| 1 | Sat 7 Aug 2021 | 231-1 v Cambridge UnitedCambridge United 1-1 Oxford United | Sky Bet League One |
| 2 | Wed 11 Aug 2021 | 23 1-1 v Burton AlbionBurton Albion 1-1 Oxford United | Carabao Cup First Round |
| 3 | Tue 17 Aug 2021 | 231-0 v Crewe AlexandraOxford United 1-0 Crewe Alexandra | Sky Bet League One |
| 4 | Sat 18 Sep 2021 | 230-1 v Cheltenham TownCheltenham Town 1-0 Oxford United | Sky Bet League One |
| 5 | Sat 25 Sep 2021 | 231-1 v GillinghamOxford United 1-1 Gillingham | Sky Bet League One |
| 6 | Tue 28 Sep 2021 | 235-1 v Accrington StanleyOxford United 5-1 Accrington Stanley | Sky Bet League One |
| 7 | Sun 7 Nov 2021 | 232-2 v Bristol RoversOxford United 2-2 Bristol Rovers | Emirates FA Cup First Round |
| 8 | Tue 16 Nov 2021 | 23 3-4 v Bristol RoversBristol Rovers 4-3 Oxford United | Emirates FA Cup First Round Replay |
| 9 | Tue 23 Nov 2021 | 233-1 v Fleetwood TownOxford United 3-1 Fleetwood Town | Sky Bet League One |
| 10 | Sat 22 Jan 2022 | 233-2 v Sheffield WednesdayOxford United 3-2 Sheffield Wednesday | Sky Bet League One |
| 11 | Sat 29 Jan 2022 | 237-2 v GillinghamGillingham 2-7 Oxford United | Sky Bet League One |
| 12 | Tue 1 Feb 2022 | 231-1 v Wigan AthleticWigan Athletic 1-1 Oxford United | Sky Bet League One |
| 13 | Sat 5 Feb 2022 | 233-2 v PortsmouthOxford United 3-2 Portsmouth | Sky Bet League One |
| 14 | Sat 12 Feb 2022 | 232-3 v Bolton WanderersOxford United 2-3 Bolton Wanderers | Sky Bet League One |
| 15 | Sat 12 Mar 2022 | 232-1 v Shrewsbury TownShrewsbury Town 1-2 Oxford United | Sky Bet League One |
| 16 | Sat 19 Mar 2022 | 231-1 v Ipswich TownOxford United 1-1 Ipswich Town | Sky Bet League One |
| 17 | Sat 2 Apr 2022 | 23 0-1 v Plymouth ArgylePlymouth Argyle 1-0 Oxford United | Sky Bet League One |
| 18 | Tue 5 Apr 2022 | 231-2 v MorecambeMorecambe 2-1 Oxford United | Sky Bet League One |
| 19 | Sat 9 Apr 2022 | 231-2 v SunderlandOxford United 1-2 Sunderland | Sky Bet League One |
| 20 | Fri 15 Apr 2022 | 233-2 v Fleetwood TownFleetwood Town 2-3 Oxford United | Sky Bet League One |
| 21 | Tue 19 Apr 2022 | 231-0 v Milton Keynes DonsOxford United 1-0 Milton Keynes Dons | Sky Bet League One |
| 22 | Sat 23 Apr 2022 | 231-2 v Rotherham UnitedRotherham United 2-1 Oxford United | Sky Bet League One |
| 23 | Sat 30 Apr 2022 | 231-1 v Doncaster RoversOxford United 1-1 Doncaster Rovers | Sky Bet League One |
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