| 1 | Sat 14 Aug 2021 | 20-1 v VfL WolfsburgVfL Wolfsburg 1-0 VfL Bochum | German Bundesliga |
| 2 | Sat 21 Aug 2021 | 22-0 v Mainz 05VfL Bochum 2-0 Mainz 05 | German Bundesliga |
| 3 | Sat 16 Oct 2021 | 21-0 v Greuther FürthGreuther Fürth 0-1 VfL Bochum | German Bundesliga |
| 4 | Sun 24 Oct 2021 | 22-0 v Eintracht FrankfurtVfL Bochum 2-0 Eintracht Frankfurt | German Bundesliga |
| 5 | Sun 31 Oct 2021 | 21-2 v Borussia MönchengladbachBorussia Mönchengladbach 2-1 VfL Bochum | German Bundesliga |
| 6 | Sat 6 Nov 2021 | 22-0 v 1899 HoffenheimVfL Bochum 2-0 1899 Hoffenheim | German Bundesliga |
| 7 | Sat 11 Dec 2021 | 21-1 v Borussia DortmundVfL Bochum 1-1 Borussia Dortmund | German Bundesliga |
| 8 | Tue 14 Dec 2021 | 20-2 v Arminia BielefeldArminia Bielefeld 2-0 VfL Bochum | German Bundesliga |
| 9 | Sun 9 Jan 2022 | 21-0 v VfL WolfsburgVfL Bochum 1-0 VfL Wolfsburg | German Bundesliga |
| 10 | Sat 15 Jan 2022 | 2 0-1 v Mainz 05Mainz 05 1-0 VfL Bochum | German Bundesliga |
| 11 | Sat 22 Jan 2022 | 22-2 v 1. FC KölnVfL Bochum 2-2 1. FC Köln | German Bundesliga |
| 12 | Fri 4 Feb 2022 | 21-1 v Hertha BerlinHertha Berlin 1-1 VfL Bochum | German Bundesliga |
| 13 | Sat 12 Feb 2022 | 2 4-2 v Bayern MunichVfL Bochum 4-2 Bayern Munich | German Bundesliga |
| 14 | Sat 19 Feb 2022 | 2 1-1 v VfB StuttgartVfB Stuttgart 1-1 VfL Bochum | German Bundesliga |
| 15 | Sun 27 Feb 2022 | 2 0-1 v RB LeipzigVfL Bochum 0-1 RB Leipzig | German Bundesliga |
| 16 | Sat 5 Mar 2022 | 2 2-1 v Greuther FürthVfL Bochum 2-1 Greuther Fürth | German Bundesliga |
| 17 | Sat 2 Apr 2022 | 22-1 v 1899 Hoffenheim1899 Hoffenheim 1-2 VfL Bochum | German Bundesliga |
| 18 | Sun 10 Apr 2022 | 20-0 v Bayer 04 LeverkusenVfL Bochum 0-0 Bayer 04 Leverkusen | German Bundesliga |
| 19 | Sat 16 Apr 2022 | 20-3 v SC FreiburgSC Freiburg 3-0 VfL Bochum | German Bundesliga |
| 20 | Sun 24 Apr 2022 | 2 0-2 v FC AugsburgVfL Bochum 0-2 FC Augsburg | German Bundesliga |
| 21 | Sat 30 Apr 2022 | 24-3 v Borussia DortmundBorussia Dortmund 3-4 VfL Bochum | German Bundesliga |
| 22 | Fri 6 May 2022 | 22-1 v Arminia BielefeldVfL Bochum 2-1 Arminia Bielefeld | German Bundesliga |
| 23 | Sat 14 May 2022 | 22-3 v 1. FC Union Berlin1. FC Union Berlin 3-2 VfL Bochum | German Bundesliga |
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