| 1 | Sat 7 Aug 2021 | 111-1 v Cambridge UnitedCambridge United 1-1 Oxford United | Sky Bet League One |
| 2 | Wed 11 Aug 2021 | 111-1 v Burton AlbionBurton Albion 1-1 Oxford United | Carabao Cup First Round |
| 3 | Sat 14 Aug 2021 | 112-1 v Charlton AthleticOxford United 2-1 Charlton Athletic | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 111-2 v Bolton WanderersBolton Wanderers 2-1 Oxford United | Sky Bet League One |
| 5 | Tue 24 Aug 2021 | 110-2 v Queens Park RangersQueens Park Rangers 2-0 Oxford United | Carabao Cup Second Round |
| 6 | Sat 28 Aug 2021 | 113-1 v Lincoln CityOxford United 3-1 Lincoln City | Sky Bet League One |
| 7 | Sat 4 Sep 2021 | 111-3 v AFC WimbledonAFC Wimbledon 3-1 Oxford United | Sky Bet League One |
| 8 | Wed 29 Dec 2021 | 113-0 v AFC WimbledonOxford United 3-0 AFC Wimbledon | Sky Bet League One |
| 9 | Sat 1 Jan 2022 | 111-1 v Cheltenham TownOxford United 1-1 Cheltenham Town | Sky Bet League One |
| 10 | Sat 15 Jan 2022 | 110-2 v Wycombe WanderersWycombe Wanderers 2-0 Oxford United | Sky Bet League One |
| 11 | Sat 22 Jan 2022 | 113-2 v Sheffield WednesdayOxford United 3-2 Sheffield Wednesday | Sky Bet League One |
| 12 | Sat 29 Jan 2022 | 117-2 v GillinghamGillingham 2-7 Oxford United | Sky Bet League One |
| 13 | Tue 1 Feb 2022 | 111-1 v Wigan AthleticWigan Athletic 1-1 Oxford United | Sky Bet League One |
| 14 | Sat 5 Feb 2022 | 113-2 v PortsmouthOxford United 3-2 Portsmouth | Sky Bet League One |
| 15 | Tue 8 Feb 2022 | 110-2 v Accrington StanleyAccrington Stanley 2-0 Oxford United | Sky Bet League One |
| 16 | Sat 19 Feb 2022 | 114-0 v Charlton AthleticCharlton Athletic 0-4 Oxford United | Sky Bet League One |
| 17 | Sat 5 Mar 2022 | 114-1 v Burton AlbionOxford United 4-1 Burton Albion | Sky Bet League One |
| 18 | Sat 12 Mar 2022 | 112-1 v Shrewsbury TownShrewsbury Town 1-2 Oxford United | Sky Bet League One |
| 19 | Sat 19 Mar 2022 | 111-1 v Ipswich TownOxford United 1-1 Ipswich Town | Sky Bet League One |
| 20 | Sat 2 Apr 2022 | 110-1 v Plymouth ArgylePlymouth Argyle 1-0 Oxford United | Sky Bet League One |
| 21 | Tue 5 Apr 2022 | 111-2 v MorecambeMorecambe 2-1 Oxford United | Sky Bet League One |
| 22 | Sat 9 Apr 2022 | 111-2 v SunderlandOxford United 1-2 Sunderland | Sky Bet League One |
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