| 1 | Sat 7 Aug 2021 | 3 1-0 v Fleetwood TownFleetwood Town 0-1 Portsmouth | Sky Bet League One |
| 2 | Sat 14 Aug 2021 | 32-0 v Crewe AlexandraPortsmouth 2-0 Crewe Alexandra | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 31-0 v Shrewsbury TownPortsmouth 1-0 Shrewsbury Town | Sky Bet League One |
| 4 | Sat 28 Aug 2021 | 30-1 v Wigan AthleticWigan Athletic 1-0 Portsmouth | Sky Bet League One |
| 5 | Sat 11 Sep 2021 | 30-1 v Milton Keynes DonsMilton Keynes Dons 1-0 Portsmouth | Sky Bet League One |
| 6 | Sat 18 Sep 2021 | 3 1-2 v Cambridge UnitedPortsmouth 1-2 Cambridge United | Sky Bet League One |
| 7 | Tue 21 Sep 2021 | 32-2 v Plymouth ArgylePortsmouth 2-2 Plymouth Argyle | Sky Bet League One |
| 8 | Sat 25 Sep 2021 | 3 2-2 v Charlton AthleticCharlton Athletic 2-2 Portsmouth | Sky Bet League One |
| 9 | Tue 28 Sep 2021 | 3 1-2 v Burton AlbionBurton Albion 2-1 Portsmouth | Sky Bet League One |
| 10 | Sat 2 Oct 2021 | 34-0 v SunderlandPortsmouth 4-0 Sunderland | Sky Bet League One |
| 11 | Tue 12 Oct 2021 | 30-2 v Sutton UnitedPortsmouth 0-2 Sutton United | Papa John’s Trophy |
| 12 | Sat 16 Oct 2021 | 31-4 v Rotherham UnitedRotherham United 4-1 Portsmouth | Sky Bet League One |
| 13 | Tue 19 Oct 2021 | 30-4 v Ipswich TownPortsmouth 0-4 Ipswich Town | Sky Bet League One |
| 14 | Sat 23 Oct 2021 | 32-2 v Accrington StanleyAccrington Stanley 2-2 Portsmouth | Sky Bet League One |
| 15 | Sat 30 Oct 2021 | 31-0 v Bolton WanderersPortsmouth 1-0 Bolton Wanderers | Sky Bet League One |
| 16 | Tue 2 Nov 2021 | 31-1 v Cheltenham TownPortsmouth 1-1 Cheltenham Town | Sky Bet League One |
| 17 | Sat 6 Nov 2021 | 31-0 v Harrow BoroughPortsmouth 1-0 Harrow Borough | Emirates FA Cup First Round |
| 18 | Sat 13 Nov 2021 | 31-0 v Wycombe WanderersWycombe Wanderers 0-1 Portsmouth | Sky Bet League One |
| 19 | Sat 20 Nov 2021 | 3 2-1 v AFC WimbledonPortsmouth 2-1 AFC Wimbledon | Sky Bet League One |
| 20 | Sat 4 Dec 2021 | 31-2 v Harrogate TownPortsmouth 1-2 Harrogate Town | Emirates FA Cup Second Round |
| 21 | Mon 3 Jan 2022 | 30-0 v Cambridge UnitedCambridge United 0-0 Portsmouth | Sky Bet League One |
| 22 | Fri 7 Jan 2022 | 33-2 v Exeter CityExeter City 2-3 Portsmouth | Papa John’s Trophy Second Round |
| 23 | Tue 11 Jan 2022 | 31-2 v Cambridge UnitedCambridge United 2-1 Portsmouth | Papa John’s Trophy Third Round |
| 24 | Tue 18 Jan 2022 | 30-0 v AFC WimbledonAFC Wimbledon 0-0 Portsmouth | Sky Bet League One |
| 25 | Sat 29 Jan 2022 | 551-1 v Shrewsbury TownAFC Wimbledon 1-1 Shrewsbury Town | Sky Bet League One |
| 26 | Tue 1 Feb 2022 | 55 2-2 v Cheltenham TownAFC Wimbledon 2-2 Cheltenham Town | Sky Bet League One |
| 27 | Sat 5 Feb 2022 | 552-3 v Charlton AthleticCharlton Athletic 3-2 AFC Wimbledon | Sky Bet League One |
| 28 | Sat 12 Feb 2022 | 551-1 v SunderlandAFC Wimbledon 1-1 Sunderland | Sky Bet League One |
| 29 | Sat 19 Feb 2022 | 550-4 v Bolton WanderersBolton Wanderers 4-0 AFC Wimbledon | Sky Bet League One |
| 30 | Tue 22 Feb 2022 | 550-0 v GillinghamGillingham 0-0 AFC Wimbledon | Sky Bet League One |
| 31 | Sat 26 Feb 2022 | 552-2 v Doncaster RoversAFC Wimbledon 2-2 Doncaster Rovers | Sky Bet League One |
| 32 | Sat 5 Mar 2022 | 550-1 v Wigan AthleticWigan Athletic 1-0 AFC Wimbledon | Sky Bet League One |
| 33 | Tue 8 Mar 2022 | 550-2 v Plymouth ArgylePlymouth Argyle 2-0 AFC Wimbledon | Sky Bet League One |
| 34 | Sat 12 Mar 2022 | 55 0-2 v Lincoln CityAFC Wimbledon 0-2 Lincoln City | Sky Bet League One |
| 35 | Sat 26 Mar 2022 | 550-1 v Cambridge UnitedAFC Wimbledon 0-1 Cambridge United | Sky Bet League One |
| 36 | Fri 15 Apr 2022 | 551-3 v Crewe AlexandraCrewe Alexandra 3-1 AFC Wimbledon | Sky Bet League One |
| 37 | Mon 18 Apr 2022 | 55 1-1 v Wycombe WanderersAFC Wimbledon 1-1 Wycombe Wanderers | Sky Bet League One |
| 38 | Sat 23 Apr 2022 | 55 1-1 v Fleetwood TownFleetwood Town 1-1 AFC Wimbledon | Sky Bet League One |
| 39 | Sat 30 Apr 2022 | 553-4 v Accrington StanleyAFC Wimbledon 3-4 Accrington Stanley | Sky Bet League One |
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