| 1 | Sat 11 Sep 2021 | 20-0 v Wycombe WanderersOxford United 0-0 Wycombe Wanderers | Sky Bet League One |
| 2 | Sat 18 Sep 2021 | 2 0-1 v Cheltenham TownCheltenham Town 1-0 Oxford United | Sky Bet League One |
| 3 | Sat 25 Sep 2021 | 21-1 v GillinghamOxford United 1-1 Gillingham | Sky Bet League One |
| 4 | Sat 2 Oct 2021 | 22-1 v Sheffield WednesdaySheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 5 | Tue 5 Oct 2021 | 21-2 v StevenageOxford United 1-2 Stevenage | Papa John’s Trophy |
| 6 | Sat 16 Oct 2021 | 21-3 v Plymouth ArgyleOxford United 1-3 Plymouth Argyle | Sky Bet League One |
| 7 | Tue 19 Oct 2021 | 22-0 v Shrewsbury TownOxford United 2-0 Shrewsbury Town | Sky Bet League One |
| 8 | Sat 23 Oct 2021 | 23-1 v Burton AlbionBurton Albion 1-3 Oxford United | Sky Bet League One |
| 9 | Sat 30 Oct 2021 | 23-1 v MorecambeOxford United 3-1 Morecambe | Sky Bet League One |
| 10 | Sun 7 Nov 2021 | 22-2 v Bristol RoversOxford United 2-2 Bristol Rovers | Emirates FA Cup First Round |
| 11 | Sat 13 Nov 2021 | 20-0 v Ipswich TownIpswich Town 0-0 Oxford United | Sky Bet League One |
| 12 | Tue 16 Nov 2021 | 23-4 v Bristol RoversBristol Rovers 4-3 Oxford United | Emirates FA Cup First Round Replay |
| 13 | Tue 23 Nov 2021 | 23-1 v Fleetwood TownOxford United 3-1 Fleetwood Town | Sky Bet League One |
| 14 | Sat 27 Nov 2021 | 20-0 v Rotherham UnitedOxford United 0-0 Rotherham United | Sky Bet League One |
| 15 | Sat 4 Dec 2021 | 21-1 v SunderlandSunderland 1-1 Oxford United | Sky Bet League One |
| 16 | Tue 7 Dec 2021 | 22-1 v Doncaster RoversDoncaster Rovers 1-2 Oxford United | Sky Bet League One |
| 17 | Sat 11 Dec 2021 | 2 2-1 v Milton Keynes DonsMilton Keynes Dons 1-2 Oxford United | Sky Bet League One |
| 18 | Sat 18 Dec 2021 | 22-3 v Wigan AthleticOxford United 2-3 Wigan Athletic | Sky Bet League One |
| 19 | Wed 29 Dec 2021 | 23-0 v AFC WimbledonOxford United 3-0 AFC Wimbledon | Sky Bet League One |
| 20 | Sat 1 Jan 2022 | 21-1 v Cheltenham TownOxford United 1-1 Cheltenham Town | Sky Bet League One |
| 21 | Sat 8 Jan 2022 | 20-2 v Lincoln CityLincoln City 2-0 Oxford United | Sky Bet League One |
| 22 | Sat 15 Jan 2022 | 20-2 v Wycombe WanderersWycombe Wanderers 2-0 Oxford United | Sky Bet League One |
| 23 | Sat 22 Jan 2022 | 23-2 v Sheffield WednesdayOxford United 3-2 Sheffield Wednesday | Sky Bet League One |
| 24 | Sat 29 Jan 2022 | 27-2 v GillinghamGillingham 2-7 Oxford United | Sky Bet League One |
| 25 | Tue 1 Feb 2022 | 21-1 v Wigan AthleticWigan Athletic 1-1 Oxford United | Sky Bet League One |
| 26 | Sat 12 Feb 2022 | 22-3 v Bolton WanderersOxford United 2-3 Bolton Wanderers | Sky Bet League One |
| 27 | Sat 19 Feb 2022 | 24-0 v Charlton AthleticCharlton Athletic 0-4 Oxford United | Sky Bet League One |
| 28 | Tue 22 Feb 2022 | 21-0 v Crewe AlexandraCrewe Alexandra 0-1 Oxford United | Sky Bet League One |
| 29 | Sat 26 Feb 2022 | 24-2 v Cambridge UnitedOxford United 4-2 Cambridge United | Sky Bet League One |
| 30 | Tue 1 Mar 2022 | 2 2-3 v PortsmouthPortsmouth 3-2 Oxford United | Sky Bet League One |
| 31 | Sat 5 Mar 2022 | 24-1 v Burton AlbionOxford United 4-1 Burton Albion | Sky Bet League One |
| 32 | Sat 19 Mar 2022 | 21-1 v Ipswich TownOxford United 1-1 Ipswich Town | Sky Bet League One |
| 33 | Sat 2 Apr 2022 | 20-1 v Plymouth ArgylePlymouth Argyle 1-0 Oxford United | Sky Bet League One |
| 34 | Tue 5 Apr 2022 | 21-2 v MorecambeMorecambe 2-1 Oxford United | Sky Bet League One |
| 35 | Sat 9 Apr 2022 | 21-2 v SunderlandOxford United 1-2 Sunderland | Sky Bet League One |
| 36 | Fri 15 Apr 2022 | 23-2 v Fleetwood TownFleetwood Town 2-3 Oxford United | Sky Bet League One |
| 37 | Tue 19 Apr 2022 | 21-0 v Milton Keynes DonsOxford United 1-0 Milton Keynes Dons | Sky Bet League One |
| 38 | Sat 23 Apr 2022 | 21-2 v Rotherham UnitedRotherham United 2-1 Oxford United | Sky Bet League One |
| 39 | Sat 30 Apr 2022 | 21-1 v Doncaster RoversOxford United 1-1 Doncaster Rovers | Sky Bet League One |
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