| 1 | Sat 14 Aug 2021 | 5 0-0 v Arminia BielefeldArminia Bielefeld 0-0 SC Freiburg | German Bundesliga |
| 2 | Sat 28 Aug 2021 | 53-2 v VfB StuttgartVfB Stuttgart 2-3 SC Freiburg | German Bundesliga |
| 3 | Sat 18 Sep 2021 | 50-0 v Mainz 05Mainz 05 0-0 SC Freiburg | German Bundesliga |
| 4 | Sun 26 Sep 2021 | 53-0 v FC AugsburgSC Freiburg 3-0 FC Augsburg | German Bundesliga |
| 5 | Sat 2 Oct 2021 | 52-1 v Hertha BerlinHertha Berlin 1-2 SC Freiburg | German Bundesliga |
| 6 | Sat 16 Oct 2021 | 51-1 v RB LeipzigSC Freiburg 1-1 RB Leipzig | German Bundesliga |
| 7 | Sat 23 Oct 2021 | 52-0 v VfL WolfsburgVfL Wolfsburg 0-2 SC Freiburg | German Bundesliga |
| 8 | Sat 6 Nov 2021 | 51-2 v Bayern MunichBayern Munich 2-1 SC Freiburg | German Bundesliga |
| 9 | Sun 21 Nov 2021 | 50-2 v Eintracht FrankfurtSC Freiburg 0-2 Eintracht Frankfurt | German Bundesliga |
| 10 | Sun 5 Dec 2021 | 56-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-6 SC Freiburg | German Bundesliga |
| 11 | Sat 11 Dec 2021 | 51-2 v 1899 HoffenheimSC Freiburg 1-2 1899 Hoffenheim | German Bundesliga |
| 12 | Sat 8 Jan 2022 | 5 2-2 v Arminia BielefeldSC Freiburg 2-2 Arminia Bielefeld | German Bundesliga |
| 13 | Fri 14 Jan 2022 | 51-5 v Borussia DortmundBorussia Dortmund 5-1 SC Freiburg | German Bundesliga |
| 14 | Sat 22 Jan 2022 | 52-0 v VfB StuttgartSC Freiburg 2-0 VfB Stuttgart | German Bundesliga |
| 15 | Sat 19 Feb 2022 | 52-1 v FC AugsburgFC Augsburg 1-2 SC Freiburg | German Bundesliga |
| 16 | Sat 5 Mar 2022 | 51-1 v RB LeipzigRB Leipzig 1-1 SC Freiburg | German Bundesliga |
| 17 | Sat 12 Mar 2022 | 53-2 v VfL WolfsburgSC Freiburg 3-2 VfL Wolfsburg | German Bundesliga |
| 18 | Sat 19 Mar 2022 | 50-0 v Greuther FürthGreuther Fürth 0-0 SC Freiburg | German Bundesliga |
| 19 | Sat 2 Apr 2022 | 51-4 v Bayern MunichSC Freiburg 1-4 Bayern Munich | German Bundesliga |
| 20 | Sat 30 Apr 2022 | 54-3 v 1899 Hoffenheim1899 Hoffenheim 3-4 SC Freiburg | German Bundesliga |
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