| 1 | Sat 7 Aug 2021 | 43-3 v Bolton WanderersBolton Wanderers 3-3 Milton Keynes Dons | Sky Bet League One |
| 2 | Sat 14 Aug 2021 | 4 1-2 v SunderlandMilton Keynes Dons 1-2 Sunderland | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 42-1 v Charlton AthleticMilton Keynes Dons 2-1 Charlton Athletic | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 4 2-2 v Ipswich TownIpswich Town 2-2 Milton Keynes Dons | Sky Bet League One |
| 5 | Tue 31 Aug 2021 | 4 2-1 v Burton AlbionBurton Albion 1-2 Milton Keynes Dons | Papa John’s Trophy |
| 6 | Tue 28 Sep 2021 | 43-3 v Fleetwood TownMilton Keynes Dons 3-3 Fleetwood Town | Sky Bet League One |
| 7 | Tue 5 Oct 2021 | 42-1 v Wycombe WanderersMilton Keynes Dons 2-1 Wycombe Wanderers | Papa John’s Trophy |
| 8 | Sat 23 Oct 2021 | 40-3 v Rotherham UnitedMilton Keynes Dons 0-3 Rotherham United | Sky Bet League One |
| 9 | Sat 30 Oct 2021 | 44-1 v Crewe AlexandraCrewe Alexandra 1-4 Milton Keynes Dons | Sky Bet League One |
| 10 | Tue 4 Jan 2022 | 40-1 v Charlton AthleticCharlton Athletic 1-0 Milton Keynes Dons | Papa John’s Trophy Third Round |
| 11 | Sat 15 Jan 2022 | 41-0 v Rotherham UnitedFleetwood Town 1-0 Rotherham United | Sky Bet League One |
| 12 | Sat 22 Jan 2022 | 40-2 v Charlton AthleticCharlton Athletic 2-0 Fleetwood Town | Sky Bet League One |
| 13 | Tue 25 Jan 2022 | 4 3-3 v Plymouth ArgyleFleetwood Town 3-3 Plymouth Argyle | Sky Bet League One |
| 14 | Sat 29 Jan 2022 | 41-1 v Cambridge UnitedFleetwood Town 1-1 Cambridge United | Sky Bet League One |
| 15 | Sat 5 Feb 2022 | 41-1 v Shrewsbury TownShrewsbury Town 1-1 Fleetwood Town | Sky Bet League One |
| 16 | Sat 12 Feb 2022 | 40-2 v Cheltenham TownCheltenham Town 2-0 Fleetwood Town | Sky Bet League One |
| 17 | Sat 26 Feb 2022 | 43-3 v PortsmouthPortsmouth 3-3 Fleetwood Town | Sky Bet League One |
| 18 | Tue 1 Mar 2022 | 40-2 v Wigan AthleticWigan Athletic 2-0 Fleetwood Town | Sky Bet League One |
| 19 | Sat 5 Mar 2022 | 40-2 v Ipswich TownFleetwood Town 0-2 Ipswich Town | Sky Bet League One |
| 20 | Tue 8 Mar 2022 | 4 1-3 v SunderlandSunderland 3-1 Fleetwood Town | Sky Bet League One |
| 21 | Tue 15 Mar 2022 | 40-1 v Wycombe WanderersWycombe Wanderers 1-0 Fleetwood Town | Sky Bet League One |
| 22 | Sat 19 Mar 2022 | 40-0 v Doncaster RoversFleetwood Town 0-0 Doncaster Rovers | Sky Bet League One |
| 23 | Sat 2 Apr 2022 | 43-1 v Crewe AlexandraCrewe Alexandra 1-3 Fleetwood Town | Sky Bet League One |
| 24 | Tue 5 Apr 2022 | 41-1 v Lincoln CityFleetwood Town 1-1 Lincoln City | Sky Bet League One |
| 25 | Sat 9 Apr 2022 | 41-2 v Accrington StanleyFleetwood Town 1-2 Accrington Stanley | Sky Bet League One |
| 26 | Fri 15 Apr 2022 | 42-3 v Oxford UnitedFleetwood Town 2-3 Oxford United | Sky Bet League One |
| 27 | Mon 18 Apr 2022 | 40-0 v GillinghamGillingham 0-0 Fleetwood Town | Sky Bet League One |
| 28 | Sat 23 Apr 2022 | 41-1 v AFC WimbledonFleetwood Town 1-1 AFC Wimbledon | Sky Bet League One |
| 29 | Tue 26 Apr 2022 | 42-3 v Sheffield WednesdayFleetwood Town 2-3 Sheffield Wednesday | Sky Bet League One |
| 30 | Sat 30 Apr 2022 | 42-4 v Bolton WanderersBolton Wanderers 4-2 Fleetwood Town | Sky Bet League One |
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