| 1 | Sat 7 Aug 2021 | 33-3 v Milton Keynes DonsBolton Wanderers 3-3 Milton Keynes Dons | Sky Bet League One |
| 2 | Sat 14 Aug 2021 | 33-3 v AFC WimbledonAFC Wimbledon 3-3 Bolton Wanderers | Sky Bet League One |
| 3 | Sat 21 Aug 2021 | 32-1 v Oxford UnitedBolton Wanderers 2-1 Oxford United | Sky Bet League One |
| 4 | Sat 28 Aug 2021 | 30-1 v Cambridge UnitedCambridge United 1-0 Bolton Wanderers | Sky Bet League One |
| 5 | Sat 25 Sep 2021 | 30-1 v SunderlandSunderland 1-0 Bolton Wanderers | Sky Bet League One |
| 6 | Tue 28 Sep 2021 | 34-1 v Charlton AthleticCharlton Athletic 1-4 Bolton Wanderers | Sky Bet League One |
| 7 | Sat 2 Oct 2021 | 32-1 v Shrewsbury TownBolton Wanderers 2-1 Shrewsbury Town | Sky Bet League One |
| 8 | Sat 9 Oct 2021 | 30-1 v Sheffield WednesdaySheffield Wednesday 1-0 Bolton Wanderers | Sky Bet League One |
| 9 | Sat 23 Oct 2021 | 32-2 v GillinghamBolton Wanderers 2-2 Gillingham | Sky Bet League One |
| 10 | Sat 30 Oct 2021 | 30-1 v PortsmouthPortsmouth 1-0 Bolton Wanderers | Sky Bet League One |
| 11 | Tue 2 Nov 2021 | 33-0 v RochdaleRochdale 0-3 Bolton Wanderers | Papa John’s Trophy |
| 12 | Sun 7 Nov 2021 | 32-2 v Stockport CountyBolton Wanderers 2-2 Stockport County | Emirates FA Cup First Round |
| 13 | Fri 12 Nov 2021 | 32-0 v Crewe AlexandraBolton Wanderers 2-0 Crewe Alexandra | Sky Bet League One |
| 14 | Wed 17 Nov 2021 | 33-5 v Stockport CountyStockport County 5-3 Bolton Wanderers | Emirates FA Cup First Round Replay |
| 15 | Sat 20 Nov 2021 | 30-1 v Wycombe WanderersWycombe Wanderers 1-0 Bolton Wanderers | Sky Bet League One |
| 16 | Tue 23 Nov 2021 | 33-0 v Doncaster RoversBolton Wanderers 3-0 Doncaster Rovers | Sky Bet League One |
| 17 | Sat 27 Nov 2021 | 32-2 v Cheltenham TownBolton Wanderers 2-2 Cheltenham Town | Sky Bet League One |
| 18 | Tue 7 Dec 2021 | 30-3 v Fleetwood TownFleetwood Town 3-0 Bolton Wanderers | Sky Bet League One |
| 19 | Sat 11 Dec 2021 | 30-1 v Accrington StanleyAccrington Stanley 1-0 Bolton Wanderers | Sky Bet League One |
| 20 | Sat 1 Jan 2022 | 31-2 v Rotherham UnitedRotherham United 2-1 Bolton Wanderers | Sky Bet League One |
| 21 | Tue 4 Jan 2022 | 30-1 v Hartlepool UnitedHartlepool United 1-0 Bolton Wanderers | Papa John’s Trophy Third Round |
| 22 | Tue 11 Jan 2022 | 30-2 v Wycombe WanderersBolton Wanderers 0-2 Wycombe Wanderers | Sky Bet League One |
| 23 | Sat 15 Jan 2022 | 32-0 v Ipswich TownBolton Wanderers 2-0 Ipswich Town | Sky Bet League One |
| 24 | Sat 22 Jan 2022 | 31-0 v Shrewsbury TownShrewsbury Town 0-1 Bolton Wanderers | Sky Bet League One |
| 25 | Sat 29 Jan 2022 | 36-0 v SunderlandBolton Wanderers 6-0 Sunderland | Sky Bet League One |
| 26 | Tue 1 Feb 2022 | 32-0 v Cambridge UnitedBolton Wanderers 2-0 Cambridge United | Sky Bet League One |
| 27 | Sat 5 Feb 2022 | 31-1 v MorecambeMorecambe 1-1 Bolton Wanderers | Sky Bet League One |
| 28 | Tue 8 Feb 2022 | 3 2-1 v Charlton AthleticBolton Wanderers 2-1 Charlton Athletic | Sky Bet League One |
| 29 | Sat 12 Feb 2022 | 33-2 v Oxford UnitedOxford United 2-3 Bolton Wanderers | Sky Bet League One |
| 30 | Tue 15 Feb 2022 | 31-3 v Burton AlbionBurton Albion 3-1 Bolton Wanderers | Sky Bet League One |
| 31 | Sat 19 Feb 2022 | 34-0 v AFC WimbledonBolton Wanderers 4-0 AFC Wimbledon | Sky Bet League One |
| 32 | Tue 22 Feb 2022 | 33-1 v Lincoln CityBolton Wanderers 3-1 Lincoln City | Sky Bet League One |
| 33 | Sat 26 Feb 2022 | 30-2 v Milton Keynes DonsMilton Keynes Dons 2-0 Bolton Wanderers | Sky Bet League One |
| 34 | Sat 5 Mar 2022 | 33-0 v GillinghamGillingham 0-3 Bolton Wanderers | Sky Bet League One |
| 35 | Tue 8 Mar 2022 | 31-1 v MorecambeBolton Wanderers 1-1 Morecambe | Sky Bet League One |
| 36 | Sat 12 Mar 2022 | 30-1 v Plymouth ArgyleBolton Wanderers 0-1 Plymouth Argyle | Sky Bet League One |
| 37 | Sat 19 Mar 2022 | 31-0 v Crewe AlexandraCrewe Alexandra 0-1 Bolton Wanderers | Sky Bet League One |
| 38 | Tue 5 Apr 2022 | 31-1 v PortsmouthBolton Wanderers 1-1 Portsmouth | Sky Bet League One |
| 39 | Sat 9 Apr 2022 | 31-1 v Sheffield WednesdayBolton Wanderers 1-1 Sheffield Wednesday | Sky Bet League One |
| 40 | Fri 15 Apr 2022 | 32-1 v Doncaster RoversDoncaster Rovers 1-2 Bolton Wanderers | Sky Bet League One |
| 41 | Mon 18 Apr 2022 | 3 3-1 v Accrington StanleyBolton Wanderers 3-1 Accrington Stanley | Sky Bet League One |
| 42 | Sat 23 Apr 2022 | 32-1 v Cheltenham TownCheltenham Town 1-2 Bolton Wanderers | Sky Bet League One |
| 43 | Sat 30 Apr 2022 | 34-2 v Fleetwood TownBolton Wanderers 4-2 Fleetwood Town | Sky Bet League One |
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