| 1 | Sat 7 Aug 2021 | 7 1-1 v Cambridge UnitedCambridge United 1-1 Oxford United | Sky Bet League One |
| 2 | Sat 14 Aug 2021 | 72-1 v Charlton AthleticOxford United 2-1 Charlton Athletic | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 71-0 v Crewe AlexandraOxford United 1-0 Crewe Alexandra | Sky Bet League One |
| 4 | Sat 4 Sep 2021 | 71-3 v AFC WimbledonAFC Wimbledon 3-1 Oxford United | Sky Bet League One |
| 5 | Tue 28 Sep 2021 | 7 5-1 v Accrington StanleyOxford United 5-1 Accrington Stanley | Sky Bet League One |
| 6 | Sat 2 Oct 2021 | 72-1 v Sheffield WednesdaySheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 7 | Tue 5 Oct 2021 | 71-2 v StevenageOxford United 1-2 Stevenage | Papa John’s Trophy |
| 8 | Sat 23 Oct 2021 | 73-1 v Burton AlbionBurton Albion 1-3 Oxford United | Sky Bet League One |
| 9 | Sun 7 Nov 2021 | 72-2 v Bristol RoversOxford United 2-2 Bristol Rovers | Emirates FA Cup First Round |
| 10 | Sat 13 Nov 2021 | 70-0 v Ipswich TownIpswich Town 0-0 Oxford United | Sky Bet League One |
| 11 | Tue 16 Nov 2021 | 73-4 v Bristol RoversBristol Rovers 4-3 Oxford United | Emirates FA Cup First Round Replay |
| 12 | Tue 7 Dec 2021 | 72-1 v Doncaster RoversDoncaster Rovers 1-2 Oxford United | Sky Bet League One |
| 13 | Sat 11 Dec 2021 | 72-1 v Milton Keynes DonsMilton Keynes Dons 1-2 Oxford United | Sky Bet League One |
| 14 | Sat 18 Dec 2021 | 72-3 v Wigan AthleticOxford United 2-3 Wigan Athletic | Sky Bet League One |
| 15 | Wed 29 Dec 2021 | 73-0 v AFC WimbledonOxford United 3-0 AFC Wimbledon | Sky Bet League One |
| 16 | Sat 1 Jan 2022 | 71-1 v Cheltenham TownOxford United 1-1 Cheltenham Town | Sky Bet League One |
| 17 | Sat 8 Jan 2022 | 70-2 v Lincoln CityLincoln City 2-0 Oxford United | Sky Bet League One |
| 18 | Sat 15 Jan 2022 | 70-2 v Wycombe WanderersWycombe Wanderers 2-0 Oxford United | Sky Bet League One |
| 19 | Sat 29 Jan 2022 | 77-2 v GillinghamGillingham 2-7 Oxford United | Sky Bet League One |
| 20 | Tue 1 Feb 2022 | 71-1 v Wigan AthleticWigan Athletic 1-1 Oxford United | Sky Bet League One |
| 21 | Sat 5 Feb 2022 | 73-2 v PortsmouthOxford United 3-2 Portsmouth | Sky Bet League One |
| 22 | Tue 8 Feb 2022 | 7 0-2 v Accrington StanleyAccrington Stanley 2-0 Oxford United | Sky Bet League One |
| 23 | Sat 12 Feb 2022 | 72-3 v Bolton WanderersOxford United 2-3 Bolton Wanderers | Sky Bet League One |
| 24 | Sat 19 Feb 2022 | 74-0 v Charlton AthleticCharlton Athletic 0-4 Oxford United | Sky Bet League One |
| 25 | Tue 22 Feb 2022 | 71-0 v Crewe AlexandraCrewe Alexandra 0-1 Oxford United | Sky Bet League One |
| 26 | Sat 26 Feb 2022 | 74-2 v Cambridge UnitedOxford United 4-2 Cambridge United | Sky Bet League One |
| 27 | Tue 1 Mar 2022 | 72-3 v PortsmouthPortsmouth 3-2 Oxford United | Sky Bet League One |
| 28 | Sat 5 Mar 2022 | 74-1 v Burton AlbionOxford United 4-1 Burton Albion | Sky Bet League One |
| 29 | Sat 12 Mar 2022 | 72-1 v Shrewsbury TownShrewsbury Town 1-2 Oxford United | Sky Bet League One |
| 30 | Sat 19 Mar 2022 | 7 1-1 v Ipswich TownOxford United 1-1 Ipswich Town | Sky Bet League One |
| 31 | Sat 2 Apr 2022 | 70-1 v Plymouth ArgylePlymouth Argyle 1-0 Oxford United | Sky Bet League One |
| 32 | Tue 5 Apr 2022 | 7 1-2 v MorecambeMorecambe 2-1 Oxford United | Sky Bet League One |
| 33 | Fri 15 Apr 2022 | 73-2 v Fleetwood TownFleetwood Town 2-3 Oxford United | Sky Bet League One |
| 34 | Tue 19 Apr 2022 | 71-0 v Milton Keynes DonsOxford United 1-0 Milton Keynes Dons | Sky Bet League One |
| 35 | Sat 23 Apr 2022 | 7 1-2 v Rotherham UnitedRotherham United 2-1 Oxford United | Sky Bet League One |
| 36 | Sat 30 Apr 2022 | 71-1 v Doncaster RoversOxford United 1-1 Doncaster Rovers | Sky Bet League One |
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