Bundesliga |
19 | Fri 22 Apr 2022 | 31 0-5 v VfL WolfsburgVfL Wolfsburg 5-0 Mainz 05 | German Bundesliga |
20 | Sat 30 Apr 2022 | 313-1 v Bayern MunichMainz 05 3-1 Bayern Munich | German Bundesliga |
21 | Sat 7 May 2022 | 312-1 v Hertha BerlinHertha Berlin 1-2 Mainz 05 | German Bundesliga |
22 | Sat 14 May 2022 | 312-2 v Eintracht FrankfurtMainz 05 2-2 Eintracht Frankfurt | German Bundesliga |