| 1 | Tue 10 Aug 2021 | 202-2 v StevenageStevenage 2-2 Luton Town | Carabao Cup First Round |
| 2 | Sat 14 Aug 2021 | 202-3 v West Bromwich AlbionWest Bromwich Albion 3-2 Luton Town | Sky Bet Championship |
| 3 | Tue 17 Aug 2021 | 201-0 v BarnsleyBarnsley 0-1 Luton Town | Sky Bet Championship |
| 4 | Sat 21 Aug 2021 | 200-5 v Birmingham CityLuton Town 0-5 Birmingham City | Sky Bet Championship |
| 5 | Sat 4 Sep 2021 | 301-1 v Cheltenham TownCheltenham Town 1-1 Milton Keynes Dons | Sky Bet League One |
| 6 | Sat 11 Sep 2021 | 301-0 v PortsmouthMilton Keynes Dons 1-0 Portsmouth | Sky Bet League One |
| 7 | Sat 18 Sep 2021 | 30 4-1 v GillinghamGillingham 1-4 Milton Keynes Dons | Sky Bet League One |
| 8 | Tue 28 Sep 2021 | 303-3 v Fleetwood TownMilton Keynes Dons 3-3 Fleetwood Town | Sky Bet League One |
| 9 | Sat 2 Oct 2021 | 301-2 v Doncaster RoversDoncaster Rovers 2-1 Milton Keynes Dons | Sky Bet League One |
| 10 | Tue 5 Oct 2021 | 302-1 v Wycombe WanderersMilton Keynes Dons 2-1 Wycombe Wanderers | Papa John’s Trophy |
| 11 | Sat 16 Oct 2021 | 300-1 v Shrewsbury TownShrewsbury Town 1-0 Milton Keynes Dons | Sky Bet League One |
| 12 | Tue 19 Oct 2021 | 302-1 v Wigan AthleticWigan Athletic 1-2 Milton Keynes Dons | Sky Bet League One |
| 13 | Sat 23 Oct 2021 | 300-3 v Rotherham UnitedMilton Keynes Dons 0-3 Rotherham United | Sky Bet League One |
| 14 | Sat 30 Oct 2021 | 304-1 v Crewe AlexandraCrewe Alexandra 1-4 Milton Keynes Dons | Sky Bet League One |
| 15 | Sat 13 Nov 2021 | 304-1 v Cambridge UnitedMilton Keynes Dons 4-1 Cambridge United | Sky Bet League One |
| 16 | Sat 20 Nov 2021 | 301-0 v Burton AlbionMilton Keynes Dons 1-0 Burton Albion | Sky Bet League One |
| 17 | Tue 23 Nov 2021 | 30 1-2 v Sheffield WednesdaySheffield Wednesday 2-1 Milton Keynes Dons | Sky Bet League One |
| 18 | Sat 27 Nov 2021 | 304-0 v MorecambeMorecambe 0-4 Milton Keynes Dons | Sky Bet League One |
| 19 | Sun 26 Dec 2021 | 303-2 v Lincoln CityLincoln City 2-3 Milton Keynes Dons | Sky Bet League One |
| 20 | Sat 1 Jan 2022 | 300-0 v GillinghamMilton Keynes Dons 0-0 Gillingham | Sky Bet League One |
| 21 | Sat 8 Jan 2022 | 301-1 v Accrington StanleyAccrington Stanley 1-1 Milton Keynes Dons | Sky Bet League One |
| 22 | Tue 11 Jan 2022 | 301-0 v AFC WimbledonMilton Keynes Dons 1-0 AFC Wimbledon | Sky Bet League One |
| 23 | Sat 15 Jan 2022 | 302-1 v PortsmouthPortsmouth 1-2 Milton Keynes Dons | Sky Bet League One |
| 24 | Wed 19 Jan 2022 | 202-0 v ReadingReading 0-2 Luton Town | Sky Bet Championship |
| 25 | Sat 22 Jan 2022 | 200-2 v Sheffield UnitedSheffield United 2-0 Luton Town | Sky Bet Championship |
| 26 | Tue 25 Jan 2022 | 20 2-1 v Bristol CityLuton Town 2-1 Bristol City | Sky Bet Championship |
| 27 | Sat 5 Feb 2022 | 20 3-0 v Cambridge UnitedCambridge United 0-3 Luton Town | Emirates FA Cup Fourth Round |
| 28 | Tue 8 Feb 2022 | 202-1 v BarnsleyLuton Town 2-1 Barnsley | Sky Bet Championship |
| 29 | Sat 19 Feb 2022 | 202-0 v West Bromwich AlbionLuton Town 2-0 West Bromwich Albion | Sky Bet Championship |
| 30 | Wed 23 Feb 2022 | 202-1 v Stoke CityStoke City 1-2 Luton Town | Sky Bet Championship |
| 31 | Wed 2 Mar 2022 | 202-3 v ChelseaLuton Town 2-3 Chelsea | Emirates FA Cup Fifth Round |
| 32 | Wed 16 Mar 2022 | 204-0 v Preston North EndLuton Town 4-0 Preston North End | Sky Bet Championship |
| 33 | Sat 19 Mar 2022 | 20 3-1 v Hull CityHull City 1-3 Luton Town | Sky Bet Championship |
| 34 | Tue 5 Apr 2022 | 201-1 v Peterborough UnitedPeterborough United 1-1 Luton Town | Sky Bet Championship |
| 35 | Fri 15 Apr 2022 | 201-0 v Nottingham ForestLuton Town 1-0 Nottingham Forest | Sky Bet Championship |
| 36 | Mon 18 Apr 2022 | 201-0 v Cardiff CityCardiff City 0-1 Luton Town | Sky Bet Championship |
| 37 | Sat 23 Apr 2022 | 201-1 v BlackpoolLuton Town 1-1 Blackpool | Sky Bet Championship |
| 38 | Mon 2 May 2022 | 200-7 v FulhamFulham 7-0 Luton Town | Sky Bet Championship |
Football Web Pages