| 1 | Tue 21 Sep 2021 | 160-2 v SunderlandWigan Athletic 0-2 Sunderland | Carabao Cup Third Round |
| 2 | Sat 25 Sep 2021 | 162-0 v Cheltenham TownWigan Athletic 2-0 Cheltenham Town | Sky Bet League One |
| 3 | Tue 5 Oct 2021 | 160-2 v Crewe AlexandraCrewe Alexandra 2-0 Wigan Athletic | Papa John’s Trophy |
| 4 | Sat 30 Oct 2021 | 162-0 v Burton AlbionWigan Athletic 2-0 Burton Albion | Sky Bet League One |
| 5 | Tue 2 Nov 2021 | 163-2 v Fleetwood TownFleetwood Town 2-3 Wigan Athletic | Sky Bet League One |
| 6 | Sat 6 Nov 2021 | 160-0 v Solihull MoorsWigan Athletic 0-0 Solihull Moors | Emirates FA Cup First Round |
| 7 | Tue 23 Nov 2021 | 162-2 v Cambridge UnitedCambridge United 2-2 Wigan Athletic | Sky Bet League One |
| 8 | Sat 27 Nov 2021 | 162-1 v Plymouth ArgylePlymouth Argyle 1-2 Wigan Athletic | Sky Bet League One |
| 9 | Wed 8 Dec 2021 | 162-1 v Shrewsbury TownWigan Athletic 2-1 Shrewsbury Town | Sky Bet League One |
| 10 | Sat 11 Dec 2021 | 161-1 v Ipswich TownWigan Athletic 1-1 Ipswich Town | Sky Bet League One |
| 11 | Sat 18 Dec 2021 | 163-2 v Oxford UnitedOxford United 2-3 Wigan Athletic | Sky Bet League One |
| 12 | Tue 4 Jan 2022 | 166-0 v Oldham AthleticOldham Athletic 0-6 Wigan Athletic | Papa John’s Trophy Third Round |
| 13 | Tue 1 Feb 2022 | 161-1 v Oxford UnitedWigan Athletic 1-1 Oxford United | Sky Bet League One |
| 14 | Tue 8 Feb 2022 | 160-1 v Sheffield WednesdaySheffield Wednesday 1-0 Wigan Athletic | Sky Bet League One |
| 15 | Sat 12 Feb 2022 | 162-1 v Charlton AthleticWigan Athletic 2-1 Charlton Athletic | Sky Bet League One |
| 16 | Fri 18 Feb 2022 | 161-1 v Rotherham UnitedRotherham United 1-1 Wigan Athletic | Sky Bet League One |
| 17 | Tue 22 Feb 2022 | 16 3-1 v Wycombe WanderersWycombe Wanderers 1-3 Wigan Athletic | Sky Bet League One |
| 18 | Sat 26 Feb 2022 | 16 0-3 v SunderlandWigan Athletic 0-3 Sunderland | Sky Bet League One |
| 19 | Tue 1 Mar 2022 | 162-0 v Fleetwood TownWigan Athletic 2-0 Fleetwood Town | Sky Bet League One |
| 20 | Sat 5 Mar 2022 | 161-0 v AFC WimbledonWigan Athletic 1-0 AFC Wimbledon | Sky Bet League One |
| 21 | Sat 12 Mar 2022 | 16 1-1 v Milton Keynes DonsMilton Keynes Dons 1-1 Wigan Athletic | Sky Bet League One |
| 22 | Tue 15 Mar 2022 | 162-0 v Crewe AlexandraCrewe Alexandra 0-2 Wigan Athletic | Sky Bet League One |
| 23 | Sat 19 Mar 2022 | 164-1 v MorecambeWigan Athletic 4-1 Morecambe | Sky Bet League One |
| 24 | Sat 2 Apr 2022 | 161-1 v Bolton WanderersWigan Athletic 1-1 Bolton Wanderers | Sky Bet League One |
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