| 1 | Sat 7 Aug 2021 | 61-1 v Cheltenham TownCrewe Alexandra 1-1 Cheltenham Town | Sky Bet League One |
| 2 | Sat 14 Aug 2021 | 60-2 v PortsmouthPortsmouth 2-0 Crewe Alexandra | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 6 0-1 v Oxford UnitedOxford United 1-0 Crewe Alexandra | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 6 0-1 v Accrington StanleyCrewe Alexandra 0-1 Accrington Stanley | Sky Bet League One |
| 5 | Sat 28 Aug 2021 | 60-2 v Charlton AthleticCharlton Athletic 2-0 Crewe Alexandra | Sky Bet League One |
| 6 | Sat 11 Sep 2021 | 61-1 v Shrewsbury TownShrewsbury Town 1-1 Crewe Alexandra | Sky Bet League One |
| 7 | Sat 18 Sep 2021 | 62-0 v Burton AlbionCrewe Alexandra 2-0 Burton Albion | Sky Bet League One |
| 8 | Sat 25 Sep 2021 | 61-1 v Rotherham UnitedRotherham United 1-1 Crewe Alexandra | Sky Bet League One |
| 9 | Tue 28 Sep 2021 | 6 1-1 v Plymouth ArgylePlymouth Argyle 1-1 Crewe Alexandra | Sky Bet League One |
| 10 | Sat 2 Oct 2021 | 62-2 v Cambridge UnitedCrewe Alexandra 2-2 Cambridge United | Sky Bet League One |
| 11 | Tue 5 Oct 2021 | 62-0 v Wigan AthleticCrewe Alexandra 2-0 Wigan Athletic | Papa John’s Trophy |
| 12 | Sat 16 Oct 2021 | 60-3 v Fleetwood TownFleetwood Town 3-0 Crewe Alexandra | Sky Bet League One |
| 13 | Tue 19 Oct 2021 | 60-4 v SunderlandCrewe Alexandra 0-4 Sunderland | Sky Bet League One |
| 14 | Sat 23 Oct 2021 | 6 1-2 v Wycombe WanderersWycombe Wanderers 2-1 Crewe Alexandra | Sky Bet League One |
| 15 | Sat 30 Oct 2021 | 61-4 v Milton Keynes DonsCrewe Alexandra 1-4 Milton Keynes Dons | Sky Bet League One |
| 16 | Tue 2 Nov 2021 | 61-1 v Doncaster RoversCrewe Alexandra 1-1 Doncaster Rovers | Sky Bet League One |
| 17 | Sat 6 Nov 2021 | 60-3 v Swindon TownCrewe Alexandra 0-3 Swindon Town | Emirates FA Cup First Round |
| 18 | Fri 12 Nov 2021 | 6 0-2 v Bolton WanderersBolton Wanderers 2-0 Crewe Alexandra | Sky Bet League One |
| 19 | Sat 20 Nov 2021 | 6 2-0 v GillinghamCrewe Alexandra 2-0 Gillingham | Sky Bet League One |
| 20 | Sun 28 Nov 2021 | 61-2 v Ipswich TownIpswich Town 2-1 Crewe Alexandra | Sky Bet League One |
| 21 | Tue 7 Dec 2021 | 62-0 v Lincoln CityCrewe Alexandra 2-0 Lincoln City | Sky Bet League One |
| 22 | Sat 11 Dec 2021 | 60-2 v Sheffield WednesdayCrewe Alexandra 0-2 Sheffield Wednesday | Sky Bet League One |
| 23 | Wed 29 Dec 2021 | 62-1 v MorecambeMorecambe 1-2 Crewe Alexandra | Sky Bet League One |
| 24 | Sat 1 Jan 2022 | 6 1-4 v Burton AlbionBurton Albion 4-1 Crewe Alexandra | Sky Bet League One |
| 25 | Wed 12 Jan 2022 | 62-1 v Charlton AthleticCrewe Alexandra 2-1 Charlton Athletic | Sky Bet League One |
| 26 | Sat 15 Jan 2022 | 60-0 v Shrewsbury TownCrewe Alexandra 0-0 Shrewsbury Town | Sky Bet League One |
| 27 | Sat 22 Jan 2022 | 6 0-1 v Cambridge UnitedCambridge United 1-0 Crewe Alexandra | Sky Bet League One |
| 28 | Sat 29 Jan 2022 | 60-2 v Rotherham UnitedCrewe Alexandra 0-2 Rotherham United | Sky Bet League One |
| 29 | Tue 1 Feb 2022 | 60-1 v GillinghamGillingham 1-0 Crewe Alexandra | Sky Bet League One |
| 30 | Tue 8 Feb 2022 | 61-4 v Plymouth ArgyleCrewe Alexandra 1-4 Plymouth Argyle | Sky Bet League One |
| 31 | Sat 12 Feb 2022 | 61-4 v Accrington StanleyAccrington Stanley 4-1 Crewe Alexandra | Sky Bet League One |
| 32 | Tue 15 Feb 2022 | 60-2 v Wigan AthleticWigan Athletic 2-0 Crewe Alexandra | Sky Bet League One |
| 33 | Tue 22 Feb 2022 | 6 0-1 v Oxford UnitedCrewe Alexandra 0-1 Oxford United | Sky Bet League One |
| 34 | Sat 26 Feb 2022 | 62-1 v Cheltenham TownCheltenham Town 1-2 Crewe Alexandra | Sky Bet League One |
| 35 | Sat 5 Mar 2022 | 6 1-3 v Wycombe WanderersCrewe Alexandra 1-3 Wycombe Wanderers | Sky Bet League One |
| 36 | Tue 8 Mar 2022 | 61-3 v PortsmouthCrewe Alexandra 1-3 Portsmouth | Sky Bet League One |
| 37 | Sat 12 Mar 2022 | 60-2 v SunderlandSunderland 2-0 Crewe Alexandra | Sky Bet League One |
| 38 | Tue 15 Mar 2022 | 60-2 v Wigan AthleticCrewe Alexandra 0-2 Wigan Athletic | Sky Bet League One |
| 39 | Sat 19 Mar 2022 | 60-1 v Bolton WanderersCrewe Alexandra 0-1 Bolton Wanderers | Sky Bet League One |
| 40 | Sat 2 Apr 2022 | 61-3 v Fleetwood TownCrewe Alexandra 1-3 Fleetwood Town | Sky Bet League One |
| 41 | Tue 5 Apr 2022 | 61-2 v Milton Keynes DonsMilton Keynes Dons 2-1 Crewe Alexandra | Sky Bet League One |
| 42 | Sat 9 Apr 2022 | 60-2 v Doncaster RoversDoncaster Rovers 2-0 Crewe Alexandra | Sky Bet League One |
| 43 | Fri 15 Apr 2022 | 63-1 v AFC WimbledonCrewe Alexandra 3-1 AFC Wimbledon | Sky Bet League One |
| 44 | Tue 19 Apr 2022 | 60-1 v Sheffield WednesdaySheffield Wednesday 1-0 Crewe Alexandra | Sky Bet League One |
| 45 | Sat 23 Apr 2022 | 61-1 v Ipswich TownCrewe Alexandra 1-1 Ipswich Town | Sky Bet League One |
| 46 | Sat 30 Apr 2022 | 61-2 v Lincoln CityLincoln City 2-1 Crewe Alexandra | Sky Bet League One |
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