| 1 | Sat 28 Aug 2021 | 233-0 v Greuther FürthMainz 05 3-0 Greuther Fürth | German Bundesliga |
| 2 | Sat 11 Sep 2021 | 23 2-0 v 1899 Hoffenheim1899 Hoffenheim 0-2 Mainz 05 | German Bundesliga |
| 3 | Sat 18 Sep 2021 | 230-0 v SC FreiburgMainz 05 0-0 SC Freiburg | German Bundesliga |
| 4 | Sat 25 Sep 2021 | 23 0-1 v Bayer 04 LeverkusenBayer 04 Leverkusen 1-0 Mainz 05 | German Bundesliga |
| 5 | Sun 3 Oct 2021 | 231-2 v 1. FC Union BerlinMainz 05 1-2 1. FC Union Berlin | German Bundesliga |
| 6 | Sat 16 Oct 2021 | 231-3 v Borussia DortmundBorussia Dortmund 3-1 Mainz 05 | German Bundesliga |
| 7 | Sat 30 Oct 2021 | 232-1 v Arminia BielefeldArminia Bielefeld 1-2 Mainz 05 | German Bundesliga |
| 8 | Sat 8 Jan 2022 | 231-4 v RB LeipzigRB Leipzig 4-1 Mainz 05 | German Bundesliga |
| 9 | Sat 15 Jan 2022 | 231-0 v VfL BochumMainz 05 1-0 VfL Bochum | German Bundesliga |
| 10 | Wed 16 Mar 2022 | 23 0-1 v Borussia DortmundMainz 05 0-1 Borussia Dortmund | German Bundesliga |
| 11 | Sat 19 Mar 2022 | 234-0 v Arminia BielefeldMainz 05 4-0 Arminia Bielefeld | German Bundesliga |
| 12 | Sat 16 Apr 2022 | 230-0 v VfB StuttgartMainz 05 0-0 VfB Stuttgart | German Bundesliga |
| 13 | Fri 22 Apr 2022 | 230-5 v VfL WolfsburgVfL Wolfsburg 5-0 Mainz 05 | German Bundesliga |
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