| 1 | Tue 10 Aug 2021 | 31-0 v Charlton AthleticCharlton Athletic 0-1 AFC Wimbledon | Carabao Cup First Round |
| 2 | Tue 17 Aug 2021 | 31-1 v GillinghamAFC Wimbledon 1-1 Gillingham | Sky Bet League One |
| 3 | Tue 24 Aug 2021 | 3 1-0 v Northampton TownNorthampton Town 0-1 AFC Wimbledon | Carabao Cup Second Round |
| 4 | Sat 18 Sep 2021 | 30-1 v Plymouth ArgyleAFC Wimbledon 0-1 Plymouth Argyle | Sky Bet League One |
| 5 | Tue 28 Sep 2021 | 30-3 v Rotherham UnitedRotherham United 3-0 AFC Wimbledon | Sky Bet League One |
| 6 | Sat 30 Oct 2021 | 30-1 v Cambridge UnitedCambridge United 1-0 AFC Wimbledon | Sky Bet League One |
| 7 | Sat 6 Nov 2021 | 3 1-0 v GuiseleyAFC Wimbledon 1-0 Guiseley | Emirates FA Cup First Round |
| 8 | Sat 20 Nov 2021 | 31-2 v PortsmouthPortsmouth 2-1 AFC Wimbledon | Sky Bet League One |
| 9 | Tue 23 Nov 2021 | 33-2 v Crewe AlexandraAFC Wimbledon 3-2 Crewe Alexandra | Sky Bet League One |
| 10 | Sat 27 Nov 2021 | 32-2 v Fleetwood TownAFC Wimbledon 2-2 Fleetwood Town | Sky Bet League One |
| 11 | Sat 4 Dec 2021 | 34-3 v Cheltenham TownAFC Wimbledon 4-3 Cheltenham Town | Emirates FA Cup Second Round |
| 12 | Tue 7 Dec 2021 | 32-0 v Accrington StanleyAccrington Stanley 0-2 AFC Wimbledon | Sky Bet League One |
| 13 | Wed 29 Dec 2021 | 3 0-3 v Oxford UnitedOxford United 3-0 AFC Wimbledon | Sky Bet League One |
| 14 | Tue 18 Jan 2022 | 30-0 v PortsmouthAFC Wimbledon 0-0 Portsmouth | Sky Bet League One |
| 15 | Tue 25 Jan 2022 | 30-2 v Ipswich TownAFC Wimbledon 0-2 Ipswich Town | Sky Bet League One |
| 16 | Tue 8 Feb 2022 | 30-1 v Rotherham UnitedAFC Wimbledon 0-1 Rotherham United | Sky Bet League One |
| 17 | Sat 5 Mar 2022 | 30-1 v Wigan AthleticWigan Athletic 1-0 AFC Wimbledon | Sky Bet League One |
| 18 | Tue 8 Mar 2022 | 30-2 v Plymouth ArgylePlymouth Argyle 2-0 AFC Wimbledon | Sky Bet League One |
| 19 | Sat 2 Apr 2022 | 3 1-2 v Sheffield WednesdaySheffield Wednesday 2-1 AFC Wimbledon | Sky Bet League One |
| 20 | Tue 5 Apr 2022 | 31-1 v Charlton AthleticAFC Wimbledon 1-1 Charlton Athletic | Sky Bet League One |
| 21 | Sat 30 Apr 2022 | 33-4 v Accrington StanleyAFC Wimbledon 3-4 Accrington Stanley | Sky Bet League One |
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