| 1 | Tue 17 Aug 2021 | 18 0-1 v Oxford UnitedOxford United 1-0 Crewe Alexandra | Sky Bet League One |
| 2 | Sat 21 Aug 2021 | 180-1 v Accrington StanleyCrewe Alexandra 0-1 Accrington Stanley | Sky Bet League One |
| 3 | Tue 24 Aug 2021 | 180-3 v Leeds UnitedLeeds United 3-0 Crewe Alexandra | Carabao Cup Second Round |
| 4 | Sat 28 Aug 2021 | 180-2 v Charlton AthleticCharlton Athletic 2-0 Crewe Alexandra | Sky Bet League One |
| 5 | Tue 31 Aug 2021 | 181-0 v Shrewsbury TownShrewsbury Town 0-1 Crewe Alexandra | Papa John’s Trophy |
| 6 | Tue 5 Oct 2021 | 18 2-0 v Wigan AthleticCrewe Alexandra 2-0 Wigan Athletic | Papa John’s Trophy |
| 7 | Tue 23 Nov 2021 | 182-3 v AFC WimbledonAFC Wimbledon 3-2 Crewe Alexandra | Sky Bet League One |
| 8 | Sun 28 Nov 2021 | 181-2 v Ipswich TownIpswich Town 2-1 Crewe Alexandra | Sky Bet League One |
| 9 | Tue 7 Dec 2021 | 18 2-0 v Lincoln CityCrewe Alexandra 2-0 Lincoln City | Sky Bet League One |
| 10 | Sat 11 Dec 2021 | 180-2 v Sheffield WednesdayCrewe Alexandra 0-2 Sheffield Wednesday | Sky Bet League One |
| 11 | Tue 4 Jan 2022 | 182-4 v Rotherham UnitedCrewe Alexandra 2-4 Rotherham United | Papa John’s Trophy Third Round |
| 12 | Wed 12 Jan 2022 | 182-1 v Charlton AthleticCrewe Alexandra 2-1 Charlton Athletic | Sky Bet League One |
| 13 | Sat 15 Jan 2022 | 18 0-0 v Shrewsbury TownCrewe Alexandra 0-0 Shrewsbury Town | Sky Bet League One |
| 14 | Sat 22 Jan 2022 | 180-1 v Cambridge UnitedCambridge United 1-0 Crewe Alexandra | Sky Bet League One |
| 15 | Tue 8 Feb 2022 | 181-4 v Plymouth ArgyleCrewe Alexandra 1-4 Plymouth Argyle | Sky Bet League One |
| 16 | Sat 12 Feb 2022 | 181-4 v Accrington StanleyAccrington Stanley 4-1 Crewe Alexandra | Sky Bet League One |
| 17 | Tue 15 Feb 2022 | 180-2 v Wigan AthleticWigan Athletic 2-0 Crewe Alexandra | Sky Bet League One |
| 18 | Tue 22 Feb 2022 | 180-1 v Oxford UnitedCrewe Alexandra 0-1 Oxford United | Sky Bet League One |
| 19 | Sat 26 Feb 2022 | 18 2-1 v Cheltenham TownCheltenham Town 1-2 Crewe Alexandra | Sky Bet League One |
| 20 | Sat 5 Mar 2022 | 18 1-3 v Wycombe WanderersCrewe Alexandra 1-3 Wycombe Wanderers | Sky Bet League One |
| 21 | Tue 8 Mar 2022 | 181-3 v PortsmouthCrewe Alexandra 1-3 Portsmouth | Sky Bet League One |
| 22 | Sat 12 Mar 2022 | 180-2 v SunderlandSunderland 2-0 Crewe Alexandra | Sky Bet League One |
| 23 | Tue 15 Mar 2022 | 180-2 v Wigan AthleticCrewe Alexandra 0-2 Wigan Athletic | Sky Bet League One |
| 24 | Sat 19 Mar 2022 | 180-1 v Bolton WanderersCrewe Alexandra 0-1 Bolton Wanderers | Sky Bet League One |
| 25 | Sat 23 Apr 2022 | 18 1-1 v Ipswich TownCrewe Alexandra 1-1 Ipswich Town | Sky Bet League One |
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