| 1 | Sat 7 Aug 2021 | 9 1-2 v SunderlandSunderland 2-1 Wigan Athletic | Sky Bet League One |
| 2 | Sat 14 Aug 2021 | 9 1-0 v Rotherham UnitedWigan Athletic 1-0 Rotherham United | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 9 1-1 v Wycombe WanderersWigan Athletic 1-1 Wycombe Wanderers | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 92-0 v Charlton AthleticCharlton Athletic 0-2 Wigan Athletic | Sky Bet League One |
| 5 | Sat 28 Aug 2021 | 91-0 v PortsmouthWigan Athletic 1-0 Portsmouth | Sky Bet League One |
| 6 | Sat 11 Sep 2021 | 9 2-1 v Doncaster RoversWigan Athletic 2-1 Doncaster Rovers | Sky Bet League One |
| 7 | Sat 18 Sep 2021 | 94-1 v Accrington StanleyAccrington Stanley 1-4 Wigan Athletic | Sky Bet League One |
| 8 | Sat 25 Sep 2021 | 92-0 v Cheltenham TownWigan Athletic 2-0 Cheltenham Town | Sky Bet League One |
| 9 | Tue 28 Sep 2021 | 91-2 v Sheffield WednesdayWigan Athletic 1-2 Sheffield Wednesday | Sky Bet League One |
| 10 | Sat 2 Oct 2021 | 92-0 v GillinghamGillingham 0-2 Wigan Athletic | Sky Bet League One |
| 11 | Sat 16 Oct 2021 | 94-0 v Bolton WanderersBolton Wanderers 0-4 Wigan Athletic | Sky Bet League One |
| 12 | Tue 19 Oct 2021 | 91-2 v Milton Keynes DonsWigan Athletic 1-2 Milton Keynes Dons | Sky Bet League One |
| 13 | Sat 23 Oct 2021 | 92-0 v AFC WimbledonAFC Wimbledon 0-2 Wigan Athletic | Sky Bet League One |
| 14 | Sat 30 Oct 2021 | 92-0 v Burton AlbionWigan Athletic 2-0 Burton Albion | Sky Bet League One |
| 15 | Tue 2 Nov 2021 | 93-2 v Fleetwood TownFleetwood Town 2-3 Wigan Athletic | Sky Bet League One |
| 16 | Sat 6 Nov 2021 | 90-0 v Solihull MoorsWigan Athletic 0-0 Solihull Moors | Emirates FA Cup First Round |
| 17 | Tue 16 Nov 2021 | 92-1 v Solihull MoorsSolihull Moors 1-2 Wigan Athletic | Emirates FA Cup First Round Replay |
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