| 1 | Sat 14 Aug 2021 | 11-2 v SunderlandMilton Keynes Dons 1-2 Sunderland | Sky Bet League One |
| 2 | Tue 17 Aug 2021 | 12-1 v Charlton AthleticMilton Keynes Dons 2-1 Charlton Athletic | Sky Bet League One |
| 3 | Sat 21 Aug 2021 | 12-2 v Ipswich TownIpswich Town 2-2 Milton Keynes Dons | Sky Bet League One |
| 4 | Sat 28 Aug 2021 | 12-0 v Accrington StanleyMilton Keynes Dons 2-0 Accrington Stanley | Sky Bet League One |
| 5 | Sat 4 Sep 2021 | 11-1 v Cheltenham TownCheltenham Town 1-1 Milton Keynes Dons | Sky Bet League One |
| 6 | Sat 11 Sep 2021 | 1 1-0 v PortsmouthMilton Keynes Dons 1-0 Portsmouth | Sky Bet League One |
| 7 | Sat 18 Sep 2021 | 14-1 v GillinghamGillingham 1-4 Milton Keynes Dons | Sky Bet League One |
| 8 | Sat 25 Sep 2021 | 11-0 v Wycombe WanderersMilton Keynes Dons 1-0 Wycombe Wanderers | Sky Bet League One |
| 9 | Tue 28 Sep 2021 | 13-3 v Fleetwood TownMilton Keynes Dons 3-3 Fleetwood Town | Sky Bet League One |
| 10 | Sat 2 Oct 2021 | 11-2 v Doncaster RoversDoncaster Rovers 2-1 Milton Keynes Dons | Sky Bet League One |
| 11 | Sat 16 Oct 2021 | 10-1 v Shrewsbury TownShrewsbury Town 1-0 Milton Keynes Dons | Sky Bet League One |
| 12 | Tue 19 Oct 2021 | 12-1 v Wigan AthleticWigan Athletic 1-2 Milton Keynes Dons | Sky Bet League One |
| 13 | Sat 23 Oct 2021 | 10-3 v Rotherham UnitedMilton Keynes Dons 0-3 Rotherham United | Sky Bet League One |
| 14 | Sat 30 Oct 2021 | 14-1 v Crewe AlexandraCrewe Alexandra 1-4 Milton Keynes Dons | Sky Bet League One |
| 15 | Sat 6 Nov 2021 | 12-2 v StevenageMilton Keynes Dons 2-2 Stevenage | Emirates FA Cup First Round |
| 16 | Sat 13 Nov 2021 | 14-1 v Cambridge UnitedMilton Keynes Dons 4-1 Cambridge United | Sky Bet League One |
| 17 | Tue 16 Nov 2021 | 11-2 v StevenageStevenage 2-1 Milton Keynes Dons | Emirates FA Cup First Round Replay |
| 18 | Sat 20 Nov 2021 | 11-0 v Burton AlbionMilton Keynes Dons 1-0 Burton Albion | Sky Bet League One |
| 19 | Tue 23 Nov 2021 | 11-2 v Sheffield WednesdaySheffield Wednesday 2-1 Milton Keynes Dons | Sky Bet League One |
| 20 | Sat 27 Nov 2021 | 14-0 v MorecambeMorecambe 0-4 Milton Keynes Dons | Sky Bet League One |
| 21 | Wed 8 Dec 2021 | 11-1 v Plymouth ArgyleMilton Keynes Dons 1-1 Plymouth Argyle | Sky Bet League One |
| 22 | Sat 11 Dec 2021 | 11-2 v Oxford UnitedMilton Keynes Dons 1-2 Oxford United | Sky Bet League One |
| 23 | Sun 26 Dec 2021 | 13-2 v Lincoln CityLincoln City 2-3 Milton Keynes Dons | Sky Bet League One |
| 24 | Sat 1 Jan 2022 | 10-0 v GillinghamMilton Keynes Dons 0-0 Gillingham | Sky Bet League One |
| 25 | Sat 8 Jan 2022 | 11-1 v Accrington StanleyAccrington Stanley 1-1 Milton Keynes Dons | Sky Bet League One |
| 26 | Tue 1 Feb 2022 | 330-1 v Luton TownSwansea City 0-1 Luton Town | Sky Bet Championship |
| 27 | Sat 5 Feb 2022 | 331-0 v Blackburn RoversSwansea City 1-0 Blackburn Rovers | Sky Bet Championship |
| 28 | Tue 8 Feb 2022 | 330-3 v Stoke CityStoke City 3-0 Swansea City | Sky Bet Championship |
| 29 | Sun 13 Feb 2022 | 333-1 v Bristol CitySwansea City 3-1 Bristol City | Sky Bet Championship |
| 30 | Sat 19 Feb 2022 | 330-4 v Sheffield UnitedSheffield United 4-0 Swansea City | Sky Bet Championship |
| 31 | Mon 28 Feb 2022 | 332-0 v West Bromwich AlbionWest Bromwich Albion 0-2 Swansea City | Sky Bet Championship |
| 32 | Sat 5 Mar 2022 | 333-1 v Coventry CitySwansea City 3-1 Coventry City | Sky Bet Championship |
| 33 | Tue 8 Mar 2022 | 331-5 v FulhamSwansea City 1-5 Fulham | Sky Bet Championship |
| 34 | Sat 12 Mar 2022 | 330-1 v BlackpoolBlackpool 1-0 Swansea City | Sky Bet Championship |
| 35 | Wed 16 Mar 2022 | 333-2 v Peterborough UnitedPeterborough United 2-3 Swansea City | Sky Bet Championship |
| 36 | Sat 19 Mar 2022 | 330-0 v Birmingham CitySwansea City 0-0 Birmingham City | Sky Bet Championship |
| 37 | Sat 2 Apr 2022 | 33 4-0 v Cardiff CityCardiff City 0-4 Swansea City | Sky Bet Championship |
| 38 | Tue 5 Apr 2022 | 331-0 v MillwallMillwall 0-1 Swansea City | Sky Bet Championship |
| 39 | Sat 9 Apr 2022 | 332-1 v Derby CountySwansea City 2-1 Derby County | Sky Bet Championship |
| 40 | Fri 15 Apr 2022 | 331-1 v BarnsleySwansea City 1-1 Barnsley | Sky Bet Championship |
| 41 | Mon 18 Apr 2022 | 334-4 v ReadingReading 4-4 Swansea City | Sky Bet Championship |
| 42 | Sat 23 Apr 2022 | 331-1 v MiddlesbroughSwansea City 1-1 Middlesbrough | Sky Bet Championship |
| 43 | Tue 26 Apr 2022 | 333-3 v AFC BournemouthSwansea City 3-3 AFC Bournemouth | Sky Bet Championship |
| 44 | Sat 30 Apr 2022 | 331-5 v Nottingham ForestNottingham Forest 5-1 Swansea City | Sky Bet Championship |
| 45 | Sat 7 May 2022 | 330-1 v Queens Park RangersSwansea City 0-1 Queens Park Rangers | Sky Bet Championship |
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