| 1 | Sat 7 Aug 2021 | 211-1 v Cambridge UnitedCambridge United 1-1 Oxford United | Sky Bet League One |
| 2 | Sat 14 Aug 2021 | 212-1 v Charlton AthleticOxford United 2-1 Charlton Athletic | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 211-0 v Crewe AlexandraOxford United 1-0 Crewe Alexandra | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 211-2 v Bolton WanderersBolton Wanderers 2-1 Oxford United | Sky Bet League One |
| 5 | Tue 24 Aug 2021 | 210-2 v Queens Park RangersQueens Park Rangers 2-0 Oxford United | Carabao Cup Second Round |
| 6 | Sat 28 Aug 2021 | 213-1 v Lincoln CityOxford United 3-1 Lincoln City | Sky Bet League One |
| 7 | Sun 5 Sep 2021 | 181-0 v EstoniaEstonia 0-1 Northern Ireland | International Friendly |
| 8 | Sat 11 Sep 2021 | 210-0 v Wycombe WanderersOxford United 0-0 Wycombe Wanderers | Sky Bet League One |
| 9 | Sat 18 Sep 2021 | 210-1 v Cheltenham TownCheltenham Town 1-0 Oxford United | Sky Bet League One |
| 10 | Sat 25 Sep 2021 | 211-1 v GillinghamOxford United 1-1 Gillingham | Sky Bet League One |
| 11 | Sat 16 Oct 2021 | 211-3 v Plymouth ArgyleOxford United 1-3 Plymouth Argyle | Sky Bet League One |
| 12 | Tue 19 Oct 2021 | 212-0 v Shrewsbury TownOxford United 2-0 Shrewsbury Town | Sky Bet League One |
| 13 | Sat 23 Oct 2021 | 213-1 v Burton AlbionBurton Albion 1-3 Oxford United | Sky Bet League One |
| 14 | Sat 30 Oct 2021 | 213-1 v MorecambeOxford United 3-1 Morecambe | Sky Bet League One |
| 15 | Sun 7 Nov 2021 | 212-2 v Bristol RoversOxford United 2-2 Bristol Rovers | Emirates FA Cup First Round |
| 16 | Mon 15 Nov 2021 | 180-0 v ItalyNorthern Ireland 0-0 Italy | World Cup Qualification (Europe) |
| 17 | Tue 23 Nov 2021 | 21 3-1 v Fleetwood TownOxford United 3-1 Fleetwood Town | Sky Bet League One |
| 18 | Sat 27 Nov 2021 | 210-0 v Rotherham UnitedOxford United 0-0 Rotherham United | Sky Bet League One |
| 19 | Sat 4 Dec 2021 | 211-1 v SunderlandSunderland 1-1 Oxford United | Sky Bet League One |
| 20 | Tue 7 Dec 2021 | 212-1 v Doncaster RoversDoncaster Rovers 1-2 Oxford United | Sky Bet League One |
| 21 | Sat 11 Dec 2021 | 212-1 v Milton Keynes DonsMilton Keynes Dons 1-2 Oxford United | Sky Bet League One |
| 22 | Sat 18 Dec 2021 | 212-3 v Wigan AthleticOxford United 2-3 Wigan Athletic | Sky Bet League One |
| 23 | Wed 29 Dec 2021 | 213-0 v AFC WimbledonOxford United 3-0 AFC Wimbledon | Sky Bet League One |
| 24 | Sat 1 Jan 2022 | 211-1 v Cheltenham TownOxford United 1-1 Cheltenham Town | Sky Bet League One |
| 25 | Sat 8 Jan 2022 | 210-2 v Lincoln CityLincoln City 2-0 Oxford United | Sky Bet League One |
| 26 | Sat 15 Jan 2022 | 210-2 v Wycombe WanderersWycombe Wanderers 2-0 Oxford United | Sky Bet League One |
| 27 | Sat 12 Feb 2022 | 212-3 v Bolton WanderersOxford United 2-3 Bolton Wanderers | Sky Bet League One |
| 28 | Sat 19 Feb 2022 | 214-0 v Charlton AthleticCharlton Athletic 0-4 Oxford United | Sky Bet League One |
| 29 | Tue 22 Feb 2022 | 211-0 v Crewe AlexandraCrewe Alexandra 0-1 Oxford United | Sky Bet League One |
| 30 | Sat 26 Feb 2022 | 21 4-2 v Cambridge UnitedOxford United 4-2 Cambridge United | Sky Bet League One |
| 31 | Tue 1 Mar 2022 | 212-3 v PortsmouthPortsmouth 3-2 Oxford United | Sky Bet League One |
| 32 | Sat 5 Mar 2022 | 214-1 v Burton AlbionOxford United 4-1 Burton Albion | Sky Bet League One |
| 33 | Sat 12 Mar 2022 | 212-1 v Shrewsbury TownShrewsbury Town 1-2 Oxford United | Sky Bet League One |
| 34 | Sat 19 Mar 2022 | 211-1 v Ipswich TownOxford United 1-1 Ipswich Town | Sky Bet League One |
| 35 | Tue 29 Mar 2022 | 180-1 v HungaryNorthern Ireland 0-1 Hungary | International Friendly |
| 36 | Sat 2 Apr 2022 | 210-1 v Plymouth ArgylePlymouth Argyle 1-0 Oxford United | Sky Bet League One |
| 37 | Tue 5 Apr 2022 | 211-2 v MorecambeMorecambe 2-1 Oxford United | Sky Bet League One |
| 38 | Sat 9 Apr 2022 | 211-2 v SunderlandOxford United 1-2 Sunderland | Sky Bet League One |
| 39 | Fri 15 Apr 2022 | 213-2 v Fleetwood TownFleetwood Town 2-3 Oxford United | Sky Bet League One |
| 40 | Tue 19 Apr 2022 | 211-0 v Milton Keynes DonsOxford United 1-0 Milton Keynes Dons | Sky Bet League One |
| 41 | Sat 23 Apr 2022 | 211-2 v Rotherham UnitedRotherham United 2-1 Oxford United | Sky Bet League One |
| 42 | Sat 30 Apr 2022 | 211-1 v Doncaster RoversOxford United 1-1 Doncaster Rovers | Sky Bet League One |
| 43 | Thu 2 Jun 2022 | 18 0-1 v GreeceNorthern Ireland 0-1 Greece | UEFA Nations League League C Group 2 |
| 44 | Sun 5 Jun 2022 | 180-0 v CyprusCyprus 0-0 Northern Ireland | UEFA Nations League League C Group 2 |
| 45 | Thu 9 Jun 2022 | 182-3 v KosovoKosovo 3-2 Northern Ireland | UEFA Nations League League C Group 2 |
| 46 | Sun 12 Jun 2022 | 182-2 v CyprusNorthern Ireland 2-2 Cyprus | UEFA Nations League League C Group 2 |
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