| 1 | Sun 1 Aug 2021 | 80-0 v Huddersfield TownSheffield Wednesday 0-0 Huddersfield Town | Carabao Cup First Round |
| 2 | Sat 7 Aug 2021 | 80-0 v Charlton AthleticCharlton Athletic 0-0 Sheffield Wednesday | Sky Bet League One |
| 3 | Sat 14 Aug 2021 | 82-0 v Doncaster RoversSheffield Wednesday 2-0 Doncaster Rovers | Sky Bet League One |
| 4 | Tue 17 Aug 2021 | 81-0 v Fleetwood TownSheffield Wednesday 1-0 Fleetwood Town | Sky Bet League One |
| 5 | Sat 21 Aug 2021 | 8 2-0 v Rotherham UnitedRotherham United 0-2 Sheffield Wednesday | Sky Bet League One |
| 6 | Sat 28 Aug 2021 | 80-1 v MorecambeMorecambe 1-0 Sheffield Wednesday | Sky Bet League One |
| 7 | Sat 18 Sep 2021 | 81-1 v Shrewsbury TownSheffield Wednesday 1-1 Shrewsbury Town | Sky Bet League One |
| 8 | Sat 25 Sep 2021 | 81-1 v Ipswich TownIpswich Town 1-1 Sheffield Wednesday | Sky Bet League One |
| 9 | Tue 28 Sep 2021 | 82-1 v Wigan AthleticWigan Athletic 1-2 Sheffield Wednesday | Sky Bet League One |
| 10 | Sat 2 Oct 2021 | 81-2 v Oxford UnitedSheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 11 | Sat 9 Oct 2021 | 81-0 v Bolton WanderersSheffield Wednesday 1-0 Bolton Wanderers | Sky Bet League One |
| 12 | Tue 19 Oct 2021 | 81-1 v Cambridge UnitedCambridge United 1-1 Sheffield Wednesday | Sky Bet League One |
| 13 | Sat 23 Oct 2021 | 81-1 v Lincoln CitySheffield Wednesday 1-1 Lincoln City | Sky Bet League One |
| 14 | Sat 30 Oct 2021 | 82-2 v Cheltenham TownCheltenham Town 2-2 Sheffield Wednesday | Sky Bet League One |
| 15 | Tue 2 Nov 2021 | 8 3-0 v SunderlandSheffield Wednesday 3-0 Sunderland | Sky Bet League One |
| 16 | Sun 7 Nov 2021 | 8 0-0 v Plymouth ArgyleSheffield Wednesday 0-0 Plymouth Argyle | Emirates FA Cup First Round |
| 17 | Tue 9 Nov 2021 | 84-0 v Harrogate TownSheffield Wednesday 4-0 Harrogate Town | Papa John’s Trophy |
| 18 | Sat 13 Nov 2021 | 81-1 v GillinghamSheffield Wednesday 1-1 Gillingham | Sky Bet League One |
| 19 | Tue 16 Nov 2021 | 80-3 v Plymouth ArgylePlymouth Argyle 3-0 Sheffield Wednesday | Emirates FA Cup First Round Replay |
| 20 | Thu 30 Dec 2021 | 80-5 v SunderlandSunderland 5-0 Sheffield Wednesday | Sky Bet League One |
| 21 | Sun 2 Jan 2022 | 8 0-1 v Shrewsbury TownShrewsbury Town 1-0 Sheffield Wednesday | Sky Bet League One |
| 22 | Sat 15 Jan 2022 | 84-2 v Plymouth ArgyleSheffield Wednesday 4-2 Plymouth Argyle | Sky Bet League One |
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