| 1 | Sat 7 Aug 2021 | 111-2 v Wycombe WanderersWycombe Wanderers 2-1 Accrington Stanley | Sky Bet League One |
| 2 | Sat 14 Aug 2021 | 112-1 v Cambridge UnitedAccrington Stanley 2-1 Cambridge United | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 111-0 v Doncaster RoversAccrington Stanley 1-0 Doncaster Rovers | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 111-0 v Crewe AlexandraCrewe Alexandra 0-1 Accrington Stanley | Sky Bet League One |
| 5 | Sat 28 Aug 2021 | 110-2 v Milton Keynes DonsMilton Keynes Dons 2-0 Accrington Stanley | Sky Bet League One |
| 6 | Sat 4 Sep 2021 | 111-0 v Shrewsbury TownAccrington Stanley 1-0 Shrewsbury Town | Sky Bet League One |
| 7 | Sat 11 Sep 2021 | 111-2 v SunderlandSunderland 2-1 Accrington Stanley | Sky Bet League One |
| 8 | Sat 18 Sep 2021 | 111-4 v Wigan AthleticAccrington Stanley 1-4 Wigan Athletic | Sky Bet League One |
| 9 | Sat 25 Sep 2021 | 113-3 v MorecambeMorecambe 3-3 Accrington Stanley | Sky Bet League One |
| 10 | Tue 28 Sep 2021 | 11 1-5 v Oxford UnitedOxford United 5-1 Accrington Stanley | Sky Bet League One |
| 11 | Sat 2 Oct 2021 | 112-1 v Ipswich TownAccrington Stanley 2-1 Ipswich Town | Sky Bet League One |
| 12 | Sat 16 Oct 2021 | 110-1 v Cheltenham TownCheltenham Town 1-0 Accrington Stanley | Sky Bet League One |
| 13 | Tue 19 Oct 2021 | 113-2 v Charlton AthleticCharlton Athletic 2-3 Accrington Stanley | Sky Bet League One |
| 14 | Sat 23 Oct 2021 | 112-2 v PortsmouthAccrington Stanley 2-2 Portsmouth | Sky Bet League One |
| 15 | Sat 30 Oct 2021 | 110-0 v GillinghamGillingham 0-0 Accrington Stanley | Sky Bet League One |
| 16 | Sat 13 Nov 2021 | 111-4 v Plymouth ArgyleAccrington Stanley 1-4 Plymouth Argyle | Sky Bet League One |
| 17 | Sat 20 Nov 2021 | 112-3 v Sheffield WednesdayAccrington Stanley 2-3 Sheffield Wednesday | Sky Bet League One |
| 18 | Tue 23 Nov 2021 | 110-4 v Burton AlbionBurton Albion 4-0 Accrington Stanley | Sky Bet League One |
| 19 | Sat 27 Nov 2021 | 111-0 v Lincoln CityLincoln City 0-1 Accrington Stanley | Sky Bet League One |
| 20 | Sat 4 Dec 2021 | 115-1 v Fleetwood TownAccrington Stanley 5-1 Fleetwood Town | Sky Bet League One |
| 21 | Tue 7 Dec 2021 | 110-2 v AFC WimbledonAccrington Stanley 0-2 AFC Wimbledon | Sky Bet League One |
| 22 | Sat 11 Dec 2021 | 111-0 v Bolton WanderersAccrington Stanley 1-0 Bolton Wanderers | Sky Bet League One |
| 23 | Sun 26 Dec 2021 | 111-0 v Rotherham UnitedAccrington Stanley 1-0 Rotherham United | Sky Bet League One |
| 24 | Wed 29 Dec 2021 | 110-0 v Shrewsbury TownShrewsbury Town 0-0 Accrington Stanley | Sky Bet League One |
| 25 | Sat 8 Jan 2022 | 111-1 v Milton Keynes DonsAccrington Stanley 1-1 Milton Keynes Dons | Sky Bet League One |
| 26 | Sat 15 Jan 2022 | 111-1 v SunderlandAccrington Stanley 1-1 Sunderland | Sky Bet League One |
| 27 | Sat 22 Jan 2022 | 111-2 v Ipswich TownIpswich Town 2-1 Accrington Stanley | Sky Bet League One |
| 28 | Sat 29 Jan 2022 | 112-2 v MorecambeAccrington Stanley 2-2 Morecambe | Sky Bet League One |
| 29 | Sat 5 Feb 2022 | 11 0-1 v Rotherham UnitedRotherham United 1-0 Accrington Stanley | Sky Bet League One |
| 30 | Tue 8 Feb 2022 | 112-0 v Oxford UnitedAccrington Stanley 2-0 Oxford United | Sky Bet League One |
| 31 | Sat 12 Feb 2022 | 114-1 v Crewe AlexandraAccrington Stanley 4-1 Crewe Alexandra | Sky Bet League One |
| 32 | Sat 19 Feb 2022 | 110-2 v Cambridge UnitedCambridge United 2-0 Accrington Stanley | Sky Bet League One |
| 33 | Tue 22 Feb 2022 | 110-2 v Doncaster RoversDoncaster Rovers 2-0 Accrington Stanley | Sky Bet League One |
| 34 | Sat 26 Feb 2022 | 113-2 v Wycombe WanderersAccrington Stanley 3-2 Wycombe Wanderers | Sky Bet League One |
| 35 | Sat 5 Mar 2022 | 110-4 v PortsmouthPortsmouth 4-0 Accrington Stanley | Sky Bet League One |
| 36 | Sat 12 Mar 2022 | 112-1 v Charlton AthleticAccrington Stanley 2-1 Charlton Athletic | Sky Bet League One |
| 37 | Tue 15 Mar 2022 | 111-1 v Sheffield WednesdaySheffield Wednesday 1-1 Accrington Stanley | Sky Bet League One |
| 38 | Sat 19 Mar 2022 | 110-4 v Plymouth ArgylePlymouth Argyle 4-0 Accrington Stanley | Sky Bet League One |
| 39 | Sat 26 Mar 2022 | 111-2 v GillinghamAccrington Stanley 1-2 Gillingham | Sky Bet League One |
| 40 | Sat 2 Apr 2022 | 114-4 v Cheltenham TownAccrington Stanley 4-4 Cheltenham Town | Sky Bet League One |
| 41 | Tue 5 Apr 2022 | 110-3 v Wigan AthleticWigan Athletic 3-0 Accrington Stanley | Sky Bet League One |
| 42 | Sat 9 Apr 2022 | 112-1 v Fleetwood TownFleetwood Town 1-2 Accrington Stanley | Sky Bet League One |
| 43 | Fri 15 Apr 2022 | 11 0-0 v Burton AlbionAccrington Stanley 0-0 Burton Albion | Sky Bet League One |
| 44 | Mon 18 Apr 2022 | 11 1-3 v Bolton WanderersBolton Wanderers 3-1 Accrington Stanley | Sky Bet League One |
| 45 | Sat 23 Apr 2022 | 112-1 v Lincoln CityAccrington Stanley 2-1 Lincoln City | Sky Bet League One |
| 46 | Sat 30 Apr 2022 | 114-3 v AFC WimbledonAFC Wimbledon 3-4 Accrington Stanley | Sky Bet League One |
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